Mechanical instability of normal and aneurysmal arteries

Lee, Avione Y.; Sanyal, Arnav; Xiao, Yonggui; Shadfan, Ramsey; Han, Hugang

doi:10.1016/j.jbiomech.2014.10.010

Cited by 20 publications

(35 citation statements)

References 46 publications

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“…The changes in imperfection has negligible effect on the predicted critical buckling behavior as demonstrated in our pilot studies and previous work (Lee et al 2014; Fatemifar and Han 2016). The model was meshed using solid hexahedral elements and analyzed (after meshing sensitivity analysis) using the commercial software ABAQUS (Lee et al 2014; Fatemifar and Han 2016). One end of the vein was restrained in all degrees of freedom except the radial translation that allow the vein to expand freely under lumen blood pressure.…”

Section: Methodssupporting

confidence: 81%

“…A cylindrical model of each vein was constructed using Solidworks with the experimentally measured no-load configuration dimensions: inner radius (Ri), outer radius (Re), and segment length (L). A static general analysis approach (Northcutt et al 2009; Lee et al 2014) was used with a small imperfection (1-3% reduction in diameter in middle of the vessel length) was added to the central region of the vein to facilitate twist buckling and kink formation. The changes in imperfection has negligible effect on the predicted critical buckling behavior as demonstrated in our pilot studies and previous work (Lee et al 2014; Fatemifar and Han 2016).…”

Section: Methodsmentioning

confidence: 99%

“…A static general analysis approach (Northcutt et al 2009; Lee et al 2014) was used with a small imperfection (1-3% reduction in diameter in middle of the vessel length) was added to the central region of the vein to facilitate twist buckling and kink formation. The changes in imperfection has negligible effect on the predicted critical buckling behavior as demonstrated in our pilot studies and previous work (Lee et al 2014; Fatemifar and Han 2016). The model was meshed using solid hexahedral elements and analyzed (after meshing sensitivity analysis) using the commercial software ABAQUS (Lee et al 2014; Fatemifar and Han 2016).…”

Section: Methodsmentioning

confidence: 99%

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Twist buckling of veins under torsional loading

Garcia

Sanyal

Fatemifar

et al. 2017

Journal of Biomechanics

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Veins are often subjected to torsion and twisted veins can hinder and disrupt normal blood flow but their mechanical behavior under torsion is poorly understood. The objective of this study was to investigate the twist deformation and buckling behavior of veins under torsion. Twist buckling tests was performed on porcine internal jugular veins (IJVs) and human great saphenous veins (GSVs) at various axial stretch ratio and lumen pressure conditions to determine their critical buckling torques and critical buckling twist angles. The mechanical behavior under torsion was characterized using a two-fiber strain energy density function and the buckling behavior was then simulated using finite element analysis. Our results demonstrated that twist buckling occurred in all veins under excessive torque characterized by a sudden kink formation. The critical buckling torque increased significantly with increasing lumen pressure for both porcine IJV and human GSV. But lumen pressure and axial stretch had little effect on the critical twist angle. The human GSVs are stiffer than the porcine IJVs. Finite element simulations captured the buckling behavior for individual veins under simultaneous extension, inflation, and torsion with strong correlation between predicted critical buckling torques and experimental data (R2=0.96). We conclude that veins can buckle under torsion loading and the lumen pressure significantly affects the critical buckling torque. These results improve our understanding of vein twist behavior and help identify key factors associated in the formation of twisted veins.

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Section: Methodssupporting

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Twist buckling of veins under torsional loading

Garcia

Sanyal

Fatemifar

et al. 2017

Journal of Biomechanics

Self Cite

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“…Since arteries are under considerable longitudinal strain in vivo, axial displacements in longitudinal direction were applied at both ends to create various axial stretch ratios in the models. Then, an external pressure was applied to generate buckling and keep increasing to simulate the buckling behavior of all models at a series of designated stretch ratios [25].…”

Section: Finite-element Analysis Of Buckling and Postbucklingmentioning

confidence: 99%

Effect of Axial Stretch on Lumen Collapse of Arteries

Fatemifar

Han

2016

Journal of Biomechanical Engineering

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The stability of the arteries under in vivo pressure and axial tension loads is essential to normal arterial function, and lumen collapse due to buckling can hinder the blood flow. The objective of this study was to develop the lumen buckling equation for nonlinear anisotropic thick-walled arteries to determine the effect of axial tension. The theoretical equation was developed using exponential Fung strain function, and the effects of axial tension and residual stress on the critical buckling pressure were illustrated for porcine coronary arteries. The buckling behavior was also simulated using finite-element analysis. Our results demonstrated that lumen collapse of arteries could occur when the transmural pressure is negative and exceeded a critical value. This value depends upon the axial stretch ratio and material properties of the arterial wall. Axial tensions show a biphasic effect on the critical buckling pressure. The lumen aspect ratio of arteries increases nonlinearly with increasing external pressure beyond the critical value as the lumen collapses. These results enhance our understanding of artery lumen collapse behavior.

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“…The cause of the decrease in tortuosity was postulated to be secondary increases in height (resulting in ‘stretching’ of the artery), medical therapy, or changes in vascular signaling with age. Some investigators have proposed that the presence of an aneurysm may be actually reduce a “critical buckling pressure” of the artery, and that buckling may be a mechanism of tortuosity in genetically mediated aortopathy 18 . While there are multiple proposed mechanisms, further work is needed to better delineate etiologies and timing of tortuosity.…”

Section: Text Of Reviewmentioning

confidence: 99%

Arterial tortuosity in genetic arteriopathies

Morris

2015

Current Opinion in Cardiology

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Purpose of Review Arterial tortuosity is emerging as a common feature in genetically mediated thoracic aortic disease that may be prognostic. This review will summarize recent literature on arterial tortuosity in the setting of genetic arteriopathies. Recent Findings While arterial tortuosity has been primarily described in Loeys-Dietz syndrome due to TGFBR1 and TGFBR2 mutations and in arterial tortuosity syndrome due to SLC210A mutations, recent studies that use quantitative measures of tortuosity suggest that tortuosity is present in many other genetic conditions associated with aortic dilation and dissection. The mechanisms of the development of tortuosity in these disorders are not fully understood, but are founded in the concept that there is abnormal, pathologic arterial lengthening in a fixed space, resulting in more tortuous vessels. Further studies suggest that patients with increased arterial tortuosity are at increased risk of adverse cardiovascular events, including aortic surgery, aortic dissection, and death. Summary Arterial tortuosity in commonly present in genetically mediated aortic disease. Given the suboptimal performance of aortic dimension alone in predicting aortic dissection, quantification of tortuosity may augment the current algorithms for determining risk in patients with aortic disease.

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Mechanical instability of normal and aneurysmal arteries

Cited by 20 publications

References 46 publications

Twist buckling of veins under torsional loading

Twist buckling of veins under torsional loading

Effect of Axial Stretch on Lumen Collapse of Arteries

Arterial tortuosity in genetic arteriopathies

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