Mechanical/optical behaviors of imogolite hydrogels depending on their compositions and oriented structures

Shikinaka, Kazuhiro; Koizumi, Yumi; Shigehara, Kiyotaka

doi:10.1002/app.41691

Cited by 26 publications

(36 citation statements)

References 26 publications

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“…Currently, the mechanical-strain-induced strategy mainly focuses on the preparation of ordered structures of 1D nanotubes and 2D nanosheets within hydrogel matrixes, and these reported nanocomposite hydrogel materials exhibit anisotropic optical and mechanical performances. [81][82][83][84][85][86] Under tensile strain, polyacrylamide chains and 1D imogolite nanotubes in hydrogels were aligned, resulting in the formation of aligned internal structures (Figure 5a). [81,82] The obtained nanocomposite hydrogels, which had aligned structures, displayed strongly anisotropic mechanical/optical behaviors.…”

Section: Mechanical Strainmentioning

confidence: 99%

“…[81][82][83][84][85][86] Under tensile strain, polyacrylamide chains and 1D imogolite nanotubes in hydrogels were aligned, resulting in the formation of aligned internal structures (Figure 5a). [81,82] The obtained nanocomposite hydrogels, which had aligned structures, displayed strongly anisotropic mechanical/optical behaviors. Ordered nanostructures in PNIPAM/ nanoclay composite hydrogels were also fabricated by using the same method.…”

Section: Mechanical Strainmentioning

confidence: 99%

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Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

et al. 2017

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In the human body, many soft tissues with hierarchically ordered composite structures, such as cartilage, skeletal muscle, the corneas, and blood vessels, exhibit highly anisotropic mechanical strength and functionality to adapt to complex environments. In artificial soft materials, hydrogels are analogous to these biological soft tissues due to their “soft and wet” properties, their biocompatibility, and their elastic performance. However, conventional hydrogel materials with unordered homogeneous structures inevitably lack high mechanical properties and anisotropic functional performances; thus, their further application is limited. Inspired by biological soft tissues with well‐ordered structures, researchers have increasingly investigated highly ordered nanocomposite hydrogels as functional biological engineering soft materials with unique mechanical, optical, and biological properties. These hydrogels incorporate long‐range ordered nanocomposite structures within hydrogel network matrixes. Here, the critical design criteria and the state‐of‐the‐art fabrication strategies of nanocomposite hydrogels with highly ordered structures are systemically reviewed. Then, recent progress in applications in the fields of soft actuators, tissue engineering, and sensors is highlighted. The future development and prospective application of highly ordered nanocomposite hydrogels are also discussed.

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Section: Mechanical Strainmentioning

confidence: 99%

Section: Mechanical Strainmentioning

confidence: 99%

Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

et al. 2017

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“…gives the excellent improvement of mechanical strength to organic polymers. Furthermore, these nanohybrids exhibit some special properties such as frame-resistance [3] and anisotropic mechanical/optical nature [7]. Recently, imogolite (later denoted IG), a rigid hollow cylindrical inorganic clay with the composition of (HO) 3 Al 2 O 3 SiOH [8][9][10][11][12], have received widespread attention because of their anisotropic molecular shapes with rigidity that further derived various functions and potential applications of its composite materials.…”

Section: Introductionmentioning

confidence: 99%

“…Nanohybrids consisted of inorganic nanofiller and organic molecules have been studied with the expectation of their usage for industrial applications [1][2][3][4][5][6][7]. Especially, an addition of inorganic nanofillers with anisotropic shape (rod, platelet etc.)…”

Section: Introductionmentioning

confidence: 99%

Nanohybrid film consisted of hydrophobized imogolite and various aliphatic polyesters

Shikinaka

Abe

Shigehara

2015

Polymer

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“…E as superfícies exteriores e interiores do IG são cobertas com Al (OH) 2 e Si (OH), respectivamente. Tem sido usada como componente de nanocompósitos inorgânico-orgânico, uma vez que estes grupos atuam na captura de prótons, pois a densidade de carga das superfícies de IG varia com o pH e a força iônica do meio aquoso [53]. Embora a IG tenha características de bom carreador de fármacos, devido ao tamanho dos nanotubos e das ligações que ela pode realizar, não há na literatura estudos que comprovem seu potencial para carreamento de fármacos.…”

Section: Forma Utilizada Fármaco Referênciaunclassified

Utilização de argilas fibrosas e tubulares para a liberação modificadas de fármacos: uma revisão

Silva¹,

Vilarinho²,

Barud

et al. 2016

Matéria (Rio J.)

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RESUMONas últimas décadas o uso de argilominerais nas áreas de Ciência e Engenharia de Materiais tem recebido notória atenção para a sua utilização no carreamento de fármacos. Dentre os diversos tipos de argilas, as fibrosas e as tubulares tem sido utilizadas na preparação de bionanocompósitos, devido as suas propriedades inerentes, como exemplo a elevada área superficial. Esta pesquisa visou o levantamento bibliográfico da utilização das argilas tubulares e fibrosas para o carreamento de fármacos. A busca por artigos foi realizado no banco de dados Web of Science, utilizando combinação dos termos: Fibrous Clay and drug delivery, Tubular Clay and drug delivery, Halloysite and drug delivery, Imogolite and drug delivery, Palygoskite and drug delivery e Sepiolite and drug delivery. Foram encontrados o total de 36 artigos durante a pesquisa. Observouse que a maioria dos artigos utilizam as argilas em combinação com outros materiais (com formação de compósitos e blendas), principalmente polímeros, a fim de expandir as propriedades que melhoram a vetorização de insumos farmacêuticos ativos (IFAs), tais como a modificação do tamanho dos poros, do pH, da energia de ligação entre as moléculas, entre outros. Assim, evidencia-se que o interesse pela utilização das argilas no campo terapêutico tem aumentado, mostrando a relevância de pesquisas na área de medicamentos e materiais.Palavras-chave: argila fibrosa, argila tubular, argilominerais, carreamento de fármacos. ABSTRACTIn recent decades the use of clay minerals in the areas of Materials Science and Engineering has received notable attention for its use in carrying of drugs. Among the various types of clay, and fibrous tubes have been used in the preparation of bionanocompósitos due to their inherent properties, for example high surface area. This research aimed a review at the literature of the use of tubular and fibrous clays for the carrying of drugs. The search for articles was conducted in the Web of Science database, using combination of terms: Fibrous Clay and drug delivery, Tubular Clay and drug delivery, Halloysite and drug delivery, imogolite and drug delivery, drug delivery and Palygoskite and Sepiolite and drug delivery. Found total of 36 articles during the search. It was observed that most of the clay articles used in combination with other materials (with formation of composites and blends), in particular polymers in order to extend the properties that improve the vectoring of active pharmaceutical ingredients (APIs), such as modification pore size, the pH, the binding energy between molecules, among others. Thus, it is clear that the interest in the use of clays in the therapeutic field has increased, showing the relevance of research in the area of drugs and materials.

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Mechanical/optical behaviors of imogolite hydrogels depending on their compositions and oriented structures

Cited by 26 publications

References 26 publications

Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

Nanohybrid film consisted of hydrophobized imogolite and various aliphatic polyesters

Utilização de argilas fibrosas e tubulares para a liberação modificadas de fármacos: uma revisão

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