Honeycomb core sandwich panels are widely recognized for their exceptional strength-to-weight ratio, making them ideal for various structural applications. Advancements in manufacturing, such as additive manufacturing, now allow the creation of complex cellular cores, offering significant advantages over traditional sandwich structures. In this study, conventional honeycomb core sandwich panels were modelled through computer-aided design software and manufactured with the Fused Deposition Modelling (FDM) technique. Nylon-based polyamide/carbon fiber (PA/CF) was used for the face sheet, while pure polylactic acid (PLA) served as the core material. Specimens were prepared according to ASTM standards to assess the bending properties of the panels. To investigate the impact of the core wall thicknesses, panels were produced with three thicknesses (1.5 mm, 2 mm, and 2.5 mm), finalized based on relative density ratios to optimize performance. Results show an 85% increase in face-sheet bending strength and a 90% increase in core shear strength with greater core wall thickness. Furthermore, beam deflection increased by 80% with thicker cores, and the load vs. deflection curve demonstrated improved load-carrying capability. These findings suggest that architected core structures can enhance bending properties, leading to more efficient designs for aerospace, automotive, and other structural applications.