Mechanical Thrombectomy in Pulmonary Embolism Associated with COVID-19: A “Clotography” Gallery

Balanescu, Dinu Valentin; Kado, Herman; Mertens, Amy; Chand, Rajat; Savin, Michael A.; McNally, Vicki; Bowers, Thomas A.

doi:10.1177/15385744211037600

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…In contrast to arterial thrombotic events, venous thrombotic events are a more common sequela of COVID-19, with the PE and DVT at an estimated incidence of 13.5% and 11.8% respectively[ 16 ].In our study, PE accounted for 10% ( n = 7) of thrombotic events necessitating surgical intervention[ 33 - 36 ], notably higher than both the reported incidence of PE amongst non-intensive care unit (ICU) hospitalized patients and ICU patients with COVID-19 (1.3% and 6.2%, respectively)[ 37 , 38 ]. Interestingly, our study included two cases of phlegmasia cerulean dolens (PCD)[ 39 , 40 ], a rare and life-threatening form of DVT that results in arterial occlusion secondary to compartment syndrome caused by total venous occlusion[ 41 ].…”

Section: Discussionmentioning

confidence: 94%

Associations between SARS-CoV-2 infections and thrombotic complications necessitating surgical intervention: A systematic review

Ferraro¹,

Reynolds²,

Edoigiawerie³

et al. 2022

World J Methodol

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BACKGROUND Several unique clinical features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19) infection, have been identified and characterized. One such feature, mostly among patients with severe COVID-19 infection, has become known as COVID-19-induced coagulopathy. Surgical patients with a history of or active COVID-19 infection bear a significantly higher risk for postoperative thrombotic complications. These patients may require surgical intervention to treat severe thrombotic complications. Few studies have been carried out to better characterize this association. The purpose of this study was to perform a systematic review and meta-analysis of the literature on COVID-19 infections that led to thrombotic complications necessitating surgical intervention. We hypothesized that patients with recent or active COVID-19 infection would have high rates of thromboembolic complications both arterial and venous in origin. AIM To perform a systematic review and meta-analysis of the literature on COVID-19 infections that led to thrombotic complications necessitating surgical intervention. METHODS The current systematic review implemented an algorithmic approach to review all the currently available English medical literature on surgical interventions necessitated by COVID-19 thrombotic complications using the preferred reporting items for systematic reviews and meta-analysis principles. A comprehensive search of the medical literature in the “PubMed”, “Scopus”, “Google Scholar” top 100 results, and archives of Plastic and Reconstructive Surgery was performed using the key words “COVID-19” AND “surgery” AND “thromboembolism” AND “complication”. The search string was generated and the records which were not specific about surgical interventions or thrombotic complications due to COVID-19 infection were excluded. Titles and abstracts were screened by two authors and full-text articles were assessed for eligibility and inclusion. Finally, results were further refined to focus on articles that focused on surgical interventions that were necessitated by COVID-19 thrombotic complications. RESULTS The database search resulted in the final inclusion of 22 retrospective studies, after application of the inclusion/exclusion criteria. Of the included studies, 17 were single case reports, 3 were case series and 2 were cross sectional cohort studies. All studies were retrospective in nature. Twelve of the reported studies were conducted in the United States of America, with the remaining studies originating from Italy, Turkey, Pakistan, France, Serbia, and Germany. All cases reported in our study were laboratory confirmed SARS-CoV-2 positive. A total of 70 cases involving surgical intervention were isolated from the 22 studies included in this review. CONCLUSION There is paucity of data describing the relationship...

