Mechanical properties and biomedical applications of a nanotube hydroxyapatite-reduced graphene oxide composite

Baradaran, S.; Moghaddam, Ehsan; Basirun, Wan Jeffrey; Mehrali, Mehdi; Sookhakian, M.; Hamdi, M.; Moghaddam, Milad Rahimi; Alias, Yatimah

doi:10.1016/j.carbon.2013.11.054

Cited by 315 publications

(241 citation statements)

References 65 publications

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“…It is preferential substitution in the human bone known for its excellent bioactivity and osteoinductivity [41]. A vibration band located at 1640 cm −1 corresponds to the skeletal vibration of Gr due to aromatic sp 2 hybridized C=C vibration stretching [38,39,42], confirming its presence in the synthesized composite.…”

Section: Morphological Characterizationmentioning

confidence: 68%

“…5 indicating the characteristic absorption bands of natural hydroxyapatite at 463, 569 and 603 cm −1 , which are attributed to the P−O bending of phosphate groups [37]. The three absorption bands of the PO 4 3− group were clearly distinguished in the composite HAP/ Gr nanopowder at 1092, 1038 and 960 cm −1 , which corresponds to the O−P−O phosphate ions of the hydroxyl site [38,39]. The characteristic band at 3572 cm −1 and weak broad band at 634 cm −1 can be attributed to the stretching and vibrational modes of the structural OH − groups of the hydroxyapatite lattice [40].…”

Section: Morphological Characterizationmentioning

confidence: 85%

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Electrochemical synthesis of nanosized hydroxyapatite/graphene composite powder

Mišković‐Stanković¹,

Eraković²,

Jankovic³

et al. 2015

Carbon letters

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Electrochemical synthesis was employed to prepare a novel hydroxyapatite/graphene (HAP/ Gr) composite powder suitable for medical applications as a hard tissue implant (scaffold). The synthesis was performed in a homogeneous dispersion containing Na 2 H 2 EDTA·2H 2 O, NaH 2 PO 4 and CaCl 2 with a Ca/EDTA/PO 4 3− concentration ratio of 0.25/0.25/0.15M, along with 0.01 wt% added graphene nanosheets, at a current density of 137 mA cm −2 and pH value of 9.0. The field emission scanning electron microscopy and transmission electron microscopy observations of the composite HAP/Gr powder indicated that nanosized hydroxyapatite particles were uniformly placed in the graphene overlay. Raman spectroscopy, Fourier transform infrared spectroscopy and X-ray diffraction confirmed graphene incorporation in the HAP/Gr powder. The electrochemically prepared HAP/Gr composite powder exhibited slight antibacterial effect against the growth of the bacterial strain Staphylococcus aureus.

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Section: Morphological Characterizationmentioning

confidence: 68%

Section: Morphological Characterizationmentioning

confidence: 85%

Electrochemical synthesis of nanosized hydroxyapatite/graphene composite powder

Mišković‐Stanković¹,

Eraković²,

Jankovic³

et al. 2015

Carbon letters

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“…The addition of GO to the coating of HAp increases the strength [116]. Moreover, the coating with modified GO offered resistance to corrosion and it was also possible to increase the elastic module of HAp and fracture toughness [117,118]. Incorporation of GO nanoflakes in the scaffolds of gelatin and HAp produced compressive strengths and the yield was also increased compared to gelatin/HAp [119].…”

Section: Graphene In Biomedical Implantationmentioning

confidence: 86%

“…Notably, the properties of HAp and bioglass can be influenced by rGO which depends on the concentration. The improvements of mechanical properties of the bioceramic materials by graphene and other related materials are done by bridging, sheet pullout and three-dimensional crack deflection mechanisms [118,122,123]. The graphene has a surface area for contact.…”

Section: Graphene In Biomedical Implantationmentioning

confidence: 99%

Graphene and graphene oxide as nanomaterials for medicine and biology application

et al. 2018

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Graphene-and graphene oxide-based nanomaterials have gained broad interests in research because of their unique physiochemical properties. The 2D allotropic structure allows it to be used in various biological fields. The biomedical applications of graphene and its composite include its use in gene and small molecular drug delivery. It is further used for biofunctionalization of protein, in anticancer therapy, as an antimicrobial agent for bone and teeth implantation. The biocompatibility of the newly synthesized nanomaterials allows its substantial use in medicine and biology. The current review summarizes the chemical structure and biological application of graphene in various fields.

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“…Due to their ultra-high mechanical strength over most other materials, carbon nanostructures (include carbon nanotubes, carbon nanofibers, graphene, nanodiamond (ND), and so forth) are effective additives to improve the mechanical properties of orthopedic materials. 50 Baradaran et al 93 fabricated reduced graphene oxide (rGO)-reinforced HA (nanotube) composites using a hydrothermal process. They showed improved elastic modulus and fracture toughness of the sintered samples with increasing of the rGO content.…”

mentioning

confidence: 99%

Nanomedicine applications in orthopedic medicine: state of the art

Mazaheri¹,

Eslahi²,

Ordikhani³

et al. 2015

IJN

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The technological and clinical need for orthopedic replacement materials has led to significant advances in the field of nanomedicine, which embraces the breadth of nanotechnology from pharmacological agents and surface modification through to regulation and toxicology. A variety of nanostructures with unique chemical, physical, and biological properties have been engineered to improve the functionality and reliability of implantable medical devices. However, mimicking living bone tissue is still a challenge. The scope of this review is to highlight the most recent accomplishments and trends in designing nanomaterials and their applications in orthopedics with an outline on future directions and challenges.

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Mechanical properties and biomedical applications of a nanotube hydroxyapatite-reduced graphene oxide composite

Cited by 315 publications

References 65 publications

Electrochemical synthesis of nanosized hydroxyapatite/graphene composite powder

Electrochemical synthesis of nanosized hydroxyapatite/graphene composite powder

Graphene and graphene oxide as nanomaterials for medicine and biology application

Nanomedicine applications in orthopedic medicine: state of the art

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