Mechanically expanding transcatheter aortic valves: pros and cons of a unique device technology

Late coronary ischemıc syndromes assocıated wıth transcatheter aortıc valve ımplantatıon: A revıew of mechanıstıc and clınıcal aspects

“…Novel agents particularly targeting quantity, structure and functions of mast cells might potentially serve as promising preventive strategies in the setting of Kounis syndrome 38 associated with device implantation including TAVI.Since TAVI is generally considered as a last resort for high-risk surgical patients with severe AVS,1, 2, 3, 4, 5 every effort should be made to perform it in the most proper setting. On the other hand, deferrral of TAVI until patient-related risk factors for late coronary ischemic syndromes (if any) have been completely eliminated or, at least, minimized, seems to be a plausible option in clinically stable patients requiring TAVI.Lastly; specifically designed, and hence; unique TAVI devices (including mechanically expanding bioprostheses) have been tested so far in an effort to improve outcomes of TAVI in the clinical setting 39 . Within this context, further advancement in device technology (bioprostheses devoid of allergic, procoagulant characteristics, partially bioabsorbable frames, etc.)…”

“…Lastly; specifically designed, and hence; unique TAVI devices (including mechanically expanding bioprostheses) have been tested so far in an effort to improve outcomes of TAVI in the clinical setting 39 . Within this context, further advancement in device technology (bioprostheses devoid of allergic, procoagulant characteristics, partially bioabsorbable frames, etc.)…”

Aortic aneurysm in patients undergoing transcatheter aortic valve implantation: A prognostic determinant? or just an innocent bystander?

“…First, periprocedural vascular complications (aortic dissection, etc.) as well as stroke might not only be dependent on baseline aortic features (including aortic aneurysm, mural thrombus, calcification, and so forth) but also be strongly associated with the type of the TAVI delivery system (stiff or resilient), size of the catheter,4, 5 and operator experience. Within this context, certain valve types were previously suggested to be more likely to elicit acute vascular complications including aortic dissection and other life-threatening conditions including late coronary ischemic syndromes etc 4, 5…”