Mechanical cues in orofacial tissue engineering and regenerative medicine

Brouwer, Katrien M.; Lundvig, Ditte M. S.; Middelkoop, Esther; Wagener, Frank A. D. T. G.; Hoff, Johannes W. Von den

doi:10.1111/wrr.12283

Cited by 31 publications

(23 citation statements)

References 133 publications

(260 reference statements)

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“…Since a cleft palate is a large critical size defect that is influenced by strong masticatory forces [40], a stable and permanent bone substitute is essential that first enables a direct contact to mature bone and second promotes the formation of new bone produced naturally in the patient [18]. That is why the tissue engineering approach is very promising, even if the present study has shown a negative clinical result.…”

Section: Discussionmentioning

confidence: 85%

Assessing agreement between preclinical magnetic resonance imaging and histology: An evaluation of their image qualities and quantitative results

et al. 2017

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One consequence of demographic change is the increasing demand for biocompatible materials for use in implants and prostheses. This is accompanied by a growing number of experimental animals because the interactions between new biomaterials and its host tissue have to be investigated. To evaluate novel materials and engineered tissues the use of non-destructive imaging modalities have been identified as a strategic priority. This provides the opportunity for studying interactions repeatedly with individual animals, along with the advantages of reduced biological variability and decreased number of laboratory animals. However, histological techniques are still the golden standard in preclinical biomaterial research. The present article demonstrates a detailed method comparison between histology and magnetic resonance imaging. This includes the presentation of their image qualities as well as the detailed statistical analysis for assessing agreement between quantitative measures. Exemplarily, the bony ingrowth of tissue engineered bone substitutes for treatment of a cleft-like maxillary bone defect has been evaluated. By using a graphical concordance analysis the mean difference between MRI results and histomorphometrical measures has been examined. The analysis revealed a slightly but significant bias in the case of the bone volume and a clearly significant deviation for the remaining defect width But the study although showed a considerable effect of the analyzed section position to the quantitative result. It could be proven, that the bias of the data sets was less originated due to the imaging modalities, but mainly on the evaluation of different slice positions. The article demonstrated that method comparisons not always need the use of an independent animal study, additionally.

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Section: Discussionmentioning

confidence: 85%

Assessing agreement between preclinical magnetic resonance imaging and histology: An evaluation of their image qualities and quantitative results

et al. 2017

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“…An accumulation of collagen type I and III fibers and other ECM proteins after injury results in a disorganized fiber structure and hypertrophic scar formation . Wound tension or mechanical stress is another causative factor for scar formation . The skin of the human face is maximally extensible perpendicular to relaxed skin tension lines, implying that tension is minimized when surgical incisions are created along these lines …”

Section: Cleft Surgery Can Results In Fibrosis and Scar Formationmentioning

confidence: 99%

“…65,66 Wound tension or mechanical stress is another causative factor for scar formation. 67,68 The skin of the human face is maximally extensible perpendicular to relaxed skin tension lines, implying that tension is minimized when surgical incisions are created along these lines. 67 Prolonged inflammation and oxidative stress blocks the remodeling phase and promotes excessive fibrosis and scarring.…”

Section: Cleft Surgery Can Results In Fibrosis and Scar Formationmentioning

confidence: 99%

“…The sum of pro‐ and anti‐inflammatory and fibrotic factors, the shape of scaffolds, stiffness of the matrix, nanotopography and the presence of biofunctional groups as RGD‐sequences discriminates between scarring and regeration of tissue . Mechanical cues may be applied in tissue engineering by adjusting the type, stiffness and architecture of the scaffolds facilitating the differentiation of cord blood stem cells into either skin or muscle tissue …”

Section: Clinical Challenges For Scaffold‐based Cord Blood Stem Cellsmentioning

confidence: 99%

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Tissue engineering strategies combining molecular targets against inflammation and fibrosis, and umbilical cord blood stem cells to improve hampered muscle and skin regeneration following cleft repair

Schreurs

Suttorp

Mutsaers

et al. 2019

Medicinal Research Reviews

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Cleft lip with or without cleft palate is a congenital deformity that occurs in about 1 of 700 newborns, affecting the dentition, bone, skin, muscles and mucosa in the orofacial region. A cleft can give rise to problems with maxillofacial growth, dental development, speech, and eating, and can also cause hearing impairment. Surgical repair of the lip may lead to impaired regeneration of muscle and skin, fibrosis, and scar formation. This may result in hampered facial growth and dental development affecting oral function and lip and nose esthetics. Therefore, secondary surgery to correct the scar is often indicated. We will discuss the molecular and cellular pathways involved in facial and lip myogenesis, muscle anatomy in the normal and cleft lip, and complications following surgery. The aim of this review is to outline a novel molecular and cellular strategy to improve musculature and skin regeneration and to reduce scar formation following cleft repair. Orofacial clefting can be diagnosed in the fetus through prenatal ultrasound screening and allows planning for the harvesting of umbilical cord blood stem cells upon birth. Tissue engineering techniques using these cord blood stem cells and molecular targeting of inflammation and fibrosis during surgery may promote tissue regeneration. We expect that this novel strategy improves both muscle and skin regeneration, resulting in better function and esthetics after cleft repair.

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“…Surgery and other types of traumatic injury not only cause inflammatory injury, fibrosis, and scar formation (Brouwer et al, 2015), but are associated with the release of free heme (Wagener et al, 2003a). Heme is the prosthetic group of a number of physiologically important hemoproteins (e.g., hemoglobin, cytochromes or cyclooxygenase).…”

mentioning

confidence: 99%