Mechanical considerations for polymeric heart valve development: Biomechanics, materials, design and manufacturing

Li, Richard L.; Russ, Jonathan B.; Paschalides, Costas; Ferrari, Giovanni; Waisman, Haim; Kysar, Jeffrey W.; Kalfa, David

doi:10.1016/j.biomaterials.2019.119493

Cited by 76 publications

(56 citation statements)

References 213 publications

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“…Unlike the laborious hand sewing of biological tissue onto frames, PHVs can be manufactured using simple and automated fabrication techniques and can therefore be significantly less expensive and with better quality control. There has been a substantial work in recent years to develop a PHV 7,8 but none has yet reached the clinic, although recently the Foldax Tria surgical polymeric valve (https://foldax.com/) has undergone first-in-human implantation, with no data published yet. As well as valves for surgical implantation which is the topic of this paper, polymeric leaflets also show promise for trans-catheter valves.…”

Section: Introductionmentioning

confidence: 99%

Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis

et al. 2020

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“…The spongiosa layer provides lubrication during leaflet bending and pressurization and is composed of collagen fibers, hydrated PGs, and GAGs. Hydrated PGs and GAGs are also involved in oxygen and nutrient elements diffusion through the valve tissue, as well as growth factor sequestration and controlled release (Latif et al, 2005;Sacks et al, 2009;Li et al, 2019).…”

Section: Biomechanics Of Heart Valvesmentioning

confidence: 99%

Biomaterials in Valvular Heart Diseases

Taghizadeh

Ghavami

Derakhshankhah

et al. 2020

Front. Bioeng. Biotechnol.

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Valvular heart disease (VHD) occurs as the result of valvular malfunction, which can greatly reduce patient’s quality of life and if left untreated may lead to death. Different treatment regiments are available for management of this defect, which can be helpful in reducing the symptoms. The global commitment to reduce VHD-related mortality rates has enhanced the need for new therapeutic approaches. During the past decade, development of innovative pharmacological and surgical approaches have dramatically improved the quality of life for VHD patients, yet the search for low cost, more effective, and less invasive approaches is ongoing. The gold standard approach for VHD management is to replace or repair the injured valvular tissue with natural or synthetic biomaterials. Application of these biomaterials for cardiac valve regeneration and repair holds a great promise for treatment of this type of heart disease. The focus of the present review is the current use of different types of biomaterials in treatment of valvular heart diseases.

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“…The processing method of synthetic polymers is universal, which greatly facilitates the preparation of synthetic−/synthetic polymer composite scaffolds. By changing the composition or concentration of the polymer composite, the properties of the scaffold such as mechanical strength can be easily adjusted 71 . With understanding the physical, chemical, and physiological properties of different biodegradable synthetic polymers, we can design composite scaffolds with suitable degradation rates, mechanical properties, and cell adhesion that are compatible with natural valves by combining synthetic polymers with complementary properties.…”

Section: Synthetic Polymer‐based Composite Scaffoldmentioning

confidence: 99%

“…At present, more than 400 000 operations have been performed in more than 70 countries 88 . The main advantages of this method are features of less trauma, no extracorporeal circulation, and better recovery and hemodynamic performance than conventional valve implantation 7,89,90 . However, TAVI still has serious complications such as annulus rupture, cardiac tamponade, valve embolization, coronary obstruction, or other complications requiring urgent surgical intervention 91 .…”

Section: Minimally Invasive Implantation Of Tehvmentioning

confidence: 99%

Biodegradable synthetic polymeric composite scaffold‐based tissue engineered heart valve with minimally invasive transcatheter implantation

Long

et al. 2020

Polymers for Advanced Techs

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Prosthetic heart valve replacement is the main treatment for valvular heart disease, but the existing artificial valves (mechanical or biological valve) have inherent disadvantages. Patients with mechanical valves require lifelong anticoagulation because of the high risk of thromboembolism, while the durability of biological valve is poor, which easily leads to calcification or lobular degeneration. Besides, they all lack the abilities of self‐repair and growth which are very important for adolescent patients with valvular heart disease. To overcome these shortcomings, the researchers developed tissue engineered heart valves (TEHV) with self‐repairing and remodeling capabilities, low immunogenicity, and great durability. The preparation of three‐dimensional porous scaffolds is the key step in the success of TEHV. Because of their easy processing, active chemical properties, great mechanical properties and controllable degradation rate, synthetic biodegradable polymers are widely used in the preparation of TEHV scaffolds. This review summarizes the types, properties and process techniques of biodegradable synthetic polymers, such as polycaprolactone, polyglycolic acid, polylactic acid, and polyhydroxyalkanoates currently used to prepare the TEHV scaffolds. This review also focuses on the composite methods and performance of synthetic polymer‐based composite scaffolds. The prospects and challenges of the clinical application for minimally invasive implantation of TEHV are also discussed.

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Mechanical considerations for polymeric heart valve development: Biomechanics, materials, design and manufacturing

Cited by 76 publications

References 213 publications

Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis

Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis

Biomaterials in Valvular Heart Diseases

Biodegradable synthetic polymeric composite scaffold‐based tissue engineered heart valve with minimally invasive transcatheter implantation

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