Mechanical properties of dense polylactic acid structures fabricated by three dimensional printing

Giordano, Russell; Wu, Benjamin M.; Borland, Scott W.; Cima, Linda G.; Sachs, Emanuel M.; Cima, Michael J.

doi:10.1163/156856297x00588

Cited by 361 publications

(157 citation statements)

References 2 publications

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“…To tackle this problem, computer-assisted-design and computerassisted-manufacture (CAD/CAM) techniques, a.k.a. solid freeform fabrication (SFF) or rapid prototyping, that have been widely used in modern manufacture industry, are adopted by the field of tissue engineering [3,[95][96][97][98]. However, the existing SFF techniques also have their limitations such as limited material selections, inadequate resolution, and structural heterogeneity due to the "pixel assembly" nature of these fabrication processes [2].…”

Section: Phase Separationmentioning

confidence: 99%

Biomimetic materials for tissue engineering

Peter

2008

Advanced Drug Delivery Reviews

1,213

819

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Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation. Biomaterials play a pivotal role as scaffolds to provide three-dimensional templates and synthetic extracellular-matrix environments for tissue regeneration. It is often beneficial for the scaffolds to mimic certain advantageous characteristics of the natural extracellular matrix, or developmental or would healing programs. This article reviews current biomimetic materials approaches in tissue engineering. These include synthesis to achieve certain compositions or properties similar to those of the extracellular matrix, novel processing technologies to achieve structural features mimicking the extracellular matrix on various levels, approaches to emulate cell-extracellular matrix interactions, and biologic delivery strategies to recapitulate a signaling cascade or developmental/would-healing program. The article also provides examples of enhanced cellular/tissue functions and regenerative outcomes, demonstrating the excitement and significance of the biomimetic materials for tissue engineering and regeneration.

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Section: Phase Separationmentioning

confidence: 99%

Biomimetic materials for tissue engineering

Peter

2008

Advanced Drug Delivery Reviews

1,213

819

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“…With regard to wearable products, like footwear, the most interesting properties are those related to health, since antimicrobial [6], antibacterial or controlled drug release properties can be conferred on the product. One of the main advantages of FDM 3D printing is that it allows thermoplastic polymers to be used [15], such as polylactic acid (PLA) [16] or acrylonitrile butadiene styrene (ABS) [17], which have been previously functionalised. The process to obtain this type of materials starts by adding an additive with certain properties to the polymeric pellets.…”

Section: Functionalised Materialsmentioning

confidence: 99%

3D printing of functional anatomical insoles

Davia-Aracil

Hinojo-Pérez

Jimeno-Morenilla

et al. 2018

Computers in Industry

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Abstract. Anatomical insoles and additions have a corrective action on the footwear user. They are intended to reduce and adequately distribute plantar pressure among support points, thus minimising the stress these points can undergo. Such customised components have traditionally been manufactured by subtractive techniques, i.e. by milling a sheet of material. Latest advances in additive manufacturing (AM) techniques and, in particular, the popularisation of 3D printing by fused deposition modelling (FDM), have opened new ways for the production of anatomical insoles. These technologies allow additional functionalities to be added, as for instance the use of materials with antimicrobial properties, or, at a structural level, zonal control in 3D design to increase cushioning capacity. The latter cannot be achieved by traditional manufacturing techniques, in that the inside of the element is not accessible. However, there are no CAD tools available for the design and production of insoles, which are specifically oriented to take advantage of the benefits that AM can bring about. This paper describes a new methodology intended for the functionalisation of anatomical insoles through a systematic approach. On the one hand, internal structures are automatically obtained by parametric design; on the other hand, the 3D geometry of the insole or addition is adequately processed so that it can be printed by FDM, thus circumventing the constraints of this production technique. Industry. 2018Industry. , 95: 38-53. doi:10.1016Industry. /j.compind.2017 Keywords This is a previous version of the article published in Computers in 3D Printing of Functional Anatomical InsolesAbstract. Anatomical insoles and additions have a corrective action on the footwear user. They are intended to reduce and adequately distribute plantar pressure among support points, thus minimising the stress these points can undergo. Such customised components have traditionally been manufactured by subtractive techniques, i.e. by milling a sheet of material. Latest advances in additive manufacturing (AM) techniques and, in particular, the popularisation of 3D printing by fused deposition modelling (FDM), have opened new ways for the production of anatomical insoles. These technologies allow additional functionalities to be added, as for instance the use of materials with antimicrobial properties, or, at a structural level, zonal control in 3D design to increase cushioning capacity. The latter cannot be achieved by traditional manufacturing techniques, in that the inside of the element is not accessible. However, there are no CAD tools available for the design and production of insoles, which are specifically oriented to take advantage of the benefits that AM can bring about. This paper describes a new methodology intended for the functionalisation of anatomical insoles through a systematic approach. On the one hand, internal structures are automatically obtained by parametric design; on the other hand, the 3D geometry of the insole or addition is adeq...

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“…Thus, the scaffold architecture can be adjusted and optimized to attain the adequate mechanical response, accelerate bone regeneration process, and guide bone formation with the anatomic cortical-trabecular structure [78] . Several RP techniques have been used for scaffolds preparation, such as robocasting (RC), selective laser sintering (SLS), selective laser melting (SLM), stereolithography (SLA) [79][80][81][82] , 3D printing (3DP) [83][84][85] and fused deposition modeling (FDM) [86,87] . Herein we reviewed the two main RP techniques, namely robocasting (RC) and selective laser based techniques as SLS and SLM, used for the manufacture of bioceramic and metallic scaffolds by itself or in combination with polymers.…”

Section: Scaffolds For Bone Tissue Engineeringmentioning

confidence: 99%

Preventing bacterial adhesion on scaffolds for bone tissue engineering

Sánchez‐Salcedo¹,

Colilla²,

Izquierdo‐Barba³

et al. 2024

IJB

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Abstract:Bone implant infection constitutes a major sanitary concern which is associated to high morbidity and health costs. This manuscript focused on overviewing the main research efforts committed up to date to develop innovative alternatives to conventional treatments, such as those with antibiotics. These strategies mainly rely on chemical modifications of the surface of biomaterials, such as providing it of zwitterionic nature, and tailoring the nanostructure surface of metal implants. These surface modifications have successfully allowed inhibition of bacterial adhesion, which is the first step to implant infection, and preventing long-term biofilm formation compared to pristine materials. These strategies could be easily applied to provide three-dimensional (3D) scaffolds based on bioceramics and metals, of which its manufacture using rapid prototyping techniques was reviewed. This opens the gates for the design and development of advanced 3D scaffolds for bone tissue engineering to prevent bone implant infections. Keywords: Antibacterial adhesion, biofilm formation, zwitterionic surfaces, nanostructured surfaces, rapid prototyping 3D scaffolds, bone tissue engineering.

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Mechanical properties of dense polylactic acid structures fabricated by three dimensional printing

Cited by 361 publications

References 2 publications

Biomimetic materials for tissue engineering

Biomimetic materials for tissue engineering

3D printing of functional anatomical insoles

Preventing bacterial adhesion on scaffolds for bone tissue engineering

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