“…Over the last decade or so, coupled mechanical forces have been used to drive a range of targeted covalent responses in isolated polymers and in bulk polymeric materials (covalent polymer mechanochemistry). 1,2 Mechanochemical strategies continue to evolve, including in very recent years their use in biasing and probing reaction pathways, 3,4 the release of small molecules and protons, 5,6 stress reporting, [7][8][9][10][11] stress strengthening, 12,13 degradable polymers, 14,15 and fundamental studies of polymer behavior under load. 16 In organic reactions, mechanochemical coupling has been investigated in simple bond dissociation reactions [17][18][19] and in a wide variety of reaction classes with respect to regiochemistry, [20][21][22][23][24] orbital symmetry, 20,[25][26][27] stereochemistry, 28,29 supramolecular architecture, [30][31][32] dynamic effects, 33,34 and the alignment and/or loading of scissile bonds with applied tension.…”