In this study, Al-Zn-Mg-Cu alloy was refill friction spot welded, and the precipitates, dislocation, recovery, and recrystallization characteristics were focused. In the stir zone (SZ), continues dynamic recrystallization occurs under the intense plastic deformation. All the original GP (II) zones and η' precipitates dissolved into the aluminum matrix under the welding heat input, and the stable η and E precipitates remained. In the thermo-mechanically affected zone (TMAZ), high-density dislocations and subgrains boundaries can be observed. The continued dynamic recrystallization was not activated and only dynamic recovery occurs. Sub-boundaries and high-density dislocations in this zone can be observed. In this zone, the η precipitates are coarsened and dissolution is the main evolution mechanism for the GP (II) zones and η' precipitates. In the heat-affected zone (HAZ), no dislocation was induced and all the initial precipitates were coarsened under the welding heat input. The HAZ, the TMAZ, and the SZ constitute a soft region in the refill friction stir spot welding (RFSSW) joint, and the minimum value located at the interface between the HAZ and the TMAZ.