Mechanical properties and shape memory effect of 3D-printed PLA-based porous scaffolds

Сенатов, Ф.С.; Niaza, K.V.; Zadorozhnyy, M.Yu.; Maksimkin, Aleksey V.; Kaloshkin, S.D.; Estrin, Yuri

doi:10.1016/j.jmbbm.2015.11.036

Cited by 440 publications

(300 citation statements)

References 57 publications

Supporting

Mentioning

288

Contrasting

Unclassified

Order By: Relevance

“…Rapid prototyping structures shows mechanical properties significantly higher than those structures fabricated by other well -known techniques such as solvent -casting and particle leaching, thermal-induced phase separation and gas foaming, among others [4][5][6][7][8]. In this work 3D-printing as an actively developing method for formation of polymer implants was used to produce highly-porous scaffold [1].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

3D-printed scaffolds based on PLA/HA nanocomposites for trabecular bone reconstruction

Niaza

Сенатов

Kaloshkin

et al. 2016

J. Phys.: Conf. Ser.

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

“…Polylactide (PLA) is a bioresorbable polymer which is widely used for medical applications, especially bone implants [1]. Some works [2,3] revealed the need to reinforce PLA matrix to reach mechanical properties of human bone tissue.…”

Section: Introductionmentioning

confidence: 99%

3D-printed scaffolds based on PLA/HA nanocomposites for trabecular bone reconstruction

Niaza

Сенатов

Kaloshkin

et al. 2016

J. Phys.: Conf. Ser.

View full text Add to dashboard Cite

“…Previous reports suggested the need for using high temperatures [220 o C (8), 210 o C (9) and 250 o C (7)] when PVA based dosage forms were fabricated using FDM 3D printers. Moreover, several examples of PLA printed stuctures employed a temperature range of 180-210 o C (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets

et al. 2016

View full text Add to dashboard Cite

2 ABSTRACTPurpose. The fabrication of a ready-to-use immediate release tablets via 3D printing provides a powerful tool to on-demand individualization of dosage form. This work aims to adapt a widely used pharmaceutical grade polymer, polyvinylpyrrolidone (PVP), for instant on-demand production of immediate release tablets via FDM 3D printing.Methods. Dipyridamole or theophylline loaded filaments were produced via processing a physical mixture of API (10%) and PVP in the presence of plasticizer through hot-melt extrusion (HME). Computer software was utilized to design a capletshaped tablet. The surface morphology of the printed tablet was assessed using scanning electron microscopy (SEM). The physical form of drug and its integrity following an FDM 3D printing were assessed using x-ray powder diffractometry (XRPD), thermal analysis and HPLC. In vitro drug release studies for all 3D printed tablets were conducted in a USP II dissolution apparatus.Results. Bridging 3D printing process with HME in the presence of a thermostable filler, talc, enabled the fabrication immediate release tablets at temperatures as low as 110 o C. The integrity of two models drugs was maintained following HME and FDM 3D printing. XRPD indicated that a portion of the loaded theophylline remained crystalline in the tablet. The fabricated tablets demonstrated excellent mechanical properties, acceptable in-batch variability and an immediate in vitro release pattern. Conclusions.Combining the advantages of PVP as an impeding polymer with FDM 3D printing at low temperatures, this approach holds a potential in expanding the spectrum of drugs that could be used in FDM 3D printing for on demand manufacturing of individualised dosage forms.

show abstract

“…In spite of these advantages, PLA's strength level is notably inferior to Ti and PEEK cage, and it is difficult to define proper degradation rate that can ensures sufficient support during the healing and fusion process of the bone [8]. The advancement in fabrication technology has gave birth to 3D rapid prototyping, which allowed the consumer for cheaper and more complex cage design using PLA [9], [10]. In order to exploit these modern fabrication technique, it is important to understand the effect of different polymer materials used as PLIF cage to the stress behavior of implanted vertebral bone.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical Comparison of Polymeric Spinal Cages Using Ct Based Finite Element Method

Jalil¹,

Mazlan²,

Todo³

2017

IJBBB

View full text Add to dashboard Cite

Abstract:Interbody fusion devices are gaining acceptance as a treatment method of mainly for disc degeneration diseases and other medical conditions. Posterior lumbar interbody fusion (PLIF) cage is used in the procedure to maintain stability and promote fusion between vertebrae. Poly lactic acid (PLA) is assumed to be the alternative material which could provide cheaper material and lower production cost. However, these implants often cause subsidence failure at the endplate, resulting in injury risk and mechanical instability during fusion. In this study, the stress behavior of PLIF cage made by two different materials, Polyether ether ketone (PEEK) and PLA; was studied using finite element method (FEM). By implementing bilateral cages between vertebral bone L4 and L5, and conducting 6 different motion activities onto the model, the stress distribution of L4-L5, and cage bodies was predicted. Simulation results predicted that the cage subsidence occurred at both materials, with an overall of higher cage-endplate stresses for PEEK, in comparison to PLA and controlled configurations. In addition, the stress distribution in PLA cage was better and the maximum von Mises stress was approximately 3 times lower than PEEK cage. Further investigation of PLA cage's mechanical properties should be done experimentally to determine the accuracy and reliability of the simulation.

show abstract

Mechanical properties and shape memory effect of 3D-printed PLA-based porous scaffolds

Cited by 440 publications

References 57 publications

3D-printed scaffolds based on PLA/HA nanocomposites for trabecular bone reconstruction

3D-printed scaffolds based on PLA/HA nanocomposites for trabecular bone reconstruction

A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets

Biomechanical Comparison of Polymeric Spinal Cages Using Ct Based Finite Element Method

Contact Info

Product

Resources

About