Mechanical, material, and biological study of a PCL/bioactive glass bone scaffold: Importance of viscoelasticity

Shahin‐Shamsabadi, Alireza; Hashemi, Ata; Tahriri, Mohammadreza; Bastami, Farshid; Salehi, Majid; Abbas, Fatemeh Mashhadi

doi:10.1016/j.msec.2018.04.080

Cited by 61 publications

(45 citation statements)

References 62 publications

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“…The 2 time-scale standard linear solid model has recently been applied to the analysis of the rheological behaviour of other materials, such as polycaprolactone bioactive glass tested under compression 155 and single collagen fibrils from the extracellular matrix under tensile testing. 10 Given that they present the same qualitative behaviour as the epithelial monolayers (power-law followed by exponential behaviour until a final steady-state value is reached), we have successfully applied the fractional model recently developed by Bonfanti et al 66 to data from these other materials.…”

Section: 224mentioning

confidence: 99%

Fractional viscoelastic models for power-law materials

et al. 2020

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Section: 224mentioning

confidence: 99%

Fractional viscoelastic models for power-law materials

et al. 2020

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“…To produce the composite electrospun mats, 45S5, BGMS10, and BGMS_2Zn were homogenously dispersed (5 wt% respect to PCL) in the polymer solution and mixed for 10 min and subsequently immersed in ultrasonic bath for 1 min before electrospinning. The amount of bioactive glass was chosen at 5 wt% because previous studies demonstrated that adding only 5 wt% bioactive glass to PCL can already generate relevant in vitro and in vivo outcomes with respect to PCL only [55]. In particular, the focus of this work is the development of composite fibers with suitable properties for applications in soft tissue engineering, as widely reported [47][48][49][50] and it is not oriented to the osteogenic differentiation as reported in [55].…”

Section: Solution Preparationmentioning

confidence: 99%

Incorporation of Bioactive Glasses Containing Mg, Sr, and Zn in Electrospun PCL Fibers by Using Benign Solvents

et al. 2020

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Poly(ε-caprolactone) (PCL) and PCL/bioactive glass composite fiber mats were produced by electrospinning technique. To improve cell adhesion and proliferation (i) 45S5, (ii) a bioactive glass containing strontium and magnesium oxides, and (iii) a bioactive glass containing zinc oxide were separately added to the starting PCL solution before electrospinning. A good incorporation of bioactive glass particles in PCL electrospun mats was confirmed by SEM and FTIR analyses. Bioactivity was evaluated by immersion of PCL mats and PCL/bioactive glass electrospun fiber mats in simulated body fluid (SBF). Bone murine stromal cells (ST-2) were employed in WST-8 assay to assess cell viability, cell morphology, and proliferation. The results showed that the presence of bioactive glass particles in the fibers enhances cell adhesion and proliferation compared to neat PCL mats. Furthermore, PCL/bioactive glass electrospun mats showed higher wound-healing rate (measured as cell migration rate) in vitro compared to neat PCL electrospun mats. Therefore, the characteristics of the PCL matrix combined with biological properties of bioactive glasses make PCL/bioactive glass composite ideal candidate for biomedical application.

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“…Currently, many researchers focus on combinations of synthetic polymer materials, natural polymer materials, and bioactive ceramics to prepare composite materials for tissue engineering and regeneration [49,50,51], not only making up for hydrophobicity and the lack of adhesive ligands of synthetic polymers, but also resolving the readily degradable and structurally unstable disadvantages of natural polymers, and most importantly, enhancing the proliferation and differentiation of cells. In this study, gelatin with high biocompatibility was utilized as the dispersant, different from other dispersants such as polyvinyl alcohol, toluene, and Tween, which made the preparation process safer and more concise.…”

Section: Resultsmentioning

confidence: 99%

Design and Biophysical Characterization of Poly (l-Lactic) Acid Microcarriers with and without Modification of Chitosan and Nanohydroxyapatite

Song

Chen

et al. 2018

Polymers

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Nowadays, microcarriers are widely utilized in drug delivery, defect filling, and cell culture. Also, many researchers focus on the combination of synthetic and natural polymers and bioactive ceramics to prepare composite biomaterials for tissue engineering and regeneration. In this study, three kinds of microcarriers were prepared based on physical doping and surface modification, named Poly (l-lactic) acid (PLLA), PLLA/nanohydroxyapatite (PLLA/nHA), and PLLA/nHA/Chitosan (PLLA/nHA/Ch). The physicochemical properties of the microcarriers and their functional performances in MC3T3-E1 cell culture were compared. Statistical results showed that the average diameter of PLLA microcarriers was 291.9 ± 30.7 μm, and that of PLLA/nHA and PLLA/nHA/Ch microcarriers decreased to 275.7 ± 30.6 μm and 269.4 ± 26.3 μm, respectively. The surface roughness and protein adsorption of microcarriers were enhanced with the doping of nHA and coating of chitosan. The cell-carrier cultivation stated that the PLLA/nHA microcarriers had the greatest proliferation-promoting effect, while the PLLA/nHA/Ch microcarriers performed the strongest attachment with MC3T3-E1 cells. Besides, the cells on the PLLA/nHA/Ch microcarriers exhibited optimal osteogenic expression. Generally, chitosan was found to improve microcarriers with superior characteristics in cell adhesion and differentiation, and nanohydroxyapatite was beneficial for microcarriers regarding sphericity and cell proliferation. Overall, the modified microcarriers may be considered as a promising tool for bone tissue engineering.

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Mechanical, material, and biological study of a PCL/bioactive glass bone scaffold: Importance of viscoelasticity

Cited by 61 publications

References 62 publications

Fractional viscoelastic models for power-law materials

Fractional viscoelastic models for power-law materials

Incorporation of Bioactive Glasses Containing Mg, Sr, and Zn in Electrospun PCL Fibers by Using Benign Solvents

Design and Biophysical Characterization of Poly (l-Lactic) Acid Microcarriers with and without Modification of Chitosan and Nanohydroxyapatite

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