MECHANICAL PROPERTIES OF Β-Tricalcium PHOSPHATE CERAMICS DOPED WITH VANADATE IONS

Abstract

Beta-tricalcium phosphate (β-TCP) powders and ceramics doped with vanadate (VO 4 3-) ions were prepared, and the substitution mode of VO 4 3-ions for the β-TCP structure and the mechanical properties were investigated. The synthesized powders consisted of a single β-TCP (0-80 mol%) or Ca 3 (VO 4 ) 2 (100 mol%) phase, and the a and c lattice constants increased linearly up to 100 mol%. These results indicate that the VO 4 3-ions were homogeneously doped at all PO 4 sites in β-TCP. The bending strength increased with the VO 4 3-ion content up to 2.0 mol% because of the improvement in sinterability. However, when the VO 4 3-ion content was above 2.0 mol%, the bending strength decreased because of crack formation and porosity due to excess grain growth. The bending strength of β-TCP ceramics was higher when doped with VO 4 3-ions than with other metal ions; thus, β-TCP ceramics with excellent mechanical properties can be fabricated by substituting a small amount of VO 4 3-ions.

EVALUATION OF THE CELL CYTOTOXICITY OF ^|^beta;-TRICALCIUM PHOSPHATE DOPED WITH VANADIUM IONS

“…The lattice parameters of the a-axis and c-axis of V-β-TCPV increased very slightly with increasing vanadium ion content. The changes in the lattice parameters of the V-β-TCPV differed from those of the V-β-TCP 5 and β-TCPV 6 . FIGURE 3 FT-IR spectra of V-β-TCPV doped with 0-1.5 mol% of vanadium ions.…”

“…FIGURE 2 shows the lattice parameters of the samples. In this figure, trivalent vanadium is substituted in a Ca site in V-β-TCP and pentavalent vanadium is substituted in a P site in β-TCPV 6 . The lattice parameters of the a-axis and c-axis of V-β-TCPV increased very slightly with increasing vanadium ion content.…”

“…5 Furthermore, the sinterability and good mechanical characteristics of β-TCP doped with vanadium (V) ion (β-TCPV) have also been demonstrated. 6 However, it is known that vanadium ions can be cytotoxic. 7 In this study, a solid-state reaction was carried out to prepare β-TCP doped with a small amount of both V(III) and V(V) ions, and its in vitro cell cytotoxicity was investigated using V79 cells.…”

EFFECT OF VANADIUM ION ADDITION ON SINTERING OF ^|^beta;-TRICALCIUM PHOSPHATE BY HOT PRESSING

“…Tri-and pentavalent vanadium ions were considered to be substituted for a Ca ion at the Ca(5) site located in the A column of the β-TCP crystal structure and for a P ion in the PO 4 group of the β-TCP crystal structure, respectively. 4,5 Compensation of the electric charge of V 3+ and Ca When the specimens were manufactured by hot pressing, relative densities (100 × bulk density/true density) above 95% were achieved. The maximum relative densities of V-β-TCPVs with 0.5 and 1.0 mol% of vanadium ions were 97-99%.…”

“…3 The substitution model and the mechanical characteristics of β-TCP doped with trivalent vanadium ions (V-β-TCP) 4 and β-TCP doped with pentavalent vanadium ions (β-TCPV) have also been demonstrated using normal pressure sintering. 5 The mechanical strength of the obtained sintered body was maximized at a vanadium ion concentration of about 2.5 mol%, and its sinterability was improved by addition of vanadium ions. However, since vanadium ions can be cytotoxic, their concentration needs to be kept low.…”