2024
DOI: 10.1002/adfm.202315382
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Mechanics‐Resilient HA/SIS‐Based Composite Scaffolds with ROS‐Scavenging and Bacteria‐Resistant Capacity to Address Infected Bone Regeneration

Zelong Song,
Haichao Yu,
Linhao Hou
et al.

Abstract: To address and regenerate infected bone defects complicated by issues such as inflammation and bone resorption, and to promote bone regeneration, this study focuses on the development of a composite scaffold with reactive oxygen species (ROS)‐scavenging and bacteria‐resistant properties. The composite scaffold integrates a self‐assembled small intestinal submucosa (SIS) hydrogel with pre‐adsorbed hydroxyapatite (HA) particles and tannic acid (TA), demonstrating distinctive mechanical resilience and porous stru… Show more

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Cited by 8 publications
(1 citation statement)
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“…In addition, inflammation always produces an overabundance of reactive oxygen species (ROS), which directly degrade nucleic acids, proteins, and lipids, causing irreversible damage to the organism [ 30 , 34 ]. TA-based coatings are promising for the treatment of inflammation, as TA is a natural anti-oxidant [ 35 ]. The free radical scavenging capacities of Ti–OH-MC against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2ʹ-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) were evaluated in this study.…”
Section: Resultsmentioning
confidence: 99%
“…In addition, inflammation always produces an overabundance of reactive oxygen species (ROS), which directly degrade nucleic acids, proteins, and lipids, causing irreversible damage to the organism [ 30 , 34 ]. TA-based coatings are promising for the treatment of inflammation, as TA is a natural anti-oxidant [ 35 ]. The free radical scavenging capacities of Ti–OH-MC against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2ʹ-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) were evaluated in this study.…”
Section: Resultsmentioning
confidence: 99%