Mechanical ventilation of six dogs anaesthetised with isoflurane or sevoflurane delivered by a Komesaroff anaesthetic machine

Abstract

After intravenous induction, six beagles were connected to a Komesaroff machine provided with a single in-circuit vaporiser and ventilated mechanically at either nine or 14 breaths/minute while anaesthetised with either isoflurane or sevoflurane. The vaporiser was initially set at position 4/4 (fully open) and the anaesthetic concentrations were measured after one and five minutes; the vaporiser was then set at the lowest setting able to maintain anaesthesia. Cardiorespiratory variables were measured throughout the study. In most cases anaesthesia was maintained at setting 1/4 with isoflurane and at setting 1.5/4 or 2/4 with sevoflurane.

Comparing cardiac troponin levels using sevoflurane and isofluranein patients undergoing cardiac surgery: a systematic review and metaanalysis

“…13 Several animal studies have shown that volatiles anesthesia has a protective effect on myocardial infarction. [14][15][16][17] Human studies also indicate that these drugs have the potential to provide adequate anesthetic depth. Moreover, these drugs have protective effects on myocardial infarction.…”