Mechanical Properties of Fresh, Frozen and Vitrified Articular Cartilage

Ead, Maha; Wu, Kezhou; Jar, Chester; Duke, Kajsa; Jomha, Nadr M.; Westover, Lindsey

doi:10.1007/s10439-023-03220-2

Ann Biomed Eng

2023

DOI: 10.1007/s10439-023-03220-2

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Mechanical Properties of Fresh, Frozen and Vitrified Articular Cartilage

Maha Ead

Kezhou Wu

Chester Jar

et al.

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2024

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Current State and Challenges of Tissue and Organ Cryopreservation in Biobanking

Khaydukova,

Ivannikova,

Zhidkov

et al. 2024

IJMS

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Recent years have witnessed significant advancements in the cryopreservation of various tissues and cells, yet several challenges persist. This review evaluates the current state of cryopreservation, focusing on contemporary methods, notable achievements, and ongoing difficulties. Techniques such as slow freezing and vitrification have enabled the successful preservation of diverse biological materials, including embryos and ovarian tissue, marking substantial progress in reproductive medicine and regenerative therapies. These achievements highlight improved post-thaw survival and functionality of cryopreserved samples. However, there are remaining challenges such as ice crystal formation, which can lead to cell damage, and the cryopreservation of larger, more complex tissues and organs. This review also explores the role of cryoprotectants and the importance of optimizing both cooling and warming rates to enhance preservation outcomes. Future research priorities include developing new cryoprotective agents, elucidating the mechanisms of cryoinjury, and refining protocols for preserving complex tissues and organs. This comprehensive overview underscores the transformative potential of cryopreservation in biomedicine, while emphasizing the necessity for ongoing innovation to address existing challenges.

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Current State and Challenges of Tissue and Organ Cryopreservation in Biobanking

Khaydukova,

Ivannikova,

Zhidkov

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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Mechanical Properties of Fresh, Frozen and Vitrified Articular Cartilage

Cited by 1 publication

References 49 publications

Current State and Challenges of Tissue and Organ Cryopreservation in Biobanking

Current State and Challenges of Tissue and Organ Cryopreservation in Biobanking

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