Mechanical properties of Gelatin Hydroxyapatite composite for bone tissue engineering

Hossan, MJ; Gafur, M. A.; Karim, MM; Rana, AA

doi:10.3329/bjsir.v50i1.23805

Cited by 37 publications

(35 citation statements)

References 12 publications

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“…These resultas are in accordance to those reported by Hossan et al They developed gelatinhydroxyapatite composites and revealed a dramatic increase in dimensional stability with 20 wt% [41].…”

Section: Figuresupporting

confidence: 92%

Manufacturing and characterization of poly(lactic acid) composites with hydroxyapatite

Ferri

Jordá

Muñoz

et al. 2017

Journal of Thermoplastic Composite Materials

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Hydroxyapatite (HA), a naturally occurring calcium orthophosphate, possesses the most similar chemical composition to human bone. In this research work, composite materials were prepared by using poly(lactic acid), PLA as a polymer matrix and hydroxyapatite as osteoconductive filler for potential uses in medical applications. Composites with varying hydroxyapatite content comprised in the 10-30 wt% range were obtained by extrusion-compounding followed by injection moulding. The effect of the HA loading on overall properties was assessed by mechanical characterization using tensile, flexural, impact and hardness standard tests. Main thermal transitions of PLA-HA composites were obtained by differential scanning calorimetry (DSC) and degradation/decomposition at high temperatures was followed by thermogravimetric analysis (TGA). Dynamical behavior was assessed by dynamical mechanical thermal analysis (DMTA) and the dimensional stability was studied by thermomechanical analysis (TMA). As per the results, PLA-HA composites with 20-30 wt% HA offer the best-balanced properties with a remarkable increase in the Young's modulus. The glass transition temperature (Tg) remained almost constant with slight changes of less than 1 ºC as measured by both differential scanning calorimetry (DSC) and thermomechanical analysis (TMA). TMA also revealed a remarkable decrease in the coefficient of linear thermal expansion. The overall results confirm the usefulness of these materials from a mechanical point of view for biomedical applications as they are characterized by high stiffness, tensile strength and dimensional stability.

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Section: Figuresupporting

confidence: 92%

Manufacturing and characterization of poly(lactic acid) composites with hydroxyapatite

Ferri

Jordá

Muñoz

et al. 2017

Journal of Thermoplastic Composite Materials

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“…Existing 3D culture models for osteogenesis and/or bone tissue regeneration rely on scaffolds made of collagen-derived gelatin [173], collagen–HA [174], ceramic materials, inorganic HA [175], chitosan, and alginate [176,177]. These scaffolds are a better model for bone tissue.…”

Section: Efficacy Evaluation Of Cap-based Bioceramicsmentioning

confidence: 99%

Comprehensive In Vitro Testing of Calcium Phosphate-Based Bioceramics with Orthopedic and Dentistry Applications

et al. 2019

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Recently, a large spectrum of biomaterials emerged, with emphasis on various pure, blended, or doped calcium phosphates (CaPs). Although basic cytocompatibility testing protocols are referred by International Organization for Standardization (ISO) 10993 (parts 1–22), rigorous in vitro testing using cutting-edge technologies should be carried out in order to fully understand the behavior of various biomaterials (whether in bulk or low-dimensional object form) and to better gauge their outcome when implanted. In this review, current molecular techniques are assessed for the in-depth characterization of angiogenic potential, osteogenic capability, and the modulation of oxidative stress and inflammation properties of CaPs and their cation- and/or anion-substituted derivatives. Using such techniques, mechanisms of action of these compounds can be deciphered, highlighting the signaling pathway activation, cross-talk, and modulation by microRNA expression, which in turn can safely pave the road toward a better filtering of the truly functional, application-ready innovative therapeutic bioceramic-based solutions.

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“…The combination of organic and inorganic components allows obtaining materials with good biocompatibility and osteoconductivity. The multicomponent Hap-based composites exhibit improved properties compared to their individual components [Hossan et al, 2015;Le et al, 2015;Constanda et al 2016]. To the best of our knowledge, no studies regarding three-component Hap-based composites were reported in the literature.…”

Section: Introductionmentioning

confidence: 95%

Hydroxyapatite - Carbon Nanotube Composites for Drug Delivery Applications

Barabáş

Rigo

Sárközi³

et al. 2019

Braz. J. Chem. Eng.

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The aim of this study was the synthesis of composites containing hydroxyapatite (Hap) or silicon substituted hydroxyapatite (HapSi), carboxyl functionalized carbon nanotubes (fMWCNT) and gelatin (G) in different ratios. Ibuprofen (IBU) was chosen as a model drug for the formulation of extended-release dosage forms. The obtained composites were characterized using X-ray diffraction, laser diffraction particle size analyzer, Brunauer-Emmett-Teller surface area measurements, transmission electron microscopy and Fourier transformed infrared spectroscopy. IBU adsorption and desorption was monitored by UV-VIS spectroscopy. The obtained results revealed that composites containing three components exhibit higher adsorption efficiency (Hap-fMWCNT-20G-82.7% and HapSi-fMWCNT-20G-84.6%) and extended-release of IBU, due to the chemical bonds between the carboxyl groups of IBU and the functional groups on the composite surface. The adsorption capacity of Hap composites is important for dental or orthopedic implants, the anti-inflammatory substances being adsorbed on their surface; but the adsorption capacity also enhances new bone formation (osteosynthesis) around the implants. These composites are thus attractive materials to be used in bone tissue engineering and drug delivery systems.

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Mechanical properties of Gelatin Hydroxyapatite composite for bone tissue engineering

Cited by 37 publications

References 12 publications

Manufacturing and characterization of poly(lactic acid) composites with hydroxyapatite

Manufacturing and characterization of poly(lactic acid) composites with hydroxyapatite

Comprehensive In Vitro Testing of Calcium Phosphate-Based Bioceramics with Orthopedic and Dentistry Applications

Hydroxyapatite - Carbon Nanotube Composites for Drug Delivery Applications

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Mechanical properties of Gelatin Hydroxyapatite composite for bone tissue engineering

Cited by 37 publications

References 12 publications

Manufacturing and characterization of poly(lactic acid) composites with hydroxyapatite

Manufacturing and characterization of poly(lactic acid) composites with hydroxyapatite

Comprehensive In Vitro Testing of Calcium Phosphate-Based Bioceramics with Orthopedic and Dentistry Applications

Hydroxyapatite - Carbon Nanotube Composites for Drug Delivery Applications

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Product

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Mechanical properties of Gelatin Hydroxyapatite composite for bone tissue engineering