Mechanical role of intraluminal thrombus in aneurysm growth: A computational study

Horvat, Nino; Virag, Lana; Karšaj, Igor

doi:10.1007/s10237-021-01478-w

Cited by 9 publications

(5 citation statements)

References 42 publications

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“…Additionally, patients with greater distances between predicted and the literal position of maximum ILT thickness showed a significantly increased PWRI ( Supplementary Table II ). 22 A large movement of the point of the maximum ILT thickness during aneurysm growth might, therefore, be linked to an increase in risk of rupture based on previous similar speculations. 9 , 21 , 23 …”

Section: Discussionmentioning

confidence: 87%

Rupture risk parameters upon biomechanical analysis independently change from vessel geometry during abdominal aortic aneurysm growth

Zschäpitz

Bohmann

Lutz

et al. 2023

JVS-Vascular Science

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Section: Discussionmentioning

confidence: 87%

Rupture risk parameters upon biomechanical analysis independently change from vessel geometry during abdominal aortic aneurysm growth

Zschäpitz

Bohmann

Lutz

et al. 2023

JVS-Vascular Science

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“…Intraluminal thrombus (ILT) resulting from damage to the endothelium in the initial stages of AAA is reported in more than 75% of clinical AAA. ILT is understood to play a protective role in the early stages of aneurysm formation 27 and non‐occlusive ILT correlates with reduced peak wall stress 28 and may lower its rupture potential 29 . The use of anti‐thrombotic therapies in AAA thus continues to be a matter of debate.…”

Section: Resultsmentioning

confidence: 99%

“…ILT is understood to play a protective role in the early stages of aneurysm formation 27 and non-occlusive ILT correlates with reduced peak wall stress 28 and may lower its rupture potential. 29 The use of anti-thrombotic therapies in AAA thus continues to be a matter of debate. It should be noted that our study employed AAA tissue from an advanced stage of the disease characterized by extensive remodeling.…”

Section: Re Sults and Discussionmentioning

confidence: 99%

Structurally abnormal collagen fibrils in abdominal aortic aneurysm resist platelet adhesion

Jones

Debski

Hans

et al. 2022

Journal of Thrombosis and Haemostasis

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Background: Platelet adhesion to the subendothelial collagen fibrils is one of the first steps in hemostasis. Understanding how structural perturbations in the collagen fibril affect platelet adhesion can provide novel insights into disruption of hemostasis in various diseases. We have recently identified the presence of abnormal collagen fibrils with compromised D-periodic banding in the extracellular matrix remodeling present in abdominal aortic aneurysms (AAA).Objective: In this study, we employed multimodal microscopy approaches to characterize how collagen fibril structure impacts platelet adhesion in clinical AAA tissues.Methods: Ultrastructural atomic force microscopy (AFM) analysis was performed on tissue sections after staining with fluorescently labeled collagen hybridizing peptide (CHP) to recognize degraded collagen. Second harmonic generation (SHG) microscopy was used on CHP-stained sections to identify regions of intact versus degraded collagen. Finally, platelet adhesion was identified via SHG and indirect immunofluorescence on the same tissue sections. Results:Our results indicate that ultrastructural features characterizing collagen fibril abnormalities coincide with CHP staining. SHG signal was absent from CHP-positive regions. Additionally, platelet binding was primarily localized to regions with SHG signal. Abnormal collagen fibrils present in AAA (in SHG negative regions) were thus found to inhibit platelet adhesion compared to normal fibrils. Conclusions:Our investigations reveal how the collagen fibril structure in the vessel wall can serve as another regulator of platelet-collagen adhesion. These results can be broadly applied to understand the role of collagen fibril structure in regulating thrombosis or bleeding disorders.

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“…During the development of AAA, there are associated changes in the physiological environment. For instance, the formation and progression of mural thrombus can impact the hemodynamic environment and the material evolution of the vessel wall [38,39] .…”

Section: Discussionmentioning

confidence: 99%

Preliminary establishment and validation of the inversion method for growth and remodeling parameters of patient-specific abdominal aortic aneurysms

Peng,

He,

Luan

et al. 2023

Preprint

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Background Traditional medical imaging studies and biomechanical researches have limitations in analyzing the long-term evolution process of AAA (Abdominal Aortic Aneurysm, AAA). The HCMT (Homogenized Constrained Mixture Theory, HCMT) allows for quantitative analysis of the changes of the three-dimensional morphology and composition of AAA. However, the accuracy of HCMT still requires further clinical verification. Objective This study aims to establish a patient-specific AAA growth model based on HCMT, simulate the long-term G&R (Growth and Remodeling G&R) process of AAA, and validate the feasibility and accuracy of the method using two additional AAA cases with 5 follow-up data. Methods The media and adventitia of the aorta were modeled as mixtures composed of elastin, collagen fibers, and SMC (smooth muscle cells, SMC). The strain energy function was used to describe the continuously generation and degradation of the mixture during the AAA G&R process. Multiple sets of growth parameters were applied to finite element simulations, and the simulation results were compared with the follow-up data for gradually selecting the optimal growth parameters. Two additional AAA patients with different growth rates were used for validating the method, the optimal growth parameters were obtained using the first two follow-up imaging data, and the growth model was applied to simulate the subsequent four time points. The differences between the simulated diameters and the follow-up diameters of AAA were compared to validate the accuracy of the growth model. Results The growth parameters, especially the stress-mediated substance deposition gain factor Kσi, is highly related to the AAA G&R process. When setting the optimal growth parameters to simulate AAA growth, the proportion of simulation results within the distance of less than 0.5 mm from the follow-up model is above 80%. For the validating cases, during the 5 follow-up processes, the mean difference rates between the simulated diameter and the real-world diameter are within 2.5%, which basically meets the clinical demand for quantitatively predicting the AAA growth in maximum diameters. Conclusion This study simulated the growth process of AAA, and validated the accuracy of this growth model. This method was proved to be used to predict the G&R process of AAA caused by dynamic changes in the mixtures of the AAA vessel wall at a long-term time scale, assisting accurately and quantitatively predicting the multi-dimensional morphological development and mixtures evolution process of AAA in clinic.

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Mechanical role of intraluminal thrombus in aneurysm growth: A computational study

Cited by 9 publications

References 42 publications

Rupture risk parameters upon biomechanical analysis independently change from vessel geometry during abdominal aortic aneurysm growth

Rupture risk parameters upon biomechanical analysis independently change from vessel geometry during abdominal aortic aneurysm growth

Structurally abnormal collagen fibrils in abdominal aortic aneurysm resist platelet adhesion

Preliminary establishment and validation of the inversion method for growth and remodeling parameters of patient-specific abdominal aortic aneurysms

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