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Section: Discussionmentioning

confidence: 94%

Associations between SARS-CoV-2 infections and thrombotic complications necessitating surgical intervention: A systematic review

Ferraro¹,

Reynolds²,

Edoigiawerie³

et al. 2022

World J Methodol

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“…So, this isolated laboratory marker does not guarantee a worse prognosis in patients with COVID-19, in order to change the workup, more detail is needed with other more specific tests. 18,19 Hematological manifestations, such as thrombocytopenia, lymphopenia and eosinopenia, have prognostic significance in the context of COVID-19, however, few data are available on the prevalence and importance in cases of COVID-19. hematological tests to define their carriers as more susceptible to worse outcomes when infected with SARS-CoV-2.…”

Section: Discussionmentioning

confidence: 99%

COVID-19: epidemiological data of 1263 patients from southern Minas Gerais, Brazil

Romero

Pelizzaro

Filho

et al. 2022

Int J Community Med Public Health

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Background: COVID-19 is an easily contagious and high-speed viral disease that is directly affecting people's lives and exposing the fragility of health systems around the world, especially in Brazil. In this context, the present research sought to observe, through medical records, the conduct of positive patients with COVID-19.Methods: The methodology used was the analysis of medical records of patients with COVID-19 in five hospitals in Minas Gerais. The following data were collected from patients who were hospitalized from March 2020 to October 2020: personal characteristics; pathological antecedents and evolution of the clinical picture.Results: The results found describe the number of patients in each of the analysed hospitals. In addition, the predominant age, the sex of the patients in percentage, the number of patients with subarachnoid hemorrhage (SAH), chronic obstructive pulmonary disease (COPD), diabetes, dyslipidemia, altered D-dimer, anemia and hematologic change are described. Intensive care unit (ICU) and ward admissions are also addressed, as well as the type of respiratory complication, percentage of individuals who required intubation, intubation time and outcome. The results were used in statistical analysis for the association between variables with the Chi-square test to verify the significance between them. The outcome was compared with age, sex, diabetes, dyslipidemia, D-dimer biomarker, anemia, hematological changes and type of hospitalization. With the type of hospitalization, diabetes and dyslipidemia were compared.Conclusions: Faced with all this context of public health urgency, this work helps in the standardization of variables to collaborate in the fight against this giant and persistent virus that public health is trying to fight.

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“…45 The high-risk population subset in FLASH also has been evaluated and demonstrated positive outcomes, with zero mortalities seen in the 63 high-risk patients at 48 hours and significant reduction in RV/LV ratio from 1.5 at baseline to 1.1 at 48 hours and 0.9 at 30 days. 47 Analysis of a subset of FLASH patients in whom intravascular ultrasound was used pre-and post-thrombectomy 48 as well as several non-industry single-center studies of FlowTriever have also been published, including single-center and multicenter evaluations, [49][50][51][52][53] showing comparable safety and effectiveness outcomes as demonstrated by the FLASH registry data. Table 2 summarizes the risks and benefits of PE treatments discussed in this review.…”

Section: Mechanical Thrombectomymentioning

confidence: 99%

Catheter Interventions for Pulmonary Embolism: Mechanical Thrombectomy Versus Thrombolytics

Mouawad

2024

Methodist DeBakey Cardiovascular Journal

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Pulmonary embolism is a debilitating and potentially life-threatening disease characterized by high mortality and long-term adverse outcomes. Traditional treatment options are fraught with serious bleeding risks and incomplete thrombus removal, necessitating the development of innovative treatment strategies. While new interventional approaches offer promising potential for improved outcomes with fewer serious complications, their rapid development and need for more comparative clinical evidence makes it challenging for physicians to select the optimal treatment for each patient among the many options. This review summarizes the current published clinical data for both traditional treatments and more recent interventional approaches indicated for pulmonary embolism. While published studies thus far suggest that these newer interventional devices offer safe and effective options, more data is needed to understand their impact relative to the standard of care. The studies in progress that are anticipated to provide needed evidence are reviewed here since they will be critical for helping physicians make informed treatment choices and potentially driving necessary guideline changes.

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Mechanical Thrombectomy in Pulmonary Embolism Associated with COVID-19: A “Clotography” Gallery

Cited by 3 publications

References 4 publications

Associations between SARS-CoV-2 infections and thrombotic complications necessitating surgical intervention: A systematic review

Associations between SARS-CoV-2 infections and thrombotic complications necessitating surgical intervention: A systematic review

COVID-19: epidemiological data of 1263 patients from southern Minas Gerais, Brazil

Catheter Interventions for Pulmonary Embolism: Mechanical Thrombectomy Versus Thrombolytics

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