Geothermal power is being regarded as depending on techniques derived from hydrocarbon production in worldwide current strategy. However, it has artificially been developed far less than its natural potentials due to technical restrictions. This paper introduces the Enhanced Geothermal System based on Excavation (EGS-E), which is an innovative scheme of geothermal energy extraction. Then, based on cohesion-weakening-friction-strengthening model (CWFS) and literature investigation of granite test at high temperature, the initiation, propagation of excavation damaged zones (EDZs) under unloading and the EDZs scale in EGS-E closed to hydrostatic pressure state is studied. Finally, we have a discussion about the further evolution of surrounding rock stress and EDZs during ventilation is studied by thermal-mechanical coupling. The results show that the influence of high temperature damage on the mechanical parameters of granite should be considered; Lateral pressure coefficient affects the fracture morphology and scale of tunnel surrounding rock, and EDZs area is larger when the lateral pressure coefficient is 1.0 or 1.2; Ventilation of high temperature and high in-situ stress tunnel have a significant effect on the EDZs scale; Additional tensile stress is generated in the shallow of tunnel surrounding rock, and the compressive stress concentration transfers to the deep. EDZs experiences three expansion stages of slow, rapid and deceleration with cooling time, and the thermal insulation layer prolongs the slow growth stage.