Durable concrete significantly reduces the spalling caused by chemical damage. The objective of current research is to substitute cement with supplementary such as fly ash (FA), ground granulated blast furnace slag (GGBS), and alccofine (AF). Additionally, the impact of nano-silica (NS) and silica fumes (SF) on the GPC durability when cured at various temperatures has been attempted. In order to perform this, GPC samples were produced by combining NS and SF at proportions of 0.5% NS + 5% SF, 1% NS + 10% SF, and 1.5% NS + 15% SF, and then cured at temperatures of 27 °C, 60 °C, 90 °C, and 120 °C, respectively. In this research, all concrete specimens were continuously immersed for twelve weeks under four different chemicals, i.e., HCl (2%), H2SO4 (2%), NaCl (6%), and Na2SO4 (6%). The influence of chemical attack on the qualities of concrete was examined by evaluating the water absorption, sorptivity, loss of mass, and loss of GPC strength. The durability aspect is also studied by visual appearance and mass loss under harmful chemical attack. The combination of GPC with integrated NS and SF affords great resistance against chemical attacks. The percentages of these two components are 1.5% and 15%. For GPC specimens, when cured at 90 °C, the resultant strength is found at its maximum.