Mechanical reinforcement of granular hydrogels

Charlet, Alvaro; Bono, F; Amstad, Esther

doi:10.1039/d1sc06231j

Cited by 40 publications

(42 citation statements)

References 91 publications

(155 reference statements)

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“…Commonly used polymers include alginate [ 155 ], silk [ 156 ], gelatin [ 157 ], chitosan [ 158 ], and hyaluronic acid [ 158 , 159 , 160 ]. These biopolymers are typically functionalized with multiple reactive groups covalently attached to their chains, such as acrylates or methacrylates [ 161 ].…”

Section: Preparation Technology Of Macroporous Hydrogelsmentioning

confidence: 99%

Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering

Wang

et al. 2022

Gels

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Hydrogels have been extensively used as scaffolds in tissue engineering for cell adhesion, proliferation, migration, and differentiation because of their high-water content and biocompatibility similarity to the extracellular matrix. However, submicron or nanosized pore networks within hydrogels severely limit cell survival and tissue regeneration. In recent years, the application of macroporous hydrogels in tissue engineering has received considerable attention. The macroporous structure not only facilitates nutrient transportation and metabolite discharge but also provides more space for cell behavior and tissue formation. Several strategies for creating and functionalizing macroporous hydrogels have been reported. This review began with an overview of the advantages and challenges of macroporous hydrogels in the regulation of cellular behavior. In addition, advanced methods for the preparation of macroporous hydrogels to modulate cellular behavior were discussed. Finally, future research in related fields was discussed.

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Section: Preparation Technology Of Macroporous Hydrogelsmentioning

confidence: 99%

Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering

Wang

et al. 2022

Gels

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“…Chemical modification further diversifies the processing and manufacturing techniques that can be used to create 3D HA scaffolds [ 95 , 96 , 97 ]. By easily changing the treatment method, HA hydrogels, granular hydrogels (microgels), electrospinning fibers, and HA-based composites can be formed [ 77 , 98 , 99 , 100 ]. Various types of HA scaffolds have their own characteristics which offer several benefits to CNS regenerative medicine [ 79 ].…”

Section: Therapeutic Relevance Of Ha-based Scaffolds In the Cnsmentioning

confidence: 99%

Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders

Djoudi

Molina-Peña²,

Ferreira³

et al. 2022

IJMS

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Hyaluronic acid (HA) is a Glycosaminoglycan made of disaccharide units containing N-acetyl-D-glucosamine and glucuronic acid. Its molecular mass can reach 10 MDa and its physiological properties depend on its polymeric property, polyelectrolyte feature and viscous nature. HA is a ubiquitous compound found in almost all biological tissues and fluids. So far, HA grades are produced by biotechnology processes, while in the human organism it is a major component of the extracellular matrix (ECM) in brain tissue, synovial fluid, vitreous humor, cartilage and skin. Indeed, HA is capable of forming hydrogels, polymer crosslinked networks that are very hygroscopic. Based on these considerations, we propose an overview of HA-based scaffolds developed for brain cancer treatment, central and peripheral nervous systems, discuss their relevance and identify the most successful developed systems.

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“…However, MAP hydrogels in which the interparticle crosslinks are covalently fixed may face challenges with injectable delivery and self‐healing. [ 12 ] To address these limitations, we have engineered a class of MAP hydrogel based on reversibly interacting polyethylene glycol (PEG) hydrogel microspheres.…”

Section: Introductionmentioning

confidence: 99%

Injectable Microporous Annealed Particle Hydrogel Based on Guest–Host‐Interlinked Polyethylene Glycol Maleimide Microgels

Widener

Duraivel

Angelini

et al. 2022

Advanced NanoBiomed Research

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Microporous annealed particle (MAP) hydrogels have emerged as a versatile biomaterial platform for regenerative medicine. MAP hydrogels have been used for the delivery of cells and organoids but often require annealing post‐injection by an external source. An injectable, self‐annealing MAP hydrogel with reversible interparticle linkages based on guest–host functionalized polyethylene glycol‐maleimide (PEG‐MAL) microgels is engineered. The effect of guest–host linkages is evaluated on different types of microgels fabricated by either batch emulsion or mechanical fragmentation methods. Batch emulsion generates small spherical microgels with controllable (10–100 μm) diameters and mechanical fragmentation generates irregular microgels with larger diameters (100–200 μm). Spherical microgels (15 μm) show self‐healing behavior and have completely recovered from high strain while fragmented microgels (133 μm) do not recover. Guest–host interactions significantly contribute to the mechanical properties of spherical microgels but have no effect on fragmented microgels. Spherical microgels are superior to the fragmented microgels for co‐injection of immune cells and pancreatic islets due to their lower force of injection, demonstrating more homogeneously distributed cells and greater cell viability after injection. Based on these studies, the spherical guest–host MAP hydrogels provide a controllable, injectable scaffold for engineered microenvironments and cell delivery applications.

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Mechanical reinforcement of granular hydrogels

Abstract: Granular hydrogels are composed of hydrogel-based microparticles, so-called microgels, that are densely packed to form an ink that can be 3D printed, injected or cast into macroscopic structures. They are...

Cited by 40 publications

References 91 publications

Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering

Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering

Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders

Injectable Microporous Annealed Particle Hydrogel Based on Guest–Host‐Interlinked Polyethylene Glycol Maleimide Microgels

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