Mechanical Properties and in Vitro and in Vivo Biocompatibility of a-C/a-C:Ti Nanomultilayer Films on Ti6Al4V Alloy as Medical Implants

Abstract

Hydrogen-free a-C/a-C:Ti nanomultilayer films are deposited on medical Ti6Al4V alloy using a closed field unbalanced magnetron sputtering under graded bias voltage. The mechanical and tribological properties of the nanomultilayer films are performed on the nanoindentor, Rockwell and scratch tests, and ball-on-disk tribometer. The biological properties are evaluated by cell cytotoxicity, genotoxicity, subchronic systemic toxicity and implant. The hard a-C/a-C:Ti nanomultilayer films on medical alloy exhibit high adhesion strength and excellent tribological properties in both ambient air and Hank's solution. Biocompatibility results reveal the film no cytotoxity, no genotoxicity, no subchronic systemic toxicity and no contraindications in implant systems. Because of excellent mechanical properties and biosafety, the carbon-based films on medical alloy unveils a prospective application in medical implants.

Triggering of Apoptosis in Osteosarcoma 143B Cell Line by Carbon Quantum Dots via the Mitochondrial Apoptotic Signal Pathway

“…Blood chemistry analysis and complete blood panel tests were within reference ranges for healthy mice. These pieces of data coincide with the studies of other nanomaterials [ 52 – 54 ]. However, the ALT, AST, and Cr values were lower in CQDs groups compared to the control group.…”

TEM Structure, Nanomechanical Property, and Adhesive Force of Magnetron-Sputtered Cr-DLC Coating on a Nitrided Ti6Al4V Alloy

“…Moreover, Jelinek et al reported that the adhesion layer of the DLC coating to the substrate improved with the doping of Cr, and the highest critical load also increased compared with that of the non-doped DLC coating. From the above findings, it is concluded that the mechanical properties of DLC coatings are enhanced by the doping of Cr, and the CrN interlayer effectively improves the adhesive force of the Cr-DLC coating at the bonding interface, which displayed graded and multilayered structures with high hardness and adhesive force for the Cr-DLC coating . Therefore, the transition metal nitride of CrN has become one of the most popular interlayers for the Cr-DLC coating …”

“…From the above findings, it is concluded that the mechanical properties of DLC coatings are enhanced by the doping of Cr, and the CrN interlayer effectively improves the adhesive force of the Cr-DLC coating at the bonding interface, which displayed graded and multilayered structures with high hardness and adhesive force for the Cr-DLC coating. 16 Therefore, the transition metal nitride of CrN has become one of the most popular interlayers for the Cr-DLC coating. 17 Another obstacle for the DLC coatings deposited on the TA was the mismatch of mechanical properties between the DLC coating and the TA.…”

Multislice Spiral CT Imaging Localization and Nursing Care of Catheter Fracture of Scalp Vein Indwelling Needle

“…In view of this research problem, Li, L. et al proposed that scalp vein indwelling needles should be more widely used in clinical practice, and sealing fluid is the key to maintaining patencies. In order to reduce blockage, it is best to choose 25 heparin/ml of normal saline as the sealing fluid, but for diseases such as thrombocytopenia, hemophilia, and children allergic to hepatologists, heparin should not be used, normal saline can be used as a sealing fluid [ 4 ]. According to Keiichi et al, the incidence of tube plugging was significantly reduced (17%) by pushing the sealing liquid while retreating the needle, compared with pulling the needle out after the injection (inserting the needle into the trocar 3 mm ∼ SMLN).…”