Mechanical Properties of End-Linked PEG/PDMS Hydrogels

Cui, Jun; Lackey, Melissa A.; Tew, Gregory N.; Crosby, Alfred J.

doi:10.1021/ma300593g

Cited by 90 publications

(68 citation statements)

References 36 publications

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“…56,57,58 PEG and PS were chosen as model co-network components for several reasons. Many studies on PS-PEG block copolymers have been reported, and their phase behavior is well known.…”

Section: Resultsmentioning

confidence: 99%

Wide Bicontinuous Compositional Windows from Co-Networks Made with Telechelic Macromonomers

et al. 2014

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Phase-separated and self-assembled co-network materials offer a simple route to bicontinuous morphologies, which are expected to be highly beneficial for applications such as ion, charge, and oxygen transport. Despite these potential advantages, the programmed creation of co-network structures has not been achieved, largely due to the lack of well-controlled chemistries for their preparation. Here, a thiol-ene end-linking platform enables the systematic investigation of phase-separated poly(ethylene glycol) (PEG) and polystyrene (PS) networks in terms of the molecular weight and relative volume fractions of precursor polymers. The ion conductivity and storage modulus of these materials serve as probes to demonstrate that both phases percolate over a wide range of compositions, spanning PEG volume fractions from ∼0.3-0.65. Small angle X-ray scattering (SAXS) shows that microphase separation of these co-networks yields disordered structures with d-spacings that follow d∼Mn0.5, for 4.8 kg/mol

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“…56,57,58 PEG and PS were chosen as model co-network components for several reasons. Many studies on PS-PEG block copolymers have been reported, and their phase behavior is well known.…”

Section: Resultsmentioning

confidence: 99%

Wide Bicontinuous Compositional Windows from Co-Networks Made with Telechelic Macromonomers

et al. 2014

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“…combined linear PEG-norbornene with poly(dimethylsiloxane)-norbornene (PDMS-norbornene) and used tetra-functional PEGSH as cross-linker for UV light-mediated thiol-norbornene photopolymerization. 42-43 The resulting hydrogels are highly elastic and strong and should be useful for applications requiring high resilience and strength.…”

Section: Macromers Developed For Forming Thiol-norbornene Hydrogelsmentioning

confidence: 99%

Thiol–norbornene photoclick hydrogels for tissue engineering applications

Lin

Han

2014

J of Applied Polymer Sci

193

214

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Thiol-norbornene (thiol-ene) photo-click hydrogels have emerged as a diverse material system for tissue engineering applications. These hydrogels are cross-linked through light mediated orthogonal reactions between multi-functional norbornene-modified macromers (e.g., poly(ethylene glycol), hyaluronic acid, gelatin) and sulfhydryl-containing linkers (e.g., dithiothreitol, PEG-dithiol, bis-cysteine peptides) using low concentration of photoinitiator. The gelation of thiol-norbornene hydrogels can be initiated by long-wave UV light or visible light without additional co-initiator or co-monomer. The cross-linking and degradation behaviors of thiol-norbornene hydrogels are controlled through material selections, whereas the biophysical and biochemical properties of the gels are easily and independently tuned owing to the orthogonal reactivity between norbornene and thiol moieties. Uniquely, the cross-linking of step-growth thiol-norbornene hydrogels is not oxygen-inhibited, therefore the gelation is much faster and highly cytocompatible compared with chain-growth polymerized hydrogels using similar gelation conditions. These hydrogels have been prepared as tunable substrates for 2D cell culture, as microgels or bulk gels for affinity-based or protease-sensitive drug delivery, and as scaffolds for 3D cell culture. Reports from different laboratories have demonstrated the broad utility of thiol-norbornene hydrogels in tissue engineering and regenerative medicine applications, including valvular and vascular tissue engineering, liver and pancreas-related tissue engineering, neural regeneration, musculoskeletal (bone and cartilage) tissue regeneration, stem cell culture and differentiation, as well as cancer cell biology. This article provides an up-to-date overview on thiol-norbornene hydrogel cross-linking and degradation mechanisms, tunable material properties, as well as the use of thiol-norbornene hydrogels in drug delivery and tissue engineering applications.

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“…For this purpose, we reported the preparation of homogeneous amphiphilic gels by the cross-linking of hydrophilic tetra-arm poly(ethylene glycol) and hydrophobic linear poly(dimethylsiloxane) to form PEG−PDMS gels. 30 In contrast to the conventional way of copolymerization, 31 this reaction does not require cross-linkers. 32 Therefore, the resultant gels are homogeneous similar to the inhomogeneity-free gels we have reported using only tetra-arm PEG units.…”

Section: ■ Introductionmentioning

confidence: 99%

Fabrication and Structural Characterization of Module-Assembled Amphiphilic Conetwork Gels

et al. 2016

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Structural analysis of inhomogeneity-free poly(ethylene glycol)− poly(dimethylsiloxane) (PEG−PDMS) amphiphilic conetwork gels has been performed by the complementary use of small-angle X-ray and neutron scattering. Because of the hydrophobicity of PDMS units, the PEG−PDMS gels exhibit a microphase-separated structure in water. Depending on the volume fraction of PDMS, the microphase-separated structure varies from core−shell to lamellar. The obtained X-ray and neutron scattering profiles are reproduced well using a core− shell model together with a Percus−Yevick structure factor when the volume fraction of PDMS is small. The domain size is much larger than the size of individual PEG and PDMS unit, and this is explained using the theory of block copolymers. Reflecting the homogeneous dispersion conditions in the as-prepared state, scattering peaks are observed even at a very low PDMS volume fraction (0.2%). When the volume fraction of PDMS is large, the microphase-separated structure is lamellar and is demonstrated to be kinetically controlled by nonequilibrium and topological effects.

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Mechanical Properties of End-Linked PEG/PDMS Hydrogels

Cited by 90 publications

References 36 publications

Wide Bicontinuous Compositional Windows from Co-Networks Made with Telechelic Macromonomers

Wide Bicontinuous Compositional Windows from Co-Networks Made with Telechelic Macromonomers

Thiol–norbornene photoclick hydrogels for tissue engineering applications

Fabrication and Structural Characterization of Module-Assembled Amphiphilic Conetwork Gels

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