Mechanical improvement of chitosan–gelatin scaffolds reinforced by β-tricalcium phosphate bioceramic

Putri, Tansza Setiana; Ratnasari, Ayu; Sofiyaningsih, Naili; Nizar, Muhammad Syaifun; Yuliati, Anita; Shariff, Khairul Anuar

doi:10.1016/j.ceramint.2021.12.367

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…It was found that the density of hydrophilic groups in the structure affected the degradation of the scaffold. Putri et al 18 revealed that the porosity of the ChG scaffold is higher than the scaffold with the addition of βTCP. Higher porosity means less density; thus, ChG has higher degradation.…”

Section: Discussionmentioning

confidence: 99%

“…Putri et al 18 found that the scaffold containing βTCP has lower porosity compared to the ChG scaffold. This also corresponds to the result of this study.…”

Section: Discussionmentioning

confidence: 99%

“…16,17 Limestone has a main component of calcium carbonate, which makes it a potential source of calcium in fabricating βTCP. [17][18][19] Putri et al, [18][19][20] successfully fabricated a composite scaffold from ChG with the addition of βTCP derived from limestone. However, the degradation of the scaffold has not yet been evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Degradation of chitosan–gelatin and chitosan–gelatin–β-tricalcium phosphate scaffolds

Putri,

Pratiwi,

Margaretta

et al. 2024

Dent. J.

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Background: Fabrication of the composite scaffold was carried out by combining chitosan, gelatin, and β-tricalcium phosphate (βTCP) derived from limestone. The extraction of βTCP was based on the abundance of limestone containing calcium carbonate, which can be a source of βTCP synthesis. Purpose: This study evaluates the degradation of the combination of chitosan–gelatin (ChG) and chitosan–gelatin–βTCP (ChG-βTCP) composite scaffolds. Methods: The freeze-drying method was used to obtain the composite scaffold, which was a mixture of chitosan, gelatin, and βTCP. Degradation was measured by immersing the samples in a simulated body fluid solution at 37°C for 3, 7, 14, and 21 days. For statistical analysis, one-way analysis of variance (ANOVA) and post hoc Fisher’s least significant difference were performed. Results: The ChG scaffold shows better degradability than the ChG-βTCP scaffold. The ChG scaffold shows higher weight degradation than the ChG-βTCP scaffold up to 21 days. Conclusion: In conclusion, the scaffold containing βTCP has lower degradation than the ChG scaffold.

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Section: Discussionmentioning

confidence: 99%

“…Putri et al 18 found that the scaffold containing βTCP has lower porosity compared to the ChG scaffold. This also corresponds to the result of this study.…”

Section: Discussionmentioning

confidence: 99%

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Degradation of chitosan–gelatin and chitosan–gelatin–β-tricalcium phosphate scaffolds

Putri,

Pratiwi,

Margaretta

et al. 2024

Dent. J.

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“…Better electrospinnability was achieved between zein and gelatin, which resulted in improved mechanical properties, hydrophilicity, and cell adhesiveness of the zein membranes [ 121 ]. In bone tissue engineering, zein-based scaffolds have a number of benefits, including the development of osteogenic properties and good mucoadhesive properties for drug delivery applications [ 122 , 123 , 124 ].…”

Section: Proteins Based Scaffoldsmentioning

confidence: 99%

Scaffold Using Chitosan, Agarose, Cellulose, Dextran and Protein for Tissue Engineering—A Review

et al. 2023

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Biological macromolecules like polysaccharides/proteins/glycoproteins have been widely used in the field of tissue engineering due to their ability to mimic the extracellular matrix of tissue. In addition to this, these macromolecules are found to have higher biocompatibility and no/lesser toxicity when compared to synthetic polymers. In recent years, scaffolds made up of proteins, polysaccharides, or glycoproteins have been highly used due to their tensile strength, biodegradability, and flexibility. This review is about the fabrication methods and applications of scaffolds made using various biological macromolecules, including polysaccharides like chitosan, agarose, cellulose, and dextran and proteins like soy proteins, zein proteins, etc. Biopolymer-based nanocomposite production and its application and limitations are also discussed in this review. This review also emphasizes the importance of using natural polymers rather than synthetic ones for developing scaffolds, as natural polymers have unique properties, like high biocompatibility, biodegradability, accessibility, stability, absence of toxicity, and low cost.

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Copper–strontium hydroxyapatite/chitosan/polyvinyl alcohol/gelatin electrospun composite and its biological studies for orthopedic applications

2023

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Mechanical improvement of chitosan–gelatin scaffolds reinforced by β-tricalcium phosphate bioceramic

Cited by 7 publications

References 22 publications

Degradation of chitosan–gelatin and chitosan–gelatin–β-tricalcium phosphate scaffolds

Degradation of chitosan–gelatin and chitosan–gelatin–β-tricalcium phosphate scaffolds

Scaffold Using Chitosan, Agarose, Cellulose, Dextran and Protein for Tissue Engineering—A Review

Copper–strontium hydroxyapatite/chitosan/polyvinyl alcohol/gelatin electrospun composite and its biological studies for orthopedic applications

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