Mechanical testing of cryopreserved aortic allografts

Veselý, Ivan; Gonzalez‐Lavin, Lorenzo; Graf, Debra; Boughner, Derek R.

doi:10.1016/s0022-5223(19)35641-7

Cited by 39 publications

(6 citation statements)

References 14 publications

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“…The antigenicity of the blood vessel exists in the endothelial cells which are the first point of contact between the recipient and the donor tissue and the first to be recognized by the immune system (16,17). It has been reported that certain parts of the MHC antigenic determinant may be blocked by lyophilization treatment, reducing immunogenicity (18). A murine grafting study revealed that the levels of MHC I and MHC II antigens decreased by 70% following lyophilization (19).…”

Section: Discussionmentioning

confidence: 99%

The effect of vacuum freeze-drying and radiation on allogeneic aorta grafts

Cao

Liu

et al. 2012

Molecular Medicine Reports

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Vacuum freeze-dried aorta is a satisfactory material for blood vessel grafting. Previous studies have focused on immunity, however, vacuum freeze-drying is a complicated process of heat and mass transfer, and adopting a programmed cooling process may more completely preserve the mechanical properties of the blood vessels. Irradiation, as a method of removing pathogens, lowers the antigenic activity of the blood vessels. In our study, vacuum freeze-drying combined with radiation was used as a treatment for porcine aorta prior to grafting, aimed at deactivating endogenous retrovirus, shielding masses of endothelial cells and lowering the immunogenicity of the blood vessels. As for the mechanical properties, compared with normal aorta, the maximum axial tensile stress (ATS) decreased by 20%, the maximum circumferential tensile stress (CTS) increased by 30% and the maximum puncture stress (PT) decreased by 20%. Our results revealed that 2 months after of grafting, the host cells had migrated into the graft tissue and propagated to initiate endothelialization, the inflammatory reaction was abated and the PT had returned to normal levels.

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Section: Discussionmentioning

confidence: 99%

The effect of vacuum freeze-drying and radiation on allogeneic aorta grafts

Cao

Liu

et al. 2012

Molecular Medicine Reports

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“…By the mid-1980s, cryopreserved homograft valves were considered by many surgeons to be the valve conduit of choice for replacement of the pulmonary valve, because they seemed to have many advantages over alternative prosthetic valved conduits. 2,[5][6][7][12][13][14][15]20,21 These advantages include (1) technical ease of implantation because they are soft and mold easily with the patient's cardiac tissue, 22 resulting in better hemostasis in complex operations 21,23 ; (2) better hemodynamics than porcine-valved Dacron conduits, which improves right ventricular function after the operation 5,7,21,[23][24][25] ; and (3) the branches of the homografts may be used to patch distal pulmonary artery stenoses. 7,20,26 As the Ross operation (pulmonary autograft replacement of the aortic valve) has gained popularity, so too has the use of the pulmonary homograft to reconstruct the RVOT in this patient population.…”

Section: Discussionmentioning

confidence: 99%

Cryopreserved homograft valves in the pulmonary position: Risk analysis for intermediate-term failure

Niwaya

Knott‐Craig

Lane

et al. 1999

The Journal of Thoracic and Cardiovascular Surgery

143

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“…16 Despite the success obtained with these methods, some researchers have reported the superiority of autograft and homograft valve replacement for complex aortic valve endocarditis. [3][4][5][6] Aortic homografts and autografts (Ross procedures) have been used for infectious endocarditis because these grafts mold well to the fragile infected aortic anulus, 3,17 offer excellent hemodynamic performance, 18 and are resistant to infection. Aortic homografts offer an attractive alternative to the implantation of prosthetic material.…”

Section: Brief Communicationsmentioning

confidence: 99%

Aortic root replacement with Freestyle stentless valve for complex aortic root infection

Fukui

Suehiro

Shibata

et al. 2003

The Journal of Thoracic and Cardiovascular Surgery

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ortic valve replacement in the presence of infectious endocarditis with an aortic annular abscess, aortic root destruction, and left ventricular-aortic discontinuity, remains a formidable surgical challenge. Early diagnosis and surgical intervention can be lifesaving. [1][2][3] Radical de´bridement of infected tissues and reconstruction of the left ventricular outflow tract are fundamental tenets of treatment. However, the choice of valve substitute remains one of the most contentious subjects in the management of this condition. Although several researchers 3-6 have reported success with homografts and autografts, prosthetic valve replacement remains the standard surgical approach. [7][8][9] Recently the porcine stentless bioprosthesis has gained favor as an aortic valve replacement because its hemodynamic performance is excellent and it has good midterm durability. [10][11][12] We have used this prosthesis in 5 patients with complex aortic root infection during the past 3 years, and that experience is the basis of this report.

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Mechanical testing of cryopreserved aortic allografts

Cited by 39 publications

References 14 publications

The effect of vacuum freeze-drying and radiation on allogeneic aorta grafts

The effect of vacuum freeze-drying and radiation on allogeneic aorta grafts

Cryopreserved homograft valves in the pulmonary position: Risk analysis for intermediate-term failure

Aortic root replacement with Freestyle stentless valve for complex aortic root infection

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