Mechanical properties of collagen fibres: a comparison of reconstituted and rat tail tendon fibres

Kato, Yasushi; Christiansen, David L.; Hahn, Rita A.; Shieh, S J; Goldstein, Jack D.; Silver, Frederick H.

doi:10.1016/0142-9612(89)90007-0

Cited by 265 publications

(176 citation statements)

References 16 publications

Supporting

Mentioning

158

Contrasting

Unclassified

Order By: Relevance

“…The deformation mechanism of tendons is similar to those of crystalline polymers that yield and undergo plastic flow [257][258][259][260][261][262][263][264][265]. The yielding mechanism involves some form of flow, such as interfibrillar slippage, which is crucial in the tensile deformation of tendons [266,267].…”

Section: Mechanical Properties Of Tendon Tissuementioning

confidence: 99%

“…At strains beyond 2% strain, the low modulus of the toe region gives rise to the nonlinear heel region, during which reorientation and un-crimping of the collagen fibrils and stretching of the triple helix, the non-helical ends and the cross-links takes place [269,271,283]. When collagen is stretched beyond the heel region, no further extension is possible [259,270,284,285], the wavy pattern is now straightened and cross-links and fibrils start breaking [261]. To-date, advances in chemistry and engineering have made available numerous polymers, cross-linking systems and scaffold fabrication technologies that closely imitate the biomechanical properties of native tendons (Table 3).…”

Section: Mechanical Properties Of Tendon Tissuementioning

confidence: 99%

“…However, such scaffold conformations cannot provide adequate mechanical resistance, in such a high mechanical demand environment [356]. Using a wet extrusion system, micro-scale collagen fibres (Figure 3) were first produced in late 1970's and since then numerous papers have demonstrated that this process gives rise to fibres with ultrastructure characteristics, physical and mechanical properties similar to native tendon [257,259,[357][358][359]. Further in vitro analysis demonstrated that such materials, largely attributed to their surface features, not only facilitate bidirectional cell alignment, but also maintain tenogenic phenotype in vitro [360].…”

Section: Bottom-up Approached For Tendon Repair Based On Natural In Omentioning

confidence: 99%

See 2 more Smart Citations

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

183

188

View full text Add to dashboard Cite

Section: Mechanical Properties Of Tendon Tissuementioning

confidence: 99%

Section: Mechanical Properties Of Tendon Tissuementioning

confidence: 99%

Section: Bottom-up Approached For Tendon Repair Based On Natural In Omentioning

confidence: 99%

See 1 more Smart Citation

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

183

188

View full text Add to dashboard Cite

“…Collagen Young's Modulus : Most reported values for the Young's modulus for collagen fibres lie in the range 200-570 MPa (Kato et al, 1988, Yang et al, 2008, Sasaki and Odajima, 1996, Gentleman et al, 2003, van der Rijt et al, 2006, Shen et al, 2008.…”

Section: Model Parametersmentioning

confidence: 99%

A structural model of passive skeletal muscle shows two reinforcement processes in resisting deformation

Gindre

Takaza

Moerman

et al. 2013

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

Passive skeletal muscle derives its structural response from the combination of the titin filaments in the muscle fibres, the collagen fibres in the connective tissue and incompressibility due to the high fluid content. Experiments have shown that skeletal muscle tissue presents a highly asymmetrical three-dimensional behaviour when passively loaded in tension or compression, but structural models predicting this are not available. The objective of this paper is to develop a mathematical model to study the internal mechanisms which resist externally applied deformation in skeletal muscle bulk. One cylindrical muscle fibre surrounded by connective tissue was considered. The collagenous fibres of the endomysium and perimysium were grouped and modelled as tension-only oriented wavy helices wrapped around the muscle fibre. The titin filaments are represented as non-linear tensiononly springs. The model calculates the force developed by the titin molecules and the collagen network when the muscle fibre undergoes an isochoric along-fibre stretch. The model was evaluated using a range of literature based input parameters and compared to the experimental fibre-direction stress-stretch data available. Results show the fibre direction non-linearity and tension/compression asymmetry are partially captured by this structural model. The titin filament load dominates at low tensile stretches, but for higher stretches the collagen network was responsible for most of the stiffness. The oblique and initially wavy collagen fibres account for the non-linear tensile response since, as the collagen fibres are being recruited, they straighten and re-orient. The main contribution of the model is that it shows that the overall compression/tension response is strongly influenced by a pressure term induced by the radial component of collagen fibre stretch acting on the incompressible muscle fibre. Thus for along-fibre tension or compression the model predicts that the collagen network contributes to overall muscle stiffness through two different mechanisms: 1) a longitudinal force directly opposing tension and 2) a pressure force on the muscle fibres resulting in an indirect longitudinal load. Although the model presented considers only a single muscle fibre and evaluation is limited to along-fibre loading, this is the first model to propose these two internal mechanisms for resisting externally applied deformation of skeletal muscle tissue.2

show abstract

“…The central role of collagen as the major structural protein of mammalian tissue, comprising approximately one-third of the total protein in mammalian organisms, has motivated a significant effort towards determining its mechanical properties at all levels, ranging from single monomers [1,2] and long-chain polymers [3,4] to a structural element within a (macroscopic) biological tissue [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

A constitutive model for fibrous tissues considering collagen fiber crimp

Cacho¹,

Elbischger²,

Rodrı́guez³

et al. 2007

International Journal of Non-Linear Mechanics

View full text Add to dashboard Cite

A micromechanically-based constitutive model for fibrous tissues is presented. The model considers the randomly crimped morphology of individual collagen fibers, a morphology typically seen in photomicrographs of tissue samples. It describes the relationship between the fiber endpoints and its arc-length in terms of a measurable quantity, which can be estimated from image data. The collective mechanical behavior of collagen fibers is presented in terms of an explicit expression for the strain-energy function, where a fiber-specific random variable is approximated by a Beta distribution. The model-related stress and elasticity tensors are provided. Two representative numerical examples are analyzed with the aim of demonstrating the peculiar mechanism of the constitutive model and quantifying the effect of parameter changes on the mechanical response. In particular, a fibrous tissue, assumed to be (nearly) incompressible, is subject to a uniaxial extension along the fiber direction, and, separately, to pure shear. It is shown that the fiber crimp model can reproduce several of the expected characteristics of fibrous tissues.

show abstract

Mechanical properties of collagen fibres: a comparison of reconstituted and rat tail tendon fibres

Cited by 265 publications

References 16 publications

The past, present and future in scaffold-based tendon treatments

The past, present and future in scaffold-based tendon treatments

A structural model of passive skeletal muscle shows two reinforcement processes in resisting deformation

A constitutive model for fibrous tissues considering collagen fiber crimp

Contact Info

Product

Resources

About