Mechanism and Clinical Significance of the Prothrombotic State in Patients With Essential Hypertension

Yang, Ping; Liu, Yafen; Li, Yang; Wang, Qun; Zeng, Hong

doi:10.1002/clc.20719

Cited by 27 publications

(12 citation statements)

References 20 publications

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“…The concomitant diseases such as hypertension and infection may be the causes of hypercoagulable. (22,(25)(26)(27) Furthermore the trauma of subsequent revision surgery, intraoperative blood loss and transfusions may lead to a hypercoagulable state. The main risk factors of thrombosis following trauma of surgery include: physical disruption of the endothelium in trauma or surgery, blood ow is relatively static, stasis and local accumulation of tissue factor, the expression of tissue factors caused by stimulation of in ammatory mediators.…”

Section: Discussionmentioning

confidence: 99%

Changes in coagulation status as measured by thromboelastography in patients undergoing revision total hip arthroplasty

Yang

Zhu

Qin

et al. 2020

Preprint

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Background: Venous thromboembolism events (VTEs) continue to be of the most widespread severe complication following total hip arthroplasty (THA) and total knee arthroplasty (TKA). However, there are no optimal accurate monitoring methods to assess the changes in coagulability after anticoagulation and anti-fibrinolysis during the perioperative period. Therefore, the objective of this study is to determine changes in coagulability as measured by thromboelastography (TEG) following revision total hip arthroplasty when the patients received rivaroxaban and tranexamic acid in perioperative period during enhanced recovery after surgery (ERAS). Methods: We retrospectively reviewed 70 revision TKA patients (mean age 63.69±10.17 years). Perioperative management of each patient was conducted in accordance with ERAS. The patients received tranexamic (TXA) to control perioperative bleeding. TEG was performed pre-operatively and on post-operative days (POD) 1, 3, 5 and 7. TEG-hypercoagulability was classified into three types: enzymatic hypercoagulability, platelet hypercoagulability and mixed hypercoagulability. Screening for coagulation-related complications at three months of follow-up. Results: The mean duration of surgery was 2.91±0.99 h. the mean intraoperative blood loss of patients was 486.43±346.92 ml. And 55.71% (39) patients received transfusion, the mean blood transfusion volume was 482.86 ± 458.79 ml. There only were 4 (5.71%) patients who suffered postoperative coagulation-related complications. 1 patient with hypercoagulable on preoperative developed intramuscular venous thrombosis at 1 month postoperatively. 1 patient with hypercoagulability at POD5 and POD7 suffered melena at POD5. 2 patients with hypocoagulability developed ecchymosis at POD3. The proportion of postoperative hypercoagulable state is gradually increasing. The distribution of different hypercoagulable states on the postoperative day (POD) 5 and 7 were significantly different from that pre-operation (Pre) and POD1 (POD5 vs Pre: p=0.011; POD5 vs POD1: p=0.001; POD7 vs Pre: p=0.001; POD7 vs POD5: p<0.001). We found 32.86%(23) revision THA with hypercoagulable state on POD7.For 78.26%(18) of these patients there was mixed hypercoagulability. Conclusions: In ERAS, thromboelastography was an effective way to identify hypercoagulable state in patients undergoing revision hip arthroplasty, and mixed hypercoagulability is the predominant hypercoagulable state following revision hip arthroplasty. In addition, it is very important to develop an individualized coagulation management program.

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Section: Discussionmentioning

confidence: 99%

Changes in coagulation status as measured by thromboelastography in patients undergoing revision total hip arthroplasty

Yang

Zhu

Qin

et al. 2020

Preprint

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“…smoking, body mass index, diet, physical activity, blood pressure, glucose, and cholesterol levels. [31] This set of recommendations, like those of the United States Preventive Services Task Force 2013, advises intensive interventions for weight management and additionally offers much more detail on recommended diet and exercise.…”

Section: Discussionmentioning

confidence: 99%

Association of physical activity, nature of job, and exercise with the prevalence of essential hypertension in the Tharparkar desert

Umedani

2015

Int J Med Sci Public Health

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Results: After getting approval from the ethics review committee, the mean age and prevalence of EHTN among the studied 563 participants from Tharparkar desert were assessed and found to be 37 (±16.4 years, range 10-82 years) and 81 (14.4%), respectively. Participants leading a sedentary lifestyle showed higher prevalence of EHTN (19.2%) than those leading an active lifestyle (1.9%). Participants having job with mild physical activity had higher prevalence of EHTN (19.4%) than those having jobs with active lifestyle (2.9%); p-values were <0.001 in both cases. The analysis of data for participants not doing exercise and prevalence of EHTN did not show statistically significant p-value (i.e., 0.57). Conclusion: It is concluded that in the Tharparkar desert, mild physical activity and jobs with sedentary lifestyle were significantly associated with the prevalence of EHTN. The comparison of participants doing versus not-doing exercise showed nonsignificant results because of the small sample size of those responding positive for exercise.

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“…Similarly, P-selectin, a marker of platelet activation is increased in hypertensive individuals and is reduced by antihypertensive treatment [64]. Additionally, increases in PAI-1 and P-selectin are increased in disease and correlate with endothelial dysfunction, suggesting a potential role in the pathogenesis of hypertension [65]. Finally, von Willebrand factor, a glycoprotein which is secreted by endothelial cells and plays a role in blood coagulation, is increased in hypertension and correlates with measures of endothelial function [64,[66][67][68].…”

Section: Markers Of Coagulationmentioning

confidence: 96%

Biomarkers in Hypertension

Touyz

Burger

2012

Special Issues in Hypertension

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Mechanism and Clinical Significance of the Prothrombotic State in Patients With Essential Hypertension

Abstract: The hypercoagulative state exists in patients with hypertension and this state was more obvious with the elevation of blood pressure and coincided with an impairment in the degree of endothelium-dependent vasodilation.

Cited by 27 publications

References 20 publications

Changes in coagulation status as measured by thromboelastography in patients undergoing revision total hip arthroplasty

Changes in coagulation status as measured by thromboelastography in patients undergoing revision total hip arthroplasty

Association of physical activity, nature of job, and exercise with the prevalence of essential hypertension in the Tharparkar desert

Biomarkers in Hypertension

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