Mechanics of axon growth and damage: A systematic review of computational models

Axonal tension contributes to consistent fold placement

“…First, we assume the time-independent elastic behavior in axons. This fails to capture the viscoelastic 70,71 and growing 15 behavior of axons. While viscoelasticity is likely not so relevant on the timescales of growth (days and weeks), growth could play a very significant role in the mechanical forces exerted on the cortex by axons.…”

Dynamics of the axon plasma membrane skeleton

“…21 However, it is important to clarify the mechanical behavior of the APMS separately from the endoplasmic cytoskeleton. While there exists a significant amount of work on modeling of the behavior of the entire axon during extension [22][23][24][25][26] and in particular of the microtubules network, 11,27 there is a very limited work on modelling extension of the APMS. In this paper, we focus on just that, the mechanical behavior of the APMS during extension and during relaxation.…”

Effects of nonlinear membrane capacitance in the Hodgkin-Huxley model of action potential on the spike train patterns of a single neuron

“…The charges on both sides of the membrane generate an electrostatic force on the lipid layer leading to a change in the dimension of the cell membrane [21]. The deformation of the axon membrane occurs due to damage of axons during brain injury [22,23]. Due to their fluid and elastic nature, cell membranes can change their dimensions under the influence of externally applied and internally generated forces.…”