Mechanical properties and composition of carotid and femoral atherosclerotic plaques: A comparative study

Cunnane, Eoghan M.; Mulvihill, John J.; Barrett, Hilary E.; Hennessy, Mairéad M.; Kavanagh, Eamon G.; Walsh, Michael T.

doi:10.1016/j.jbiomech.2016.09.036

Cited by 31 publications

(17 citation statements)

References 47 publications

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“…TS could reflect the tensile response in circumference [11]. (2) The mechanical stretch can induce structural changes in the arterial wall, including VSMC hyperplasia and hypertrophy, as well as increased deposition of ECM collagen and elastin and result in arterial remodeling [19,20]. On the other hand, the arterial remodeling could act on its mechanical properties [21,22].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Assessment of Tensile Stress in Carotid Arteries of Healthy Human Subjects with Varying Age

Luo

et al. 2019

Preprint

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Background: Arterial remodeling is thought to reflect the adaptation of the vessel wall to mechanical and hemodynamic stimuli and contributes to the progression of cardiovascular and cerebrovascular diseases. Tensile stress (TS) is one of the mechanical properties of the artery wall. The purpose of this study was to investigate the tensile stress change (TS) of carotid artery with varying viscoelasticity in healthy subjects within two groups of different ages. Methods: Forty-five subjects were recruited and randomly assigned into the group at the age above 50 years and below 50 years. The carotid arteries were examined by ultrasonography, using the techniques of shear wave elastography (SWE), shear wave dispersion (SWD) and radiofrequency (RF) -based ultrasound. The following values, including elastic modulus (SWER) and viscous index (SWDR), as well as the peak and mean TS of the left and right carotid arteries (L-PTS, R-PTS, L-MTS and R-MTS) were measured. The correlations between SWER, SWDR and tensile stress were evaluated by using what correlation method.Results: The SWER and SWDR of carotid arteries are lower in the subjects ≥50 years old than the subjects younger than 50 years (SWER, 10.29±9.57 kPa VS 17.24±14.07 kPa; SWDR, 11.99±3.51 (m/s)/kHz VS 13.97±3.71 (m/s)/kHz, P< 0.05). The R-PTS was lower in the group with younger age (P<0.05). Pearson correlation analysis showed that SWER of carotid artery was positively correlated with the parameters of tensile stress，R-PTS, R-MTS, L-PTS and L-MTS( r=0.218, r=0.359, r=0.209 and r=0.369, respectively, P<0.05). However, SWDR of carotid arteries was not significantly associated with TS.Conclusion: Ultrasonic shear wave imaging could be used to quantitatively assess carotid viscoelasticity. The carotid TS was related to its elasticity while little related to its viscosity, suggesting that mechanical properties of the arterial wall might be better revealed.

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Section: Discussionmentioning

confidence: 99%

Ultrasound Assessment of Tensile Stress in Carotid Arteries of Healthy Human Subjects with Varying Age

Luo

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of tensile stress in carotid artery: evidence from ultrasonography

Luo

et al. 2019

Preprint

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“…Two separate moduli are calculated using the slopes of the linear portions of the mechanical response curve in the low-and highstrain regions. The transition point between low and high strain is defined as the point of the stress-strain curve with the maximum normal distance from the global secant, the line spanning from the origin to the end of the curve (Holzapfel, 2006;Cunnane et al, 2016). This equates to dividing the curve into three equal parts and treating the initial and final thirds of the curve as the low-and high-strain regions respectively.…”

Section: Mechanical Characterizationmentioning

confidence: 99%

Development of a Semi-Automated, Bulk Seeding Device for Large Animal Model Implantation of Tissue Engineered Vascular Grafts

Cunnane

Lorentz

Soletti

et al. 2020

Front. Bioeng. Biotechnol.

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Mechanical properties and composition of carotid and femoral atherosclerotic plaques: A comparative study

Cited by 31 publications

References 47 publications

Ultrasound Assessment of Tensile Stress in Carotid Arteries of Healthy Human Subjects with Varying Age

Ultrasound Assessment of Tensile Stress in Carotid Arteries of Healthy Human Subjects with Varying Age

Evaluation of tensile stress in carotid artery: evidence from ultrasonography

Development of a Semi-Automated, Bulk Seeding Device for Large Animal Model Implantation of Tissue Engineered Vascular Grafts

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