“…On the contrary, titration of MV by airway conduction pressure, which is computed as PEEP airway pressure changes and PIP, equivalent to the relationship between Vt and respiratory system compliance, should better reflect the possibility of lung injury. 1,4,9 In the study by Amato et al, among ventilation variables, ΔP was more strongly associated with survival. An increment of 1 standard deviation (SD) in ΔP ($7 cm of water) was associated with increased mortality (relative risk, 1.41, 95% confidence interval [CI]: 1.31-1.51, p < 0.001), even in patients who received "protective" plateau pressures and Vt (relative risk, 1.36, 95% CI: 1.17-1.58, p < 0.001).…”