Mechanical Induction of Osteogenesis

Alveolar distraction osteogenesis: a systematic review

“…Various complications described by COMPERE 14 impeded its further use and resulted in only sporadic application in the craniofacial region 43,62 . The series of experimental and clinical studies 31,32 performed in the 1950s in Siberia by the Russian physician Gavriel Awramowitch Ilizarov greatly advanced this technique in particular and orthopaedic therapy in general 4 . ILIZAROV explored the possibility of monofocal, bifocal and trifocal callotasis in transport osteogenesis and established two basic principles of DO: (1) the law of tension-stress and (2) the influence of mechanical load and vascular supply.…”

Forces measured during femoral lengthening in children

“…This rises to 75% after 28 days, and then decreases to 40% at the end of lengthening. A rise to almost normal occurs during the neutral fixation period (Aronson, 1988). The strength of the femur on axial loading has been linearly correlated to the degree of calcification by Alho et al (1988).…”

Assessment of the distraction regenerate using three-dimensional quantitative computer tomography

“…The mean density of the total regenerate was calculated from the mean densities of the thirty 3D-ROIs (ROIs 6-93). Furthermore, the total distraction regenerate was divided from proximal to distal into five DO regions, each consisting of six 3D-ROI and mean densities were calculated for each DO region (1)(2)(3)(4)(5). A supplementary standardized 3D-ROI was drawn 5 mm posterior of the proximal margin of the distraction gap in order to calculate the mean density of the host cranial bone.…”

“…However, only a few clinical 18,19,24,25,27,29,39,58 and experimental 12,21,26,34,[43][44][45][50][51][52] imaging studies have been published that attempt to quantify the process of bone regeneration by DO in the craniofacial skeleton. At the contrary, the orthopaedic DO literature provides a variety of objective imaging techniques 23 to quantify the mineralization process in the regenerate, such as photo densitometry of standard X-rays 3,15,42 , digital radiography 28 , quantitative computer tomography (QCT) 4,22,36,41,53,54 , dual-photon absorptiometry 35,55 and dual-energy X-ray absorptiometry (DEXA) 11,[14][15][16][17]20,31,36,37,56 , ultrasonography 10,15,30,38,57 , quantitative technetium scintigraphy 5,33,…”