2025
DOI: 10.1152/physiol.00027.2024
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Mechanical Remodeling of Nuclear Biomolecular Condensates

Giulia Soggia,
Yasmin ElMaghloob,
Annie-Kermen Boromangnaeva
et al.

Abstract: Organism health relies on cell proliferation, migration, and differentiation. These universal processes depend on cytoplasmic reorganization driven notably by the cytoskeleton and its force-generating motors. Their activity generates forces that mechanically agitate the cell nucleus and its interior. New evidence from reproductive cell biology revealed that these cytoskeletal forces can be tuned to remodel nuclear membrane-less compartments, known as biomolecular condensates, and regulate their RNA processing … Show more

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