Mechanism and function of miR-140 in human cancers: A review and in silico study

Taheri, Forough; Ebrahimi, Seyed Omar; Heidari, Razieh; pour, Somaye Nezamabadi; Reiisi, Somayeh

doi:10.1016/j.prp.2022.154265

Cited by 3 publications

(3 citation statements)

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“…In colorectal cancer (CRC), BCL2 is recognized as a direct target of miR140-3p (Liu et al 2021 ). It has been shown that miR-140-3p regulates the PI3K/AKT, JAK/STAT, mTOR, TGFβ/Smad, and Wnt pathways in tumors (Taheri et al 2023 ), while HOXA9 influences the expression levels of PI3K/AKT, JAK/STAT, mTOR, NF-kB, HIF1a, and the Wnt pathway (Tang et al 2022 ). Therefore, miR-140-3p and HOXA9 may engage in crosstalk at various cellular levels.…”

Section: Discussionmentioning

confidence: 99%

“…These aberrantly expressed miRNAs hold promise as novel targets for CRC therapies (Ciesla et al 2011 ). Notably, miR-140-3p has been observed to display altered expression patterns in various cancer types, including lung cancer, breast cancer, spinal cord chordoma, and hepatocellular carcinoma and so on (Taheri et al 2023 ). miR-140-3p functions as a tumor suppressor, playing a crucial role in various cellular processes and influencing signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

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Exploring the expression and clinical significance of the miR-140-3p-HOXA9 axis in colorectal cancer

Cui,

Bai,

Bai

et al. 2024

J Cancer Res Clin Oncol

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Purpose This study aims to investigate the expression patterns and clinical significance of miR-140-3p and homeobox A9 (HOXA9) in colorectal cancer (CRC) selected by bioinformatic study, while elucidating their potential interplay. Methods The microRNA expression profiles of paired colorectal cancer and matched normal tissues were retrieved from the Gene Expression Omnibus Database. Differentially expressed microRNAs and microRNA candidates were filtered and subjected to further analysis. Clinicopathological data, along with paraffin-embedded samples of colorectal tumor tissues were collected to facilitate comprehensive analysis. Expression levels of miR-140-3p and HOXA9 were quantified using qRT-PCR and immunohistochemistry. Survival rates were determined using the Kaplan–Meier method, and the COX regression model was utilized to identify independent prognostic factors that impact the overall prognosis. Results MiR-140-3p was significantly downregulated in colorectal tumors compared to normal tissue, and HOXA9 was identified as a previously unreported potential downstream target. HOXA9 expression was elevated in tumors compared to normal tissues. Reduced miR-140-3p expression was associated with lymph node metastasis, while high HOXA9 expression correlated with both lymph node metastasis and lympho-vascular invasion. Patients with low miR-140-3p and high HOXA9 expression had a poorer prognosis. HOXA9 was identified as an independent risk factor for CRC patient survival. Conclusion The miR-140-3p-HOXA9 signaling disruption is closely linked to lymph node metastasis and unfavorable prognosis in CRC. This axis shows promise as a clinical biomarker for predicting the CRC patient survival and a potential therapeutic target.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the expression and clinical significance of the miR-140-3p-HOXA9 axis in colorectal cancer

Cui,

Bai,

Bai

et al. 2024

J Cancer Res Clin Oncol

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“…miR-140 is one of the miRNAs that play a variety of roles in human diseases [ 142 ]. miR-140-5p has been shown to control the inflammatory signaling cascade, such as the toll-like receptor 4 (TLR4)/NF-κB signaling pathway [ 143 ].…”

Section: Mirna As a Biomarker Of Dicmentioning

confidence: 99%

MicroRNA in the Diagnosis and Treatment of Doxorubicin-Induced Cardiotoxicity

Kuang

Tan

et al. 2023

Biomolecules

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Doxorubicin (DOX), a broad-spectrum chemotherapy drug, is widely applied to the treatment of cancer; however, DOX-induced cardiotoxicity (DIC) limits its clinical therapeutic utility. However, it is difficult to monitor and detect DIC at an early stage using conventional detection methods. Thus, sensitive, accurate, and specific methods of diagnosis and treatment are important in clinical practice. MicroRNAs (miRNAs) belong to non-coding RNAs (ncRNAs) and are stable and easy to detect. Moreover, miRNAs are expected to become biomarkers and therapeutic targets for DIC; thus, there are currently many studies focusing on the role of miRNAs in DIC. In this review, we list the prominent studies on the diagnosis and treatment of miRNAs in DIC, explore the feasibility and difficulties of using miRNAs as diagnostic biomarkers and therapeutic targets, and provide recommendations for future research.

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Engineered mesoporous silica nanoparticles, new insight nanoplatforms into effective cancer gene therapy

Heidari,

Assadollahi,

Khosravian

et al. 2023

International Journal of Biological Macromolecules

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Mechanism and function of miR-140 in human cancers: A review and in silico study

Cited by 3 publications

References 165 publications

Exploring the expression and clinical significance of the miR-140-3p-HOXA9 axis in colorectal cancer

Exploring the expression and clinical significance of the miR-140-3p-HOXA9 axis in colorectal cancer

MicroRNA in the Diagnosis and Treatment of Doxorubicin-Induced Cardiotoxicity

Engineered mesoporous silica nanoparticles, new insight nanoplatforms into effective cancer gene therapy

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