Mechanical Evaluation of Poly-ε-Caprolactone and Biosilicate® Composites

Weber, Aline F.; Monteiro, R. S.; Malmonge, Sônia Maria; Souza, Marina Trevelin; Petil, O.; Daguano, Juliana Kelmy Macário Barboza

doi:10.1007/978-981-13-2119-1_14

Cited by 1 publication

(1 citation statement)

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“…One of the key challenges in regenerating different tissues, especially bone, is manufacturing scaffolds with appropriate mechanical properties [41]. The compressive strength of human cancellous bone is about 4-50 MPa, and tensile values range from 5 to 40 MPa, according to various studies [42][43][44]. This study's compressive test results indicated PCL/CZS scaffolds had mechanical properties similar to those of bone; therefore, they can be considered for bone regeneration applications.…”

Section: Mechanical Propertiesmentioning

confidence: 69%

3D-Printed Polycaprolactone-Based Containing Calcium Zirconium Silicate: Bioactive Scaffold for Accelerating Bone Regeneration

Emadi,

Baghani,

Masoudi Rad

et al. 2024

Polymers

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There is an essential clinical need to develop rapid process scaffolds to repair bone defects. The current research presented the development of calcium zirconium silicate/polycaprolactone for bone tissue engineering utilising melt extrusion-based 3D printing. Calcium zirconium silicate (CZS) nanoparticles were added to polycaprolactone (PCL) porous scaffolds to enhance their biological and mechanical properties, while the resulting properties were studied extensively. No significant difference was found in the melting point of the samples, while the crystallisation temperature points of the samples containing bioceramic increased from 36.1 to 40.2 °C. Thermal degradation commenced around 350 °C for all materials. According to our results, increasing the CZS content from 0 to 40 wt.% (PC40) in porous scaffolds (porosity about 55–62%) improved the compressive strength from 2.8 to 10.9 MPa. Furthermore, apatite formation ability in SBF solution increased significantly by enhancing the CZS percentage. According to MTT test results, the viability of MG63 cells improved remarkably (~29%) in PC40 compared to pure PCL. These findings suggest that a 3D-printed PCL/CZS composite scaffold can be fabricated successfully and shows great potential as an implantable material for bone tissue engineering applications.

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