Mechanical integrity of magnesium alloys for biomedical applications

Choudhary, Lokesh; Raman, R.K. Singh

doi:10.1016/b978-1-78242-077-4.00005-x

Cited by 2 publications

(1 citation statement)

References 90 publications

(100 reference statements)

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“…screws and plates) fabricated with these alloys are used for temporary fixation of fractured bone; however, a second surgery is required to remove the temporary implants [1]. Localized cell death, excessive fibrotic tissue formation, and longlasting inflammation can also result from the release of toxic metals from metallic biomaterials, such as Ni, Cr, V, and Co [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Insight into synergetic effects of serum albumin and glucose on the biodegradation behavior of WE43 alloy in simulated body fluid

et al. 2022

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The biodegradation rate of Mg alloy medical devices, such as screws and plates for temporary bone fracture fixation or coronary angioplasty stents, is an increasingly important area of study. In vitro models of the corrosion behavior of these devices use revised simulated body fluid (m-SBF) based on a healthy individual’s blood chemistry. Therefore, model outputs have limited application to patients with altered blood plasma glucose or protein concentrations. This work studies the biodegradation behavior of the Mg alloy, WE43, in m-SBF modified with varying concentrations of glucose and bovine serum albumin (BSA) to 1) mimic a range of disease states and 2) determine the contributions of each biomolecule to corrosion. Measurements include the Mg ion release rate, electrolyte pH, the extent of hydrogen evolution (as a proxy for corrosion rate), surface morphology, and corrosion product composition and effects. BSA (0.1 g L–1) suppresses the rate of hydrogen evolution (about 30%) after 24 h and—to a lesser degree—Mg2+ release in both the presence and absence of glucose. This effect gets more pronounced with time, possibly due to BSA adsorption on the Mg surface. Electrochemical studies confirm that adding glucose (2 g L–1) to the solution containing BSA (0.1 g L–1) caused a decrease in corrosion resistance (by around 40%), and concomitant increase in the hydrogen evolution rate (from 10.32-11.04 mg cm–2 d–1) to levels far beyond the tolerance limits of live tissues.

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Section: Introductionmentioning

confidence: 99%

Insight into synergetic effects of serum albumin and glucose on the biodegradation behavior of WE43 alloy in simulated body fluid

et al. 2022

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Effect of solution treatment on stress corrosion cracking behavior of an as-forged Mg-Zn-Y-Zr alloy

Wang

et al. 2016

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Effect of solid solution treatment (T4) on stress corrosion cracking (SCC) behavior of an as-forged Mg-6.7%Zn-1.3%Y-0.6%Zr (in wt.%) alloy has been investigated using slow strain rate tensile (SSRT) testing in 3.5 wt.% NaCl solution. The results demonstrated that the SCC susceptibility index (ISCC) of as-forged samples was 0.95 and its elongation-to-failure (εf) was only 1.1%. After T4 treatment, the SCC resistance was remarkably improved. The ISCC and εf values of T4 samples were 0.86 and 3.4%, respectively. Fractography and surface observation indicated that the stress corrosion cracking mode for as-forged samples was dominated by transgranular and partially intergranular morphology, whereas the cracking mode for T4 samples was transgranular. In both cases, the main cracking mechanism was associated with hydrogen embrittlement (HE). Through alleviating the corrosion attack of Mg matrix, the influence of HE on the SCC resistance of T4 samples can be greatly suppressed.

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Mechanical integrity of magnesium alloys for biomedical applications

Cited by 2 publications

References 90 publications

Insight into synergetic effects of serum albumin and glucose on the biodegradation behavior of WE43 alloy in simulated body fluid

Insight into synergetic effects of serum albumin and glucose on the biodegradation behavior of WE43 alloy in simulated body fluid

Effect of solution treatment on stress corrosion cracking behavior of an as-forged Mg-Zn-Y-Zr alloy

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