The Wudongde reservoir region exhibits a notable prevalence of landslides within the red-bed reservoir stratum. The red bed is a clastic sedimentary rock layer dominated by red continental deposits. It is mainly composed of sandstone, mudstone, and siltstone. The lithology is diverse and uneven. In this study, we delve into the impact of mineral dissolution on the development of red-bed landslides in the reservoir area by utilizing the Xiaochatou landslide as a representative case study. Considering the inherent susceptibility of red-bed formations to erosion, collapse, and softening when exposed to water, an investigation was conducted to examine the consequences of mineral dissolution on landslides occurring in these areas. We conducted a mineral analysis and an identification of rock samples from the Xiaochatou landslide site, revealing alternating layers of sandstone and mudstone. Sandstone and conglomerate specimens were immersed in deionized water, and advanced techniques such as scanning electron microscopy (SEM), ion chromatography (IC), and inductively coupled plasma (ICP) analysis were used to examine the effects of water immersion. We also employed the hydrogeochemical simulation software PHREEQC to understand the dissolution mechanism of gypsum during soaking. Our findings reveal that sandstone and conglomerates harbor a notable quantity of gypsum, which readily dissolves in water. Prolonged immersion leads to erosion cavities within the sandstone, thereby augmenting its permeability. The concentration of SO42− ions in the soaking solution emerges as the highest, followed by Ca2+ and Na+. The notable significance is the dissolution of gypsum, whose intricate mechanism is contingent upon diverse environmental conditions. Variations in ion concentration profoundly influence the saturation index (SI) value, with the pH value playing a crucial role in shifting the reaction equilibrium. Regarding the deformation mode of the landslide, it manifests as a combination of sliding compression and tension cracking. The fracture surface of the landslide assumes a step-like configuration. As the deformation progresses, the mudstone layer takes control over the sliding process, causing the sandstone to develop internal narrow-top and wide-bottom cracks, which propagate upward until the stability of the slope rock mass is compromised, resulting in its rupture. In this manuscript, we delve into the dissolution traits of red-bed soft rock in the Wudongde reservoir area, using a landslide case as a reference. We simulate this rock’s dissolution under environmental water influences, examining its interaction with diverse water types through rigorous experiments and simulations. This study’s importance lies in its potential to shed light on the crucial engineering characteristics of red-bed soft rock.