Mechanism and Management of Cancer Chemotherapy-Induced Atherosclerosis

Abstract

The advent of new chemotherapeutic and immunotherapeutic treatments has markedly improved outcomes in patients with cancer. However, increasing numbers of elderly patients with cancer and prolonged periods of treatment have made the management of cardiovascular complications and treatment-induced cardiotoxicity an important concern, and onco-cardiology has received increasing attention. The number of patients with cardiotoxicity, particularly atherosclerotic lesions, and the usage of angiogenesis inhibitors have increased, making the involvement of onco-cardiologists essential for effective disease management. A paradigm shift in immunotherapy was caused by the development of immune checkpoint inhibitors. Because vascular endothelial growth factors (VEGF) in the cancer microenvironment and cancer immune function are interrelated angiogenesis inhibitors will most likely play an increasingly important role in combined immunotherapy. To ensure the optimal long-term diagnosis and long-term treatment of cancer and the effective management of treatment-related atherosclerotic diseases, the long-term continuous participation of onco-cardiologists is essential.

Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma

“…The interaction between estrogen biosynthesis and lipid metabolism may be one of the high-risk factors for LUAD, and is consistent with the observation that LUAD incidence is rising in women, and that the incidence rate among women was higher than that among men [2]. Lipid and cancer-related genes have been shown to be enriched in atherosclerosis and cancer [45]. For long-term survival of LUAD patients, their health management should be managed by oncologists and cardiologists.…”

<p>Clinical Significance of Factor XIII Activity and Monocyte-Derived Microparticles in Cancer Patients</p>

“…32,33 It is necessary to consider the thrombosis associated with the treatment for cancer separately from the original risk of cancer itself. 9 In addition, even if the cancer treatment is successful, we have to consider the other factors or side effects of anticancer drugs. Therefore, predicting CAT is an important proposition for cancer in clinical practice.…”

“…8 Vascular disorders, associated with chemotherapy or enhancement of the coagulation system, are important as factors of VTE. 9 Factor XIII (FXIII) is present in the blood as a heterotetramer that is formed by FXIII-A and FXIII-B subunit polymers. 10 FXIII-A is present mainly in platelets, megakaryocytes, monocytes, and macrophages.…”

Lipid metabolic gene-wide profile and survival signature of lung adenocarcinoma&nbsp;

“…The interaction between estrogen biosynthesis and lipid metabolic may be one of the high-risk factors for LUAD, which is consistent with the observation that LUAD incidence is rising in women, and the incidence rate among female was higher than that among men [38]; Lipid and cancer-related genes were enriched in atherosclerosis and cancer. For long-term survival LUAD patients, their health management should be involved by oncologists and cardiologists [39].…”