This experimental study compares the mean and turbulence characteristics of turbulent channel flows with polymer injection at the wall and at the centerline to assess the impact of the injection location on drag reduction. It also contrasts the drag reduction performance of a hydrolyzed polymer versus a non-ionic polymer under the same conditions. Wall injection of non-ionic and hydrolized polymers resulted in 23% and 9% larger drag reduction than corresponding centerline injection, respectively. In all cases, the polymer was structured and the presence of macromolecular polymer structures, even when concentrated mostly away from the wall, seemed to be able to affect the turbulence structure in the flow.