Mechanics of the Cochlea

Olson, Elizabeth S.

doi:10.1016/b978-0-12-809324-5.24124-2

The Senses: A Comprehensive Reference 2020

DOI: 10.1016/b978-0-12-809324-5.24124-2

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Mechanics of the Cochlea

Elizabeth S. Olson¹

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2024

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Effects of Castanopsis echinocarpa on Sensorineural Hearing Loss via Neuronal Gene Regulation

Rodriguez,

Nam,

Shin

et al. 2024

Nutrients

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Sensorineural hearing loss (SNHL), characterized by damage to the inner ear or auditory nerve, is a prevalent auditory disorder. This study explores the potential of Castanopsis echinocarpa (CAE) as a therapeutic agent for SNHL. In vivo experiments were conducted using zebrafish and mouse models. Zebrafish with neomycin-induced ototoxicity were treated with CAE, resulting in otic hair cell protection with an EC50 of 0.49 µg/mL and a therapeutic index of 1020. CAE treatment improved auditory function and protected cochlear sensory cells in a mouse model after noise-induced hearing loss (NIHL). RNA sequencing of NIHL mouse cochleae revealed that CAE up-regulates genes involved in neurotransmitter synthesis, secretion, transport, and neuronal survival. Real-time qPCR validation showed that NIHL decreased the mRNA expression of genes related to neuronal function, such as Gabra1, Gad1, Slc32a1, CaMK2b, CaMKIV, and Slc17a7, while the CAE treatment significantly elevated these levels. In conclusion, our findings provide strong evidence that CAE protects against hearing loss by promoting sensory cell protection and enhancing the expression of genes critical for neuronal function and survival.

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Effects of Castanopsis echinocarpa on Sensorineural Hearing Loss via Neuronal Gene Regulation

Rodriguez,

Nam,

Shin

et al. 2024

Nutrients

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show abstract

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Mechanics of the Cochlea

Cited by 1 publication

References 203 publications

Effects of Castanopsis echinocarpa on Sensorineural Hearing Loss via Neuronal Gene Regulation

Effects of Castanopsis echinocarpa on Sensorineural Hearing Loss via Neuronal Gene Regulation

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