Mechanical responses of the periodontal ligament in the transverse section of the rat mandibular incisor at various velocities of loading in vitro

Chiba, M.; Komatsu, Koichiro

doi:10.1016/0021-9290(93)90017-9

Cited by 69 publications

(52 citation statements)

References 28 publications

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“…On the other hand, nonphysiologic higher magnitudes of TENS provoke proinflammatory signals, which may consequently induce bone resorption, frequently observed at the tension sites in response to a higher magnitude of applied mechanical forces. 4,6,23,29 In both of these processes, molecules of the proinflammatory signal transduction pathways may act as intermediaries for the mechanotransduction pathways to induce synthesis of bone. Whether TENS specifically inhibits IL-1β actions or whether it can counteract actions of other inflammatory mediators like TNF-α, PGE 2 , or endotoxins found in inflamed PDL, has yet to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…In response to applied mechanical forces, osteoblast-like PDL cells perceive mechanical signals and respond to them via cellular events such as cell proliferation, differentiation, matrix catabolism, and matrix synthesis. 6,9,16,24,25 These events, in turn, are controlled by sequential synthesis of cytokines and growth factors that regulate bone resorption at compression sites and bone synthesis at tension sites. 9,14,16,23 It is well documented that compressive forces induce expression of proinflammatory mediators, and interleukin-β (IL-1β) has been implicated as one of the major cytokines synthesized in response to compressive forces exerted on the PDL.…”

Section: Introductionmentioning

confidence: 99%

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Signaling by mechanical strain involves transcriptional regulation of proinflammatory genes in human periodontal ligament cells in vitro

Long

Liu

Piesco

et al. 2002

Bone

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Intracellular signals generated by mechanical strain profoundly affect the metabolic function of osteoblast-like periodontal ligament (PDL) cells, which reside between the tooth and alveolar bone. In response to applied mechanical forces, PDL cells synthesize bone-resorptive cytokines to induce bone resorption at sites exposed to compressive forces and deposit bone at sites exposed to tensile forces in an environment primed for catabolic processes. The intracellular mechanisms that regulate this bone remodeling remain unclear. Here, in an in vitro model system, we show that tensile strain is a critical determinant of PDL-cell metabolic functions. Equibiaxial tensile strain (TENS), when applied at low magnitudes, acts as a potent antagonist of interleukin (IL)-1β actions and suppresses transcriptional regulation of multiple proinflammatory genes. This is evidenced by the fact that TENS at low magnitude: (i) inhibits recombinant human (rh)IL-1β-dependent induction of cyclooxygenase-2 (COX-2) mRNA expression and production of prostaglandin estradiol (PGE 2 ); (ii) inhibits rhIL-1β-dependent induction matrix metalloproteinase-1 (MMP-1) and MMP-3 synthesis by suppressing their mRNA expression; (iii) abrogates rhIL-1β-induced suppression of tissue inhibitor of metalloprotease-II (TIMP-II) expression; and (iv) reverses IL-1β-dependent suppression of osteocalcin and alkaline phosphatase synthesis. Nevertheless, these actions of TENS were observed only in the presence of IL-1β, as TENS alone failed to affect any of the aforementioned responses. The present findings are the first to show that intra-cellular signals generated by low-magnitude mechanical strain interfere with one or more critical step(s) in the signal transduction cascade of rhIL-1β upstream of mRNA expression, while concurrently promoting the expression of osteogenic proteins in PDL cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Signaling by mechanical strain involves transcriptional regulation of proinflammatory genes in human periodontal ligament cells in vitro

Long

Liu

Piesco

et al. 2002

Bone

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“…The short time memory has been described either by extending elastic models (Chiba and Komatsu, 1993;Danto and Woo, 1993) or by superposing spring and dashpot elements (Jamison et al, 1968;Sanjeevi, 1982). With the extension of elastic models, the interpretation of the short time memory depends on the elastic model used, while the addition of spring and dashpot elements is difficult to generalize for large deformations.…”

Section: Introductionmentioning

confidence: 99%

Non-linear viscoelastic laws for soft biological tissues

Pioletti

Rakotomanana

2000

European Journal of Mechanics - A/Solids

154

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-The development of a conceptual framework to test different viscoelastic constitutive laws is presented. This framework has the advantage of satisfying a priori the thermodynamic restrictions and is valid for large deformations. In addition, the different mechanical contributions are separated according to the time scale of their effects. As an illustration of its ability to model the immediate, short time memory and long time memory contributions, the framework is used to identify mechanical tests performed on human patellar tendons. The resulting viscoelastic law is then proposed to model the soft biological tissues as these tissues present an important viscoelastic behaviour.

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“…Few experimental studies have been conducted in this field. Nevertheless, the effect of the strain rate on the stress-strain curves has been demonstrated with anterior cruciate ligament (Kennedy et al, 1976), tendons (Haut, 1983;Sanjeevi, 1982), intrinsic and extrinsic wrist ligament (Nowalk and Logan, 1991), incisor periodontal ligament (Chiba and Komatsu, 1993), and inferior glenohumeral ligament (Ticker et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

“…Extending elastic models (Chiba and Komatsu, 1993;Danto and Woo, 1993) or adding spring and dashpot elements (Jamison et al, 1968;Sanjeevi, 1982) are two popular approaches. With the extension of elastic models, the interpretation of the strain rate effect depends on the elastic model used, while the addition of spring and dashpot elements is difficult to generalize in large deformations.…”

Section: Introductionmentioning

confidence: 99%

Viscoelastic constitutive law in large deformations

Pioletti

Rakotomanana

Benvenuti

et al. 1998

Journal of Biomechanics

237

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Traction tests on soft tissues show that the shape of the stress-strain curves depends on the strain rate at which the tests are performed. Many of the constitutive models that have been proposed fail to properly consider the effect of the strain rate when large deformations are encountered. In the present study, a framework based on elastic and viscous potentials is developed. The resulting constitutive law is valid for large deformations and satisfies the principles of thermodynamics. Three parameters -two for the elasticity and one for the viscosity -were enough to precisely fit the non-linear stress-strain curves obtained at different strain rates with human cruciate ligaments and patellar tendons. The identification results then in a realistic, three-dimensional viscoelastic constitutive law. The developed constitutive law can be used regardless of the strain or rotation values. It can be incorporated into a finite element program to model the viscoelastic behavior of ligaments and tendons under dynamic situations.

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Mechanical responses of the periodontal ligament in the transverse section of the rat mandibular incisor at various velocities of loading in vitro

Cited by 69 publications

References 28 publications

Signaling by mechanical strain involves transcriptional regulation of proinflammatory genes in human periodontal ligament cells in vitro

Signaling by mechanical strain involves transcriptional regulation of proinflammatory genes in human periodontal ligament cells in vitro

Non-linear viscoelastic laws for soft biological tissues

Viscoelastic constitutive law in large deformations

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