Mechanical Ventilation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Retrospective Observational Study

Pesaro, Antônio Eduardo Pereira; Katz, Marcelo; Katz, Jason N.; Barbas, Carmen Sílvia Valente; Makdisse, Márcia; Correa, AG; Franken, Marcelo; Pereira, Carolina; Serrano, Carlos; Lópes, Renato D.

doi:10.1371/journal.pone.0151302

Cited by 15 publications

(6 citation statements)

References 23 publications

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“…Previous studies have indicated that about 8% of patients with AMI required mechanical ventilation, and 3-4% of patients were treated with hemodialysis or other forms of renal replacement therapy [34, 35]. And the use of these interventions has been proved to be significantly associated with the poor survival of patients [35, 36], which is the same as our results.…”

Section: Discussionsupporting

confidence: 89%

Development and validation of nomogram to predict long-term prognosis of critically ill patients with acute myocardial infarction

Tang

Zha

Zeng

et al. 2020

Preprint

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Background: Acute myocardial infarction (AMI) is a common critical illness in the cardiovascular field, with poor prognosis. This study aimed to construct a nomogram to predict long-term survival of critically ill patients with AMI, which helps to assess severity, guide treatment, and improve prognosis. Methods and results: The clinical data of patients with AMI was extracted from the database MIMIC-III v1.4. The Cox proportional hazards models were performed to identify the independently prognostic factors, and a nomogram for predicting long-term survival of AMI patients was developed based on the multifactor analysis, of which discriminative ability and accuracy was evaluated by concordance index (C-index) and calibration curve. Results: A total of 1202 patients were included in the analysis, of which 841 were divided into the training set and 361 were the validation. Multivariate analysis shown that age, blood urea nitrogen, respiratory rate, SAPSII score, cardiogenic shock, cardiac arrhythmias, and respiratory failure served as the independently predictive factors, which were incorporated into the nomogram. Moreover, the nomogram shown favorable performance for predicting 4-year survival of AMI patients with the C- index of 0.788 [95% confidence interval (CI): 0.763 to 0.813] and 0.783 (95% CI: 0.748 to 0.818) in the training and validation set, respectively. Conclusion: The nomogram we constructed here can accurately predict the long-term survival of patients with AMI.

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Section: Discussionsupporting

confidence: 89%

Development and validation of nomogram to predict long-term prognosis of critically ill patients with acute myocardial infarction

Tang

Zha

Zeng

et al. 2020

Preprint

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show abstract

“…Approximately 8% of patients with AMI require mechanical ventilation, and 3-4% of are treated with hemodialysis or other forms of renal replacement therapy. 33,34 The use of these interventions has been proved to be strongly associated with the poor survival of patients, 35 a finding similar to our results.…”

Section: Dovepresssupporting

confidence: 91%

Development and Validation of Nomogram to Predict Long-Term Prognosis of Critically Ill Patients with Acute Myocardial Infarction

Tang¹,

Chen²,

Zha³

et al. 2021

IJGM

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Purpose: Acute myocardial infarction (AMI) is a common cardiovascular disease with a poor prognosis. The aim of this study was to construct a nomogram for predicting the longterm survival of critically ill patients with AMI. This nomogram will help in assessing disease severity, guiding treatment, and improving prognosis. Patients and Methods: The clinical data of patients with AMI were extracted from the MIMIC-III v1.4 database. Cox proportional hazards models were adopted to identify independent prognostic factors. A nomogram for predicting the long-term survival of these patients was developed on the basis of the results of multifactor analysis. The discriminative ability and accuracy of the multifactor analysis were evaluated according to concordance index (C-index) and calibration curves. Results: A total of 1202 patients were included in the analysis. The patients were randomly divided into a training set (n = 841) and a validation set (n = 361). Multivariate analysis revealed that age, blood urea nitrogen, respiratory rate, hemoglobin, pneumonia, cardiogenic shock, dialysis, and mechanical ventilation, all of which were incorporated into the nomogram, were independent predictive factors of AMI. Moreover, the nomogram exhibited favorable performance in predicting the 4-year survival of patients with AMI. The training set and the validation set had a C-index of 0.789 (95% confidence interval [CI]: 0.765-0.813) and 0.762 (95% CI: 0.725-0.799), respectively. Conclusion:The nomogram constructed herein can accurately predict the long-term survival of critically ill patients with AMI.

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“…Regarding hemodynamics, PCWP is usually higher than 15mm Hg, which leads to increased left ventricular lling pressure. Hence, CS patients are often associated with severe pulmonary edema (5,13).…”

Section: Discussionmentioning

confidence: 99%

Effect of Early Protective Lung Ventilation on Mortality and Hemodynamics in Patients With Acute Myocardial Infarction Complicated With Cardiogenic Shock and Pulmonary Edema Undergoing Emergency Interventional Therapy

Yang

Han

Guo

et al. 2021

Preprint

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Background: To investigate the effect of early protective lung ventilation (EPLV) on mortality and hemodynamic parameters in patients with acute myocardial infarction complicated with cardiogenic shock (CS) and pulmonary edema undergoing emergency percutaneous coronary intervention (PCI).Methods: From January 2015 to June 2017, patients with acute myocardial infarction complicated with CS and pulmonary edema were admitted to the Tianjin chest Hospital. Based on the use of a mechanical ventilator, patients were divided into the EPLV and Non-invasive ventilation (NIV) groups. Hemodynamic indexes and in-hospital mortality of patients between the two groups was analyzed.Results: The EPLV group consisted of 51 patients and the NIV group consisted of 38 patients. The difference in mortality rates was statistically significant between the EPLV and NIV groups (P=0.01). Central venous pressure, pulmonary artery pressure, and pulmonary capillary wedge pressure after emergency PCI in the EPLV group were lower compared to patients in the NIV group ((P<0.05). Man arterial pressure in patients in the EPLV group was higher compared to NIV patients (P<0.05). Logistic regression analysis showed that EPLV did not increase the risk of mortality (P=0.37, OR=2.16, 95% CI (0.31, 9.52)).Conclusion: EPLV resulted in lower mortality and improved hemodynamic function in patients with acute myocardial infarction complicated with CS and pulmonary edema undergoing emergency PCI.

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Mechanical Ventilation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Retrospective Observational Study

Cited by 15 publications

References 23 publications

Development and validation of nomogram to predict long-term prognosis of critically ill patients with acute myocardial infarction

Development and validation of nomogram to predict long-term prognosis of critically ill patients with acute myocardial infarction

Development and Validation of Nomogram to Predict Long-Term Prognosis of Critically Ill Patients with Acute Myocardial Infarction

Effect of Early Protective Lung Ventilation on Mortality and Hemodynamics in Patients With Acute Myocardial Infarction Complicated With Cardiogenic Shock and Pulmonary Edema Undergoing Emergency Interventional Therapy

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