Mechanical testing of antimicrobial biocomposite coating on metallic medical implants as drug delivery system

Karacan, Ipek; Ben‐Nissan, Besim; Wang, Hang Andy; Juritza, A.; Swain, Michael V.; Müller, Wolfgang; Chou, Joshua; Stamboulis, Artemis; Macha, Innocent J.; Taraschi, Valerio

doi:10.1016/j.msec.2019.109757

Cited by 32 publications

(21 citation statements)

References 30 publications

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“…Nano-textured Ti surfaces coated with calcium phosphate and functionalized with antimicrobial peptides exhibited anti-biofilm and anti-fouling potential against Escherichia coli and Streptococcus mutans bacteria [ 120 ]. HAp-based coatings loaded with Gentamicin showed significant inhibitory effects against Staphylococcus aureus [ 121 , 122 ] and Escherichia coli [ 123 ]. Composite coatings of HAp and poly(lactide-co-glycolide) loaded with Ceftriaxone and Cefuroxime antibiotics significantly impaired Ti substrates’ contamination and colonization with Escherichia coli [ 124 ].…”

Section: Resultsmentioning

confidence: 99%

Bioactive Coatings Based on Hydroxyapatite, Kanamycin, and Growth Factor for Biofilm Modulation

Gherasim

Grumezescu

et al. 2021

Antibiotics

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The occurrence of opportunistic local infections and improper integration of metallic implants results in severe health conditions. Protective and tunable coatings represent an attractive and challenging selection for improving the metallic devices’ biofunctional performances to restore or replace bone tissue. Composite materials based on hydroxyapatite (HAp), Kanamycin (KAN), and fibroblast growth factor 2 (FGF2) are herein proposed as multifunctional coatings for hard tissue implants. The superior cytocompatibility of the obtained composite coatings was evidenced by performing proliferation and morphological assays on osteoblast cell cultures. The addition of FGF2 proved beneficial concerning the metabolic activity, adhesion, and spreading of cells. The KAN-embedded coatings exhibited significant inhibitory effects against bacterial biofilm development for at least two days, the results being superior in the case of Gram-positive pathogens. HAp-based coatings embedded with KAN and FGF2 protein are proposed as multifunctional materials with superior osseointegration potential and the ability to reduce device-associated infections.

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Section: Resultsmentioning

confidence: 99%

Bioactive Coatings Based on Hydroxyapatite, Kanamycin, and Growth Factor for Biofilm Modulation

Gherasim

Grumezescu

et al. 2021

Antibiotics

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“…The implant surface provides a medium for bacterial adhesion by forming a physical defensive biofilm and diminishes the systemic antibiotic diffusion, resulting in relatively limited drug availability at the infection site [230]. Therefore, scientists are constantly making efforts to develop and optimize antibiotic-loaded therapeutic coatings for dental implants to treat chronic peri-implant infections [164,231,232]. Several therapeutic modifications of implant coatings treating localized implant-bone infections have been proposed by incorporating antibiotics, antimicrobial peptides, and disinfectants.…”

Section: Antibacterial Coatingsmentioning

confidence: 99%

“…A number of studies [58,228,231,[234][235][236] have investigated the incorporation of antimicrobial agents to the implants' coating using dip or spray coating methods. However, it is very challenging to meet the desired requirements during production of implant coatings.…”

Section: Antibacterial Coatingsmentioning

confidence: 99%

“…An in vitro study investigated titania nanotubes loaded with gentamicin and reported therapeutic release of the drug, reduction in bacterial adhesion, and enhanced osteoblastic activity [238]. Elution of therapeutic drugs significantly reduced the bacterial adhesion and enhanced osteoblastic differentiation [191,231,239]. Similarly, tetracycline coatings enhanced the attachment and retention of blood clots on the surface during an earlier phase of healing, thereby promoting osseointegration [58].…”

Section: Antibacterial Coatingsmentioning

confidence: 99%

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Customized Therapeutic Surface Coatings for Dental Implants

et al. 2020

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Dental implants are frequently used to support fixed or removable dental prostheses to replace missing teeth. The clinical success of titanium dental implants is owed to the exceptional biocompatibility and osseointegration with the bone. Therefore, the enhanced therapeutic effectiveness of dental implants had always been preferred. Several concepts for implant coating and local drug delivery had been developed during the last decades. A drug is generally released by diffusion-controlled, solvent-controlled, and chemical controlled methods. Although a range of surface modifications and coatings (antimicrobial, bioactive, therapeutic drugs) have been explored for dental implants, it is still a long way from designing sophisticated therapeutic implant surfaces to achieve the specific needs of dental patients. The present article reviews various interdisciplinary aspects of surface coatings on dental implants from the perspectives of biomaterials, coatings, drug release, and related therapeutic effects. Additionally, the various types of implant coatings, localized drug release from coatings, and how released agents influence the bone–implant surface interface characteristics are discussed. This paper also highlights several strategies for local drug delivery and their limitations in dental implant coatings as some of these concepts are yet to be applied in clinical settings due to the specific requirements of individual patients.

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“…For example, slow drug delivery systems based on biodegradable poly-lactic acid and antibiotic loaded hydroxyapatite microspheres were developed to be applied as coating on metal implants to prevent post-operative infections [ 25 ]. Chang et al [ 26 ] prepared biodegradable corn starch films and used a PLA coating to improve theirwaterproof performance.…”

Section: Introductionmentioning

confidence: 99%

Modification of PLA-Based Films by Grafting or Coating

Miletić

Ristić

Coltelli

et al. 2020

JFB

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Recently, the demand for the use of natural polymers in the cosmetic, biomedical, and sanitary sectors has been increasing. In order to meet specific functional properties of the products, usually, the incorporation of the active component is required. One of the main problems is enabling compatibility between hydrophobic and hydrophilic surfaces. Therefore, surface modification is necessary. Poly(lactide) (PLA) is a natural polymer that has attracted a lot ofattention in recent years. It is bio-based, can be produced from carbohydrate sources like corn, and it is biodegradable. The main goal of this work was the functionalization of PLA, inserting antiseptic and anti-inflammatory nanostructured systems based on chitin nanofibrils–nanolignin complexes ready to be used in the biomedical, cosmetics, and sanitary sectors. The specific challenge of this investigation was to increase the interaction between the hydrophobic PLA matrix with hydrophilic chitin–lignin nanoparticle complexes. First, chemical modification via the “grafting from” method using lactide oligomers was performed. Then, active coatings with modified and unmodified chitin–lignin nanoparticle complexes were prepared and applied on extruded PLA-based sheets. The chemical, thermal, and mechanical characterization of prepared samples was carried out and the obtained results were discussed.

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Mechanical testing of antimicrobial biocomposite coating on metallic medical implants as drug delivery system

Cited by 32 publications

References 30 publications

Bioactive Coatings Based on Hydroxyapatite, Kanamycin, and Growth Factor for Biofilm Modulation

Bioactive Coatings Based on Hydroxyapatite, Kanamycin, and Growth Factor for Biofilm Modulation

Customized Therapeutic Surface Coatings for Dental Implants

Modification of PLA-Based Films by Grafting or Coating

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