2001
DOI: 10.1006/bbrc.2001.6124
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Mechanically Induced ATP Release from Human Osteoblastic Cells

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Cited by 156 publications
(147 citation statements)
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“…connexin hemichannels, the P2X7 receptor) but the predominant mechanism appears to be vesicular exocytosis (see review [21]). The extent of cellular ATP release can also be influenced by external stimuli such as hypoxia [22,23], mechanical stress [24,25] and vitamin D [26]. Since ATP hydrolysis is a key source of extracellular pyrophosphate, factors which regulate ATP release may also indirectly affect pyrophosphate levels and thus the local rates of mineralisation.…”
Section: Generation and Regulation Of Extracellular Pyrophosphatementioning
confidence: 99%
See 1 more Smart Citation
“…connexin hemichannels, the P2X7 receptor) but the predominant mechanism appears to be vesicular exocytosis (see review [21]). The extent of cellular ATP release can also be influenced by external stimuli such as hypoxia [22,23], mechanical stress [24,25] and vitamin D [26]. Since ATP hydrolysis is a key source of extracellular pyrophosphate, factors which regulate ATP release may also indirectly affect pyrophosphate levels and thus the local rates of mineralisation.…”
Section: Generation and Regulation Of Extracellular Pyrophosphatementioning
confidence: 99%
“…Since osteocytes are embedded within bone they must be capable of preventing over-mineralisation of their lacunae (which could potentially compromise cell viability and function). ATP, which is released by all bone cells including osteocytes [22,25,[60][61][62][63][64][65], is an important source of pyrophosphate in bone [17,66]. Previous work has shown that endogenous ATP released by osteoblasts acts as an important local brake on mineralisation, an effect mediated by both purinergic signalling and the breakdown to produce pyrophosphate [38, 67,68].…”
Section: Pyrophosphate and Osteocytesmentioning
confidence: 99%
“…Controlled ATP release has been demonstrated from numerous excitatory and non-excitatory cells. In the bone microenvironment, osteoblasts (Buckley et al, 2003;Genetos et al, 2005;Orriss et al, 2009;Romanello et al, 2001;Rumney et al, 2012), osteoclasts and MLO-Y4 osteocyte-like cells (Genetos et al, 2007;Kringelbach et al, 2014) have all been shown to constitutively release ATP.…”
Section: Extracellular Nucleotides and The Regulation Of Bone Mineralmentioning
confidence: 99%
“…Controlled ATP release from osteoblast-like cells was first described by Romanello et al in 2001(Romanello et al, 2001. Since then several studies have indicated that the primary method of ATP release from osteoblasts is by vesicular exocytosis (Genetos et al, 2005;Orriss et al, 2009;Romanello et al, 2005).…”
Section: Atp Release From Osteoblastsmentioning
confidence: 99%
“…cells to mechanical stimulation, a phenomenon that also has been scientifically documented [3][4][5][6][7]. Renal epithelial cells, especially Madin-Darby canine kidney (MDCK) cells, a well-differentiated cell line derived from distal tubule/collecting duct, was found to respond to nucleotide signaling via P2 receptor activation already 30 years ago [8].…”
mentioning
confidence: 99%