Mechanical chest compression with LUCAS device does not improve clinical outcome in out-of-hospital cardiac arrest patients

Liu, Mao; Shuai, Zhuang; Ai, Jiao; Tang, Kai Dun; Liu, Hui; Zheng, Jiankang; Gou, Junqi; Zhan, Lijun

doi:10.1097/md.0000000000017550

Cited by 39 publications

(38 citation statements)

References 32 publications

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“…These devices can be subdivided into three categories: point compression, load distribution compression, and full chest compression. Recent meta-analyses found no advantage of these devices over manual CPR compression, in the reduction of SCD rate, as well as long term mortality and complication of SCA [95,96]. LUCAS (Lund University Cardiopulmonary Assist) device is commonly used device for this purpose.…”

Section: Mechanical Chest Compressions (Mcc)mentioning

confidence: 99%

Sudden cardiac death: epidemiology, pathogenesis and management

Kumar

Avishay

Jones

et al. 2021

Rev. Cardiovasc. Med.

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Sudden cardiac death (SCD) is an unexpected sudden death due to a heart condition, that occurs within one hour of symptoms onset. SCD is a leading cause of death in western countries, and is responsible for the majority of deaths from cardiovascular disease. Moreover, SCD accounts for mortality in approximately half of all coronary heart disease patients. Nevertheless, the recent advancements made in screening, prevention, treatment, and management of the underlying causes has decreased this number. In this article, we sought to review established and new modes of screening patients at risk for SCD, treatment and prevention of SCD, and the role of new technologies in the field. Further, we delineate the current epidemiologic trends and pathogenesis. In particular, we describe the advancement in molecular autopsy and genetic testing, the role of target temperature management, extracorporeal membrane oxygenation (ECMO), cardiopulmonary resuscitation (CPR), and transvenous and subcutaneous implantable cardioverter devices (ICDs).

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Section: Mechanical Chest Compressions (Mcc)mentioning

confidence: 99%

Sudden cardiac death: epidemiology, pathogenesis and management

Kumar

Avishay

Jones

et al. 2021

Rev. Cardiovasc. Med.

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“…22 32 35 38 Further reviews do not distinguish between different chest compression techniques in their meta-analysis, as described earlier, 31 35 38 39 or only include one particular device. [40][41][42] Respectively, others focus only on in-hospital 43 or out-of-hospital 32 34 35 39 41 42 cardiac arrest.…”

Section: Open Accessmentioning

confidence: 99%

Automated mechanical cardiopulmonary resuscitation devices versus manual chest compressions in the treatment of cardiac arrest: protocol of a systematic review and meta-analysis comparing machine to human

et al. 2021

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IntroductionCardiac arrest is a leading cause of death in industrialised countries. Cardiopulmonary resuscitation (CPR) guidelines follow the principles of closed chest compression as described for the first time in 1960. Mechanical CPR devices are designed to improve chest compression quality, thus considering the improvement of resuscitation outcomes. This protocol outlines a systematic review and meta-analysis methodology to assess trials investigating the therapeutic effect of automated mechanical CPR devices at the rate of return of spontaneous circulation, neurological state and secondary endpoints (including short-term and long-term survival, injuries and surrogate parameters for CPR quality) in comparison with manual chest compressions in adults with cardiac arrest.Methods and analysisA sensitive search strategy will be employed in established bibliographic databases from inception until the date of search, followed by forward and backward reference searching. We will include randomised and quasi-randomised trials in qualitative analysis thus comparing mechanical to manual CPR. Studies reporting survival outcomes will be included in quantitative analysis. Two reviewers will assess independently publications using a predefined data collection form. Standardised tools will be used for data extraction, risks of bias and quality of evidence. If enough studies are identified for meta-analysis, the measures of association will be calculated by dint of bivariate random-effects models. Statistical heterogeneity will be evaluated by I2-statistics and explored through sensitivity analysis. By comprehensive subgroup analysis we intend to identify subpopulations who may benefit from mechanical or manual CPR techniques. The reporting follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.Ethics and disseminationNo ethical approval will be needed because data from previous studies will be retrieved and analysed. Most resuscitation studies are conducted under an emergency exception for informed consent. This publication contains data deriving from a dissertation project. We will disseminate the results through publication in a peer-reviewed journal and at scientific conferences.PROSPERO registration numberCRD42017051633.

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“…Findings were inconsistent and contradictory, leaving it uncertain if mechanical chest compressions during CPR may improve the outcome of patients suffering cardiac arrest. Also, several systematic reviews were unable to show a benefit for mechanical CPR [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Differences between manual CPR and corpuls cpr in regard to quality and outcome: study protocol of the comparing observational multi‐center prospective registry study on resuscitation (COMPRESS)

Seewald

Dopfer

Wnent

et al. 2021

Scand J Trauma Resusc Emerg Med

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Background The effect of mechanical CPR is diversely described in the literature. Different mechanical CPR devices are available. The corpuls cpr is a new generation of piston-driven devices and was launched in 2015. The COMPRESS-trial analyzes quality of chest compression and CPR-related injuries in cases of mechanical CPR by the corpuls cpr and manual CPR. Methods This article describes the design and study protocol of the COMPRESS-trial. This observational multi-center study includes all patients who suffered an out-of-hospital cardiac arrest (OHCA) where CPR is attempted in four German emergency medical systems (EMS) between January 2020 and December 2022. EMS treatment, in-hospital-treatment and outcome are anonymously reported to the German Resuscitation Registry (GRR). This information is linked with data from the defibrillator, the feedback system and the mechanical CPR device for a complete dataset. Primary endpoint is chest compression quality (complete release, compression rate, compression depth, chest compression fraction, CPR-related injuries). Secondary endpoint is survival (return of spontaneous circulation (ROSC), admission to hospital and survival to hospital discharge). The trial is sponsored by GS Elektromedizinische Geräte G. Stemple GmbH. Discussion This observational multi-center study will contribute to the evaluation of mechanical chest compression devices and to the efficacy and safety of the corpuls cpr. Trial registration DRKS, DRKS-ID DRKS00020819. Registered 31 July 2020.

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Mechanical chest compression with LUCAS device does not improve clinical outcome in out-of-hospital cardiac arrest patients

Cited by 39 publications

References 32 publications

Sudden cardiac death: epidemiology, pathogenesis and management

Sudden cardiac death: epidemiology, pathogenesis and management

Automated mechanical cardiopulmonary resuscitation devices versus manual chest compressions in the treatment of cardiac arrest: protocol of a systematic review and meta-analysis comparing machine to human

Differences between manual CPR and corpuls cpr in regard to quality and outcome: study protocol of the comparing observational multi‐center prospective registry study on resuscitation (COMPRESS)

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