Mechanical Load and BMP Signaling During Tendon Repair: A Role for Follistatin?

Eliasson, Pernilla; Fahlgren, Anna; Aspenberg, Per

doi:10.1007/s11999-008-0253-0

Cited by 52 publications

(38 citation statements)

References 19 publications

(38 reference statements)

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“…Future studies in a more homogenous population (controlled for variables such as surgical/non-surgical management, rehabilitation, and time from injury) may help in identifying differences between sides with regard to shear modulus. Increased tendon cross sectional area following Achilles tendon rupture has been reported previously in animal and human studies 10,11,29,30 . Furthermore, level of activity and surgical versus non-surgical intervention has been found to affect tendon cross sectional area 11 .…”

Section: Discussionsupporting

confidence: 64%

Side-to-side differences in Achilles tendon geometry and mechanical properties following achilles tendon rupture

Zellers

Cortés

Corrigan

et al. 2017

MLTJ

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SummaryBackground: Recovery of tendon structure has been suggested to play a role in clinical success following Achilles tendon rupture. The purpose of this study was to identify side-to-side differences in tendon geometry and mechanical properties following Achilles tendon rupture and investigate the relationship of tendon structure with clinical outcomes. Methods: Participants within 1 year post complete rupture were included. Tendon geometry and mechanical properties were quantified using B-mode ultrasound imaging and continuous shear wave elastography (cSWE). Clinical outcomes included the heel-rise test. Participant self-reported function was measured using the Achilles tendon Total Rupture Score, Foot and Ankle Outcome Score -quality of life subscale, and the Physical Activity

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Section: Discussionsupporting

confidence: 64%

Side-to-side differences in Achilles tendon geometry and mechanical properties following achilles tendon rupture

Zellers

Cortés

Corrigan

et al. 2017

MLTJ

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“…An attractive model is one in which Scx (in concert with TGFβ signaling) shifts the fate of MSCs towards TPCs and initiates tendon ECM production, whereas factors expressed later in development, such as Mkx and Egr1, supplement the role of Scx by inducing the expression of ECM proteins as well as by repressing myogenic and skeletogenic fates. Furthermore, signaling mediated by mechanical forces upregulates expression of Scx, Mkx and Smad3, stimulating more ECM production, thereby providing positive feedback for fine-tuning tendon strength, as we discuss further below (Eliasson et al, 2008;Maeda et al, 2011).…”

Section: /Egr2mentioning

confidence: 99%

Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix

2015

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Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with muscles via the ECM to establish connectivity and strengthen attachments under tension. Similarly, ECM-dependent interactions between tenocytes and cartilage/bone ensure that tendon-bone attachments form with the appropriate strength for the force required. Recent studies have also established a close lineal relationship between tenocytes and skeletal progenitors, highlighting the fact that defects in signals modulated by the ECM can alter the balance between these fates, as occurs in calcifying tendinopathies associated with aging. The dynamic finetuning of tendon ECM composition and assembly thus gives rise to the remarkable characteristics of this unique tissue type. Here, we provide an overview of the functions of the ECM in tendon formation and maturation that attempts to integrate findings from developmental genetics with those of matrix biology.

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“…Extraction of total RNA was performed using the TRIspin method described in detail in [Eliasson et al, 2008]. Frozen bone specimens were placed one by one in a liquid-nitrogen-cooled vessel and pulverized using a Retsch Mixer Mill MM 200 (Retsch GmbH, Germany).…”

Section: Gene Expression Analysesmentioning

confidence: 99%

Fluid pressure induces osteoclast differentiation comparably to titanium particles but through a molecular pathway only partly involving TNFα

Nilsson¹,

Norgård²,

Andersson³

et al. 2012

J of Cellular Biochemistry

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In contrast to the well-understood inflammatory pathway driven by TNFα, by which implant-derived particles induce bone resorption, little is known about the process in which loosening is generated as a result of force-induced mechanical stimulus at the bone-implant interface. Specifically, there is no knowledge as to what cells or signaling pathways couple mechanical stimuli to bone resorption in context of loosening. We hypothesized that different stimuli, i.e., fluid flow versus wear particles, act through different cytokine networks for activation and localization of osteoclasts. By using an animal model in which osteoclasts and bone resorption were induced by fluid pressure or particles, we were able to detect distinct differences in osteoclast localization and inflammatory gene expression between fluid pressure and titanium particles. Fluid pressure recruits and activates osteoclasts with bone marrow contact away from the fluid pressure exposure zone, whereas titanium particles recruit and activate osteoclasts in areas in direct contact to particles. Fluid pressure induced weaker expression of the selected inflammatory related genes, although the eventual degree of osteoclast induction was similar in both models. Using TNFαRa (4 mg/kg) (Enbrel) and dexamethasone (2 mg/kg) as specific and more general suppressors of inflammation we showed that the TNFαRa failed to generate statistically impaired osteoclast generation while dexamethasone was much more potent. These results demonstrate that fluid pressure induces osteoclasts at a different localization than titanium particles by a molecular pathway less associated with TNFα and the innate system, which open up for other pathways controlling pressure induced osteoclastogenesis.

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Mechanical Load and BMP Signaling During Tendon Repair: A Role for Follistatin?

Cited by 52 publications

References 19 publications

Side-to-side differences in Achilles tendon geometry and mechanical properties following achilles tendon rupture

Side-to-side differences in Achilles tendon geometry and mechanical properties following achilles tendon rupture

Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix

Fluid pressure induces osteoclast differentiation comparably to titanium particles but through a molecular pathway only partly involving TNFα

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