2004
DOI: 10.1016/j.exphem.2004.08.011
|View full text |Cite
|
Sign up to set email alerts
|

Mechanical stress promotes the expression of smooth muscle-like properties in marrow stromal cells

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

3
73
2

Year Published

2006
2006
2021
2021

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 101 publications
(78 citation statements)
references
References 43 publications
3
73
2
Order By: Relevance
“…Furthermore, MSCs that have been exposed to high shear stress show a significantly higher expression of SMC markers (myocardin, SMMHC and SM22α) . By contrast, other studies have suggested that shear stress increases the amount of TGF-β1 and of SMC markers (Park et al, 2007;Kobayashi et al, 2004). These apparent inconsistencies regarding the expression of TGF-β1 and SMC-specific markers could be attributable to the use of different types of stem cells, culture conditions or shear stress regimes.…”
Section: Inhibition Of Smc Differentiationcontrasting
confidence: 38%
“…Furthermore, MSCs that have been exposed to high shear stress show a significantly higher expression of SMC markers (myocardin, SMMHC and SM22α) . By contrast, other studies have suggested that shear stress increases the amount of TGF-β1 and of SMC markers (Park et al, 2007;Kobayashi et al, 2004). These apparent inconsistencies regarding the expression of TGF-β1 and SMC-specific markers could be attributable to the use of different types of stem cells, culture conditions or shear stress regimes.…”
Section: Inhibition Of Smc Differentiationcontrasting
confidence: 38%
“…O'Cearbhaill et al [29] did not observe vWF expression on the protein level under static or mechanically stimulated conditions, nor did they observe a significant change in vWF at the mRNA level. The combined effect of radial stress and hoop stress used in the experiment may have surpassed the effect of shear stress in cell differentiation, because cyclic stress promotes the expression of smooth muscle-like properties [10,30,31] . Because MSCs can also differentiate along SMC lines, we hypothesized that differentiation along the endothelial line might accompany shear stress-induced negative regula- tion of the expression of SMC-related markers, such as SM α-actin and calponin.…”
Section: Discussionmentioning
confidence: 99%
“…Local environment and resident cellular populations are likely to be crucial factors in determining their differentiation fates (Minguell et al, 2001;Caplan, 1991). In vitro, bone marrowderived MSCs have been shown to differentiate to smooth muscle cells (SMCs) in response to transforming growth factor ␤ (TGF-␤) (Kinner et al, 2002;, mechanical stress (Kobayashi et al, 2004) and direct contact with vascular endothelial cells (Ball et al, 2004). In vivo, injected bone marrow-derived MSCs are able to differentiate into SMCs and contribute to the remodeling of vasculature (Davani et al, 2003;Yoon et al, 2005;Gojo et al, 2003).…”
Section: Introductionmentioning
confidence: 99%