Mechanical stretch enhances the expression and activity of osteopontin and MMP-2 via the Akt1/AP-1 pathways in VSMC

Seo, Kyo Won; Lee, Seung Jin; Ye, Byeong Hyeok; Kim, Young Whan; Bae, Sun Sik; Kim, Chi Dae

doi:10.1016/j.yjmcc.2015.05.006

Cited by 44 publications

(34 citation statements)

References 38 publications

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“…Experimental studies performed in various animal models and humans suggest that osteopontin plays a pivotal role in the development of atherosclerosis, vascular remodeling, and restenosis [18,19,20]. Osteopontin has been shown to be an important contributor to the migration of vascular smooth muscle cells through degradation of extracellular matrix in animal studies using angiotensin II-induced hypertension models [21].…”

Section: Discussionmentioning

confidence: 99%

Urinary Osteopontin Predicts Incident Chronic Kidney Disease, while Plasma Osteopontin Predicts Cardiovascular Death in Elderly Men

Feldreich

Carlsson

Helmersson‐Karlqvist³

et al. 2017

Cardiorenal Med

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Background and Objectives: The matricellular protein osteopontin is involved in the pathogenesis of both kidney and cardiovascular disease. However, whether circulating and urinary osteopontin levels are associated with the risk of these diseases is less studied. Design, Setting, Participants, and Measurements: A community-based cohort of elderly men (Uppsala Longitudinal Study of Adult Men [ULSAM]; n = 741; mean age: 77 years) was used to study the associations between plasma and urinary osteopontin, incident chronic kidney disease, and the risk of cardiovascular death during a median of 8 years of follow-up. Results: There was no significant cross-sectional correlation between plasma and urinary osteopontin (Spearman ρ = 0.07, p = 0.13). Higher urinary osteopontin, but not plasma osteopontin, was associated with incident chronic kidney disease in multivariable models adjusted for age, cardiovascular risk factors, baseline glomerular filtration rate, urinary albumin/creatinine ratio, and the inflammatory markers interleukin 6 and high-sensitivity C-reactive protein (odds ratio for 1 standard deviation [SD] of urinary osteopontin, 1.42, 95% CI 1.00-2.02, p = 0.048). Conversely, plasma osteopontin, but not urinary osteopontin, was independently associated with cardiovascular death (multivariable hazard ratio per SD increase, 1.35, 95% CI 1.14-1.58, p < 0.001, and 1.00, 95% CI 0.79-1.26, p = 0.99, respectively). The addition of plasma osteopontin to a model with established cardiovascular risk factors significantly increased the C-statistics for the prediction of cardiovascular death (p < 0.002). Conclusions: Higher urinary osteopontin specifically predicts incident chronic kidney disease, while plasma osteopontin specifically predicts cardiovascular death. Our data put forward osteopontin as an important factor in the detrimental interplay between the kidney and the cardiovascular system. The clinical implications, and why plasma and urinary osteopontin mirror different pathologies, remain to be established.

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Section: Discussionmentioning

confidence: 99%

Urinary Osteopontin Predicts Incident Chronic Kidney Disease, while Plasma Osteopontin Predicts Cardiovascular Death in Elderly Men

Feldreich

Carlsson

Helmersson‐Karlqvist³

et al. 2017

Cardiorenal Med

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“…Osteopontin (OPN), an ECM glycoprotein, plays an important role in vascular disease and in response to vascular injury by stimulating VSMC migration, proliferation, and ECM synthesis. The Journal of Molecular and Cellular Cardiology has recently published the work by Seo et al 'Mechanical stretch enhances the expression and activity of osteopontin and MMP-2 via the Akt1/AP-1 pathways in VSMC', which studied the role of OPN in VSMCs in an in vitro model of mechanical stretch and in vivo models of hypertension [8].Seo and colleagues showed that plasma and aortic levels of OPN are 1.2-3-fold elevated in hypertensive rats and mice and positively correlated with systolic blood pressure (p b 0.01), revealing that OPN may be a useful biomarker of hypertension-induced vascular remodeling. Using an elegant set of pharmacological inhibitors and knockdown approaches, the authors identified phosphatidylinositol 3-kinase (PI3K)/Akt1 through the AP-1 promoter as the major signaling pathway responsible for VSMC mechanical stretch-mediated OPN overexpression [8].…”

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Osteopontin: A major player on hypertension-induced vascular remodeling

Brás

2015

Journal of Molecular and Cellular Cardiology

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“…Which will causes the phosphorylation of tau and the production of amyloid (Lynch and Daly, 2002;Pan et al, 2010). And some results suggested that OPN expression in the hypertensive vasculature was increased via signaling pathways that involve Akt1/AP-1, leading to vascular remodeling by increasing the production of MMP-2 (Seo et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

Study on the Anti-hypertension mechanism of Prunella Vulgaris based on entity grammar systems

Du¹,

Li²,

Zhang³

et al. 2015

TANG [HUMANITAS MEDICINE]

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Literatures and experimental studies have shown that Prunella has an effect on anti-hypertension, however, its components are complicated, so that it is still difficult to clear the specific roles of its various components in blood pressure regulation in. So we decide to systematically study the anti-hypertension mechanism of Prunella. We integrated multiple databases and constructed molecular interaction network between the chemical constituents of Prunella Vulgaris and hypertension based on entity grammar systems model. The network has 262 nodes and 802 edges. Then we infer the interactions between chemical compositions and disease targets to clarify the anti-hypertension mechanism. Finally, we found Prunella could influence hypertension by regulating apoptosis, cell proliferation, blood vessel development and vasoconstriction, etc. Thus this study provides reference for drug development and compatibility, and also gives guidance for health care at a certain extent.

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Mechanical stretch enhances the expression and activity of osteopontin and MMP-2 via the Akt1/AP-1 pathways in VSMC

Cited by 44 publications

References 38 publications

Urinary Osteopontin Predicts Incident Chronic Kidney Disease, while Plasma Osteopontin Predicts Cardiovascular Death in Elderly Men

Urinary Osteopontin Predicts Incident Chronic Kidney Disease, while Plasma Osteopontin Predicts Cardiovascular Death in Elderly Men

Osteopontin: A major player on hypertension-induced vascular remodeling

Study on the Anti-hypertension mechanism of Prunella Vulgaris based on entity grammar systems

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