Mechanical properties of OI type III bone tissue measured by nanoindentation

Fan, Zaifeng; Smith, Peter A.; Eckstein, Eugene C.; Harris, Gerald F.

doi:10.1002/jbm.a.30713

Cited by 38 publications

(32 citation statements)

References 40 publications

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“…Furthermore, specimens in the current study were fresh-frozen and untreated, whereas those in the nanoindentation studies were dehydrated, a process that has been shown to increase modulus results [63–65]. Unlike previous data from a nanoindentation study, which suggested that OI bone may exhibit more isotropic properties than normal tissue [32], results from the current study demonstrated clear anisotropy in bone material properties at the mesoscale within this population, with the transverse properties being approximately equal to one third of their longitudinal counterparts. These observations indicate that the preferential orientation of the vascular porosity network is likely to play an important role in the anisotropic behavior of OI bone at the mesoscale.…”

Section: Discussionmentioning

confidence: 99%

“…Within that microstructural scale, the elastic modulus of bone tissue was found to be higher in children with severe or moderately severe OI (types III and IV) vs. age-matched controls [25], and this property was slightly higher in children with mild (type I) vs. severe (type III) OI [31]. Interestingly, contrary to observations in normal bone tissue [35–37], no significant difference in modulus was observed between indents taken parallel vs. perpendicular to the long bone axis [32], which led to the speculation that OI bone may exhibit more isotropic properties than does typical bone. These results confirm that bone material properties are affected in OI, however, important limitations with these studies should be acknowledged.…”

Section: Introductionmentioning

confidence: 99%

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Reduced diaphyseal strength associated with high intracortical vascular porosity within long bones of children with osteogenesis imperfecta

Albert

Jameson

Smith

et al. 2014

Bone

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Osteogenesis Imperfecta is a genetic disorder resulting in bone fragility. The mechanisms behind this fragility are not well understood. In addition to characteristic bone mass deficiencies, research suggests that bone material properties are compromised in individuals with this disorder. However, little data exists regarding bone properties beyond the microstructural scale in individuals with this disorder. Specimens were obtained from long bone diaphyses of nine children with osteogenesis imperfecta during routine osteotomy procedures. Small rectangular beams, oriented longitudinally and transversely to the diaphyseal axis, were machined from these specimens and elastic modulus, yield strength, and maximum strength were measured in three-point bending. Intracortical vascular porosity, bone volume fraction, osteocyte lacuna density, and volumetric tissue mineral density were determined by synchrotron micro-computed tomography, and relationships among these mechanical properties and structural parameters were explored. Modulus and strength were on average 64–68% lower in the transverse vs. longitudinal beams (P<0.001, linear mixed model). Vascular porosity ranged between 3–42% of total bone volume. Longitudinal properties were associated negatively with porosity (P≤0.006, linear regressions). Mechanical properties, however, were not associated with osteocyte lacuna density or volumetric tissue mineral density (P≥0.167). Bone properties and structural parameters were not associated significantly with donor age (p≥0.225, linear mixed models). This study presents novel data regarding bone material strength in children with osteogenesis imperfecta. Results confirm that these properties are anisotropic. Elevated vascular porosity was observed in most specimens, and this parameter was associated with reduced bone material strength. These results offer insight towards understanding bone fragility and the role of intracortical porosity on the strength of bone tissue in children with osteogenesis imperfecta.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reduced diaphyseal strength associated with high intracortical vascular porosity within long bones of children with osteogenesis imperfecta

Albert

Jameson

Smith

et al. 2014

Bone

View full text Add to dashboard Cite

show abstract

“…Under the influence of the anabolic effect of Sr, the slight decrease in bone hardness may result from the enhanced formation of a less mineralized new bone. E / H is useful in the evaluation of the overall deformation characteristics during indentation and is proportional to the fracture toughness of the bone [35]. Higher E / H values correspond to a more ductile material, while lower E / H values generally indicate a more brittle material.…”

Section: Discussionmentioning

confidence: 99%

Microarchitecture and Nanomechanical Properties of Trabecular Bone After Strontium Administration in Osteoporotic Goats

Peng

Pan

et al. 2011

Biol Trace Elem Res

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Strontium (Sr) ralenate is a new agent used for the prevention and treatment of osteoporosis. As a bone-seeking element, 98% of Sr is deposited in the bone and teeth after oral ingestion. However, the effect of Sr treatment on bone microarchitecture and bone nanomechanical properties remains unclear. In this study, 18 osteoporotic goats were divided into four groups according to the treatment regimen: control, calcium alone (Ca), calcium and Sr at 24 mg/kg (Ca + 24Sr), and calcium and Sr at 40 mg/kg (Ca + 40Sr). The effects of Sr administration on bone microarchitecture and nanomechanical properties of trabecular bones were analyzed with micro-CT and nanoindentation test, respectively. Serum Sr levels increased six- and tenfold in the Ca + 24Sr and Ca + 40Sr groups, respectively. Similarly, Sr in the bone increased four- and sixfold in these two groups. Sr administration significantly increased trabecular bone volume fraction, trabecular thickness, and double-labeled new bone area. Sr administration, however, did not significantly change the nanomechanical properties of trabecular bone (elastic modulus and hardness). The data suggested that Sr administration increased trabecular bone volume and improved the microarchitecture while maintaining the intrinsic tissue properties in the osteoporotic goat model.

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“…Although modern biomechanical assessments such as nanoindentation or scanning acoustic microscopy may provide microscopic mapping of the mechanical properties of bone,29, 30 the properties at the implant interface still cannot be directly measured. Thus, in this study we generated functional apparent moduli (FAMs) by simulating the implant loading situation and extrapolation via FE modeling to match the microscopic data.…”

Section: Discussionmentioning

confidence: 99%

Functional apparent moduli as predictors of oral implant osseointegration dynamics

et al. 2010

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At present, limited functional data exists regarding the application and use of biomechanical and imaging technologies for oral implant osseointegration assessment. The objective of this investigation was to determine the functional apparent moduli (FAMs) that could predict the dynamics of oral implant osseointegration. Using an in vivo dental implant osseous healing model, two FAMs, functional bone apparent modulus (FBAM) and composite tissue apparent modulus (FCAM), of the selected peri-implant structures were calculated via microcomputed tomography (micro-CT) and finite element (FE) simulations in order to support this concept. Results showed significant sensitivity between FAMs and micro-CT parameters, especially between bone mineral density and FBAM, while at extraction defect sites the strongest correlations existed between bone-implant contact and FCAM. Significant enhancement of FCAM indicated progressive functional repair during early osseointegration. Further, the resultant interfacial resistance was predicted by bone mineral content (BMC) and FBAM within a ~200 μm peri-implant thickness, while the extraction defects gave zones of ~575 μm and 200 μm for BMC and FCAM, respectively. These results suggest that the function of dental implant support can be predicted from a peri-implant structural zone. We conclude that FAMs can be used to predict the dynamics of dental implant osseointegration in vivo.

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Mechanical properties of OI type III bone tissue measured by nanoindentation

Cited by 38 publications

References 40 publications

Reduced diaphyseal strength associated with high intracortical vascular porosity within long bones of children with osteogenesis imperfecta

Reduced diaphyseal strength associated with high intracortical vascular porosity within long bones of children with osteogenesis imperfecta

Microarchitecture and Nanomechanical Properties of Trabecular Bone After Strontium Administration in Osteoporotic Goats

Functional apparent moduli as predictors of oral implant osseointegration dynamics

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