Mechanical properties and bioactive surface modification via alkali-heat treatment of a porous Ti–18Nb–4Sn alloy for biomedical applications

Xiong, Jianyu; Li, Yuncang; Wang, Xiaojian; Hodgson, Peter; Wen, Cuié

doi:10.1016/j.actbio.2008.04.022

Cited by 97 publications

(48 citation statements)

References 27 publications

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“…In a recent study, SEM images of alkali-modified titanium alloy with heat treatment resulted in more detailed images than alkali modified titanium alloy without heat treatment 13) . Our SEM observations are in agreement with those of previous studies 9,13,14) . In another study, hierarchical nano-textured titanium alloy surface topographies, with titania nanostructures to mimic the hierarchical structure of bone tissues, were produced by etching followed by anodization 15) .…”

Section: Discussionsupporting

confidence: 83%

Bioactivity of Titanium Surface Nanostructures Following Chemical Processing and Heat Treatment

Komasa

Taguchi

et al. 2015

J. Hard Tissue Biology.

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Our previous research reports that NaOH treatment leads to the formation of a Ti-O-Na titanate layer on the titanium-6-aluminium-4-vanadium (Ti6Al4V) surface. However, this titanium nanosheets (TNS) hydrogel layer is so brittle that it easily detaches from the implant and can cause many problems, including degradation in the living body due to inhomogeneous composition distribution. The aims of the present study were to investigate combined alkali-treatment of Ti6Al4V alloy and then heated and evaluate the ability of this modified surface to affect osteogenic differentiation of rat bone marrow (RBM) cells, to increase the success rate of titanium implants. We fabricated TNS on titanium alloy surfaces by NaOH treatment prior to heat treatment at 600 °C, and determined RBM cell properties and differentiation potential on the surface in comparison to untreated control surfaces. The nanoscale network structures formed by alkali etching markedly enhanced RBM cell adhesion and osteogenic-related gene expression. Other cell behaviors, such as proliferation, alkaline phosphatase activity, osteocalcin deposition and mineralization, were markedly increased on the TNS-modified Ti6Al4V with heat treatment. Our results suggest that titanium implants modified with nanostructures promote osteogenic differentiation, which may improve the biointegration of these implants into the alveolar bone.

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Section: Discussionsupporting

confidence: 83%

Bioactivity of Titanium Surface Nanostructures Following Chemical Processing and Heat Treatment

Komasa

Taguchi

et al. 2015

J. Hard Tissue Biology.

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“…The alkali method treatment introduced by Kokubo has since then gathered interest. The morphological characterizations of alkali-treated titanium are well documented [15][16][17][18][19][20][21][22][23], whereas, only a few reports are available on the electrochemical characterization. Tamilselvi et al [24] reported the corrosion behavior of untreated titanium alloys in SBF solution.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of corrosion behavior of surface modified Ti–6Al–4V ELI alloy in hanks solution

2009

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The passive film behavior of Ti-6Al-4V ELI (Extra Low Interstitial) alloy after a chemical treatment followed by a thermal treatment was morphologically and electrochemically characterized. The surface morphological studies were carried out using scanning electron microscopy (SEM), electron dispersive X-ray analysis (EDAX), and Fourier Transformed-Infra Red (FT-IR) analysis to investigate the nucleation and growth of apatite on the chemically and thermally treated Ti-6Al-4V ELI alloy immersed for different durations in Hanks solution. Polarization and impedance spectroscopic (EIS) measurements were carried out in Hanks solution and the electrical parameters were obtained for the passive film using a nonlinear least square fitting (NLLS) method.

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“…The stiffness of solid Ti can be lowered by introducing a porous structure which is also favourable for osteoconductivity and osseointegration. Techniques such as foaming, replica, rapid prototyping or sintering with space holders have been reported in literature [18][19][20]. The latter presents advantages that makes it a preferred method for the fabrication of controlled porosity scaffolds.…”

Section: Introductionmentioning

confidence: 99%

“…These are easiness in handling Ti raw material, which is highly oxygen-reactive, lower-than-melting temperatures employed in its processing and a fine control on volumetric porosity that resembles that of natural structures such as bone, preferred in bioengineering substrates and without straight edges [21]. Shape holder materials such as ammonium hydrogen carbonate, urea, sodium fluoride and chloride, saccharose and PMMA have been used in the manufacture of porous materials to control porosity and pore size [20,[22][23][24]. Therefore the strength-to-weight ratio can be optimised to match the mechanical properties of bone and these cavities engineered to promote cell proliferation, which results in anchoring of the bone graft in place to minimise loosening in the mid-and long-term.…”

Section: Introductionmentioning

confidence: 99%

The effect of pore size and porosity on mechanical properties and biological response of porous titanium scaffolds

Torres-Sánchez

Mushref

Norrito

et al. 2017

Materials Science and Engineering: C

157

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The effect of pore size and porosity on elastic modulus, strength, cell attachment and cell proliferation was studied for Ti porous scaffolds manufactured via powder metallurgy and sintering. Porous scaffolds were prepared in two ranges of porosities so that their mechanical properties could mimic those of cortical and trabecular bone respectively.Space-holder engineered pore size distributions were carefully determined to study the impact that small changes in pore size may have on mechanical and biological behaviour. The Young's moduli and compressive strengths were correlated with the relative porosity.Linear, power and exponential regressions were studied to confirm the predictability in the characterisation of the manufactured scaffolds and therefore establish them as a design tool for customisation of devices to suit patients' needs. The correlations were stronger for the linear and the power law regressions and poor for the exponential regressions. The optimal pore microarchitecture (i.e. pore size and porosity) for scaffolds to be used in bone grafting for cortical bone was set to <212m with volumetric porosity values of 27-37%, and for trabecular tissues to 300-500m with volumetric porosity values of 54-58%. The pore size range 212-300m with volumetric porosity values of 38-56% was reported as the least favourable to cell proliferation in the longitudinal study of 12 days of incubation.

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Mechanical properties and bioactive surface modification via alkali-heat treatment of a porous Ti–18Nb–4Sn alloy for biomedical applications

Cited by 97 publications

References 27 publications

Bioactivity of Titanium Surface Nanostructures Following Chemical Processing and Heat Treatment

Bioactivity of Titanium Surface Nanostructures Following Chemical Processing and Heat Treatment

Evaluation of corrosion behavior of surface modified Ti–6Al–4V ELI alloy in hanks solution

The effect of pore size and porosity on mechanical properties and biological response of porous titanium scaffolds

